Who I am: I have been at Imperial College since 2004, as head of the Neural Coding Laboratory in the Department of Bioengineering. My first degrees were in Electrical & Computer Systems Engineering, and Physics, from Monash University in Australia. I obtained my D.Phil. in the area of computational neuroscience, under Prof Edmund Rolls at Oxford. I then undertook postdoctoral research in experimental neuroscience at New York University (with Tony Movshon) and University College London (with Michael Häusser).
Research Interests: My main interest is in "reverse engineering" the information processing architecture of the brain. Specifically, I investigate the basic principles of information processing in cortical circuits. I take an "engineering approach" which involves both doing experiments (in mice), together with theoretical work to help us understand the data from these experiments. On the experimental side, we use two-photon microscopy, optogenetics and electrophysiology to measure (and perturb) patterns of neuronal activity in vivo. On the theoretical side, we develop new algorithms for analysing the resulting data (particularly making use of Information Theory), and develop models to help us interpret it.
I believe that understanding the functional principles of cortical circuits is crucial to understanding, and treating, the effects of brain disorders. I am particularly interested in changes in cortical circuit properties during dementias such as Alzheimer's Disease, and have recently launched a project in my laboratory focussed on this.
You can read more at my Lab Web Page.
Simon’s research publications can be found at the tab above, or on Google Scholar
et al., 2021, Integrating new memories into the hippocampal network activity space, Nature Neuroscience, Vol:24, ISSN:1097-6256, Pages:326-330
et al., 2021, Place cells in head-fixed mice navigating a floating real-world environment, Frontiers in Cellular Neuroscience, Vol:15, ISSN:1662-5102
et al., 2021, Dual midbrain and forebrain origins of thalamic inhibitory interneurons, Elife, Vol:10, ISSN:2050-084X, Pages:1-29
et al., 2017, Robotic automation of in vivo two photon targeted whole-cell patch clamp electrophysiology, Neuron, Vol:95, ISSN:0896-6273, Pages:1048-1055.e3
et al., 2016, Visual receptive field properties of neurons in the mouse lateral geniculate nucleus, PLOS One, Vol:11, ISSN:1932-6203