Imperial College London
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DrSanoojSoni

Faculty of Medicine, Department of Surgery & Cancer

Clinical Senior Lecturer in Critical and Perioperative Care
 
 
 
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Contact

 

s.soni

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Soni:2021:10.1152/ajplung.00099.2020,
author = {Soni, S and Garner, J and O'Dea, K and Kohn, M and Finney, L and Tirlapur, N and Srikanthan, K and aboelhassan, A and Singh, S and Wilson, M and Wedzicha, J and Kemp, S and Usmani, O and Shah, P and Takata, M},
doi = {10.1152/ajplung.00099.2020},
journal = {American Journal of Physiology: Lung Cellular and Molecular Physiology},
pages = {L73--L83},
title = {Intra-alveolar neutrophil-derived microvesicles are associated with disease severity in COPD},
url = {http://dx.doi.org/10.1152/ajplung.00099.2020},
volume = {320},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Despite advances in the pathophysiology of Chronic Obstructive Pulmonary Disease (COPD), there is a distinct lack of biochemical markers to aid clinical management. Microvesicles (MVs) have been implicated in the pathophysiology of inflammatory diseases including COPD but their association to COPD disease severity remains unknown. We