Publications
104 results found
Shaunak S, Brocchini S, 2007, Entrepreneurial experiences, NATURE REVIEWS DRUG DISCOVERY, Vol: 6, Pages: 499-499, ISSN: 1474-1776
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- Citations: 1
Godwin A, Choi J-W, Pedone E, et al., 2007, Molecular dynamics simulations of proteins with chemically modified disulfide bonds, 10th Electronic Computational Chemistry Conference, Publisher: SPRINGER, Pages: 259-265, ISSN: 1432-881X
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- Citations: 10
Zloh M, Shaunak S, Balan S, et al., 2007, Identification and insertion of 3-carbon bridges in protein disulfide bonds: a computational approach, NATURE PROTOCOLS, Vol: 2, Pages: 1070-1083, ISSN: 1754-2189
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- Citations: 22
Balan S, Choi J-W, Godwin A, et al., 2006, Site-specific PEGylation of protein disulfide bonds using a three-carbon bridge, BIOCONJUGATE CHEMISTRY, Vol: 18, Pages: 61-76, ISSN: 1043-1802
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- Citations: 135
Steel A, Clark S, Teo I, et al., 2006, No change to HIV-1 latency with valproate therapy, AIDS, Vol: 20, Pages: 1681-1682, ISSN: 0269-9370
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- Citations: 25
Shaunak S, Godwin A, Choi J-W, et al., 2006, Site-specific PEGylation of native disulfide bonds in therapeutic proteins, NATURE CHEMICAL BIOLOGY, Vol: 2, Pages: 312-313, ISSN: 1552-4450
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- Citations: 220
Brocchini S, Balan S, Godwin A, et al., 2006, PEGylation of native disulfide bonds in proteins., Nature Protocols, Vol: 1, Pages: 2241-2252
Shaunak S, Brocchini S, 2006, Dendrimer-based drugs as macromolecular medicines., Biotechnol Genet Eng Rev, Vol: 23, Pages: 309-315, ISSN: 0264-8725
Summers SA, Dorling A, Boyle JJ, et al., 2005, Cure of disseminated cryptococcal infection in a renal allograft recipient after addition of γ-interferon to anti-fungal therapy, AMERICAN JOURNAL OF TRANSPLANTATION, Vol: 5, Pages: 2067-2069, ISSN: 1600-6135
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- Citations: 21
Teo I, Choi JW, Buttigieg K, et al., 2005, Pitfalls of culturing C8166 cells in serum-free media, AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol: 21, Pages: 246-248, ISSN: 0889-2229
Teo I, Choi J-W, Buttigieg K, et al., 2005, Short communication: pitfalls of culturing C8166 cells in serum-free media., AIDS Res Hum Retroviruses, Vol: 21, Pages: 246-248, ISSN: 0889-2229
Long-term culture of C8166 cells in serum-free media can result in changes in their level of expression of immunologically important cell surface makers and a loss of infectivity by HIV-1. We have now demonstrated that these phenotypic changes are due to an outgrowth of a very small number of contaminating cells of mouse origin. Our observations emphasize the importance of carefully recharacterizing any cells that have been adapted to grow in a serum-free culture media.
Shaunak S, Thomas S, Gianasi E, et al., 2004, Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation, NATURE BIOTECHNOLOGY, Vol: 22, Pages: 977-984, ISSN: 1087-0156
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- Citations: 245
Jones E, Mireskandari K, Mead A, et al., 2004, The effect of novel immuno-modulatory and anti-angiogenic glycodendrimers in a rabbit model of glaucoma surgery, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Pages: U392-U392, ISSN: 0146-0404
Shaunak S, 2004, Dendrimer drugs prevent scar tissue formation, Discovery Medicine, Editors: Rose, Publisher: Peter H. Rheinstein, Pages: 464-469
Shaunak S, Teo I, 2003, Monitoring HIV disease with new and clinically useful surrogate markers, CURRENT OPINION IN INFECTIOUS DISEASES, Vol: 16, Pages: 581-586, ISSN: 0951-7375
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- Citations: 3
Shaunak S, Teo I, Choi JW, et al., 2003, HIV DNA two long terminal repeat circles: observations and interpretations, AIDS, Vol: 17, Pages: 2273-2274, ISSN: 0269-9370
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- Citations: 2
Shaunak S, Thornton M, Teo I, et al., 2003, Optimisation of the degree of sulfation of a polymer based construct to block the entry of HIV-1 into cells, JOURNAL OF DRUG TARGETING, Vol: 11, Pages: 443-448, ISSN: 1061-186X
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- Citations: 12
Stebbing J, Gazzard B, Kim L, et al., 2003, The heat-shock protein receptor CD91 is up-regulated in monocytes of HIV-1-infected "true" long-term nonprogressors, BLOOD, Vol: 101, Pages: 4000-4004, ISSN: 0006-4971
