Imperial College London
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ProfessorSimonSchultz

Faculty of Engineering, Department of Bioengineering

Professor of Neurotechnology
 
 
 
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Contact

 

s.schultz Website

 
 
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Location

 

4.11Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tolkiehn:2019:10.1101/708644,
author = {Tolkiehn, M and Schultz, SR},
doi = {10.1101/708644},
title = {Temporo-nasally biased moving grating selectivity in mouse primary visual cortex},
url = {http://dx.doi.org/10.1101/708644},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Orientation tuning in mouse primary visual cortex (V1) has long been reported to have a random or “salt-and-pepper” organisation, lacking the structure found in cats and primates. Laminar in-vivo multi-electrode array recordings here reveal previously elusive structure in the representation of visual patterns in the mouse visual cortex, with temporo-nasally drifting gratings eliciting consistently highest neuronal responses across cortical layers and columns, whilst upward moving gratings reliably evoked the lowest activities. We suggest this bias in direction selectivity to be behaviourally relevant as objects moving into the visual field from the side or behind may pose a predatory threat to the mouse whereas upward moving objects do not. We found furthermore that direction preference and selectivity was affected by stimulus spatial frequency, and that spatial and directional tuning curves showed high signal correlations decreasing with distance between recording sites. In addition, we show that despite this bias in direction selectivity, it is possible to decode stimulus identity and that spatiotemporal features achieve higher accuracy in the decoding task whereas spike count or population counts are sufficient to decode spatial frequencies implying different encoding strategies.</jats:p><jats:sec><jats:title>Significance statement</jats:title><jats:p>We show that temporo-nasally drifting gratings (i.e. opposite the normal visual flow during forward movement) reliably elicit the highest neural activity in mouse primary visual cortex, whereas upward moving gratings reliably evoke the lowest responses. This encoding may be highly behaviourally relevant, as objects approaching from the periphery may pose a threat (e.g. predators), whereas upward moving objects do not. This is a result at odds with the belief that mouse primary visual cortex is randomly organised. Fur
AU  - Tolkiehn,M
AU  - Schultz,SR
DO  - 10.1101/708644
PY  - 2019///
TI  - Temporo-nasally biased moving grating selectivity in mouse primary visual cortex
UR  - http://dx.doi.org/10.1101/708644
ER  -
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