Imperial College London
Alternate

ProfessorSunilShaunak

Faculty of Medicine, Department of Infectious Disease

Emeritus Professor in Infectious Diseases
 
 
 
//

Contact

 

s.shaunak Website

 
 
//

Location

 

8.N15Hammersmith HospitalHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Corware:2010:10.1016/j.trstmh.2010.08.010,
author = {Corware, KD and Rogers, M and Teo, I and Muller, I and Shaunak, S},
doi = {10.1016/j.trstmh.2010.08.010},
journal = {Transactions of the Royal Society of Tropical Medicine and Hygiene},
pages = {749--750},
title = {An amphotericin B-based drug for treating experimental Leishmania major infection},
url = {http://dx.doi.org/10.1016/j.trstmh.2010.08.010},
volume = {104},
year = {2010}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There is an urgent need for a non-toxic and low-cost treatment for cutaneous leishmaniasis. We synthesised and tested in vivo an amphotericin B-poly(methacrylic acid) drug (AmB-PMA) that had previously shown in-vitro activity against Leishmania major and L. donovani parasites. Efficacy was determined using L. major footpad infection in 30 non-healing BALB/c mice. Three subcutaneous injections of AmB-PMA at days 7, 14 and 21 post-infection resulted in a reduction of ∼80% in lesion size by day 35 post-infection in 18 treated mice compared with six untreated controls, and complete healing of lesions by day 50 with no lesion relapse seen at day 80 post-infection in six treated mice. Healing was associated with decreased IL-10 (P=0.002) and increased IFN-γ (P=0.005) in the footpad.
AU  - Corware,KD
AU  - Rogers,M
AU  - Teo,I
AU  - Muller,I
AU  - Shaunak,S
DO  - 10.1016/j.trstmh.2010.08.010
EP  - 750
PY  - 2010///
SP  - 749
TI  - An amphotericin B-based drug for treating experimental Leishmania major infection
T2  - Transactions of the Royal Society of Tropical Medicine and Hygiene
UR  - http://dx.doi.org/10.1016/j.trstmh.2010.08.010
VL  - 104
ER  -
Download