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- Citations: 41
Morlese J, Teo IA, Choi JW, et al., 2003, Identification of two mutually exclusive groups after long-term monitoring of HIV DNA 2-LTR circle copy number in patients on HAART, AIDS, Vol: 17, Pages: 679-683, ISSN: 0269-9370
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- Citations: 22
Shaunak S, 2003, HIV and its manipulation of chemokine receptors, Postgraduate Medical Sciences Series. Infection and Immunity, Editors: Friedland, Lightstone, Publisher: Martin Dunitz Publishers, Pages: 177-190
Teo IA, Morlese J, Choi JW, et al., 2002, Reliable and reproducible LightCycler qPCR for HIV-1 DNA 2-LTR circles, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 270, Pages: 109-118, ISSN: 0022-1759
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- Citations: 14
Teo IA, Choi JW, Morlese J, et al., 2002, LightCycler qPCR optimisation for low copy number target DNA, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 270, Pages: 119-133, ISSN: 0022-1759
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- Citations: 48
Shaunak S, Davies DS, 2002, Surrogacy in antiviral drug development, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 54, Pages: 75-80, ISSN: 0306-5251
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- Citations: 3
Vyakarnam A, Eyeson J, Teo I, et al., 2001, Evidence for a post-entry barrier to R5 HIV-1 infection of CD4 memory T cells, AIDS, Vol: 15, Pages: 1613-1626, ISSN: 0269-9370
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- Citations: 12
Shaunak S, Veryard C, Javan C, 2001, Severe <i>Pneumocystis carinii</i> pneumonia increases the infectious titre of HIV-1 in blood and can promote the expansion of viral chemokine co-receptor tropism, JOURNAL OF INFECTION, Vol: 43, Pages: 3-6, ISSN: 0163-4453
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- Citations: 13
Kelleher AD, Long C, Holmes EC, et al., 2001, Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses, Journal of Experimental Medicine, Vol: 193, Pages: 375-385, ISSN: 0022-1007
The immune response to HIV-1 in patients who carry human histocompatibility leukocyte antigen (HLA)-B27 is characterized by an immunodominant response to an epitope in p24 gag (amino acids 263–272, KRWIILGLNK). Substitution of lysine (K) or glycine (G) for arginine (R) at HIV-1 gag residue 264 (R264K and R264G) results in epitopes that bind to HLA-B27 poorly. We have detected a R264K mutation in four patients carrying HLA-B27. In three of these patients the mutation occurred late, coinciding with disease progression. In another it occurred within 1 yr of infection and was associated with a virus of syncytium-inducing phenotype. In each case, R264K was tightly associated with a leucine to methionine change at residue 268. After the loss of the cytotoxic T lymphocyte (CTL) response to this epitope and in the presence of high viral load, reversion to wild-type sequence was observed. In a fifth patient, a R264G mutation was detected when HIV-1 disease progressed. Its occurrence was associated with a glutamic acid to aspartic acid mutation at residue 260. Phylogenetic analyses indicated that these substitutions emerged under natural selection rather than by genetic drift or linkage. Outgrowth of CTL escape viruses required high viral loads and additional, possibly compensatory, mutations in the gag protein.
Veryard C, Javan C, Shaunak S, 2000, Repeated and spontaneous switching of the chemokine co-receptors used by HIV-1 is rare <i>in vivo</i>, AIDS, Vol: 14, Pages: 2942-2943, ISSN: 0269-9370
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- Citations: 3
Leen C, Shaunak S, Steinhart C, 2000, Tolerability of a novel approach to salvage therapy for AIDS, AIDS, Vol: 14, Pages: S39-S40, ISSN: 0269-9370
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- Citations: 1
Wilson JDK, Ogg GS, Allen RL, et al., 2000, Direct visualization of HIV-1-specific cytotoxic T lymphocytes during primary infection, AIDS, Vol: 14, Pages: 225-233, ISSN: 0269-9370
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- Citations: 130
Pickering MC, Barkham T, Mason JC, et al., 2000, Bilateral gluteal abscesses as a unique manifestation of <i>Fusobacterium</i> septicaemia, RHEUMATOLOGY, Vol: 39, Pages: 224-225, ISSN: 1462-0324
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- Citations: 8
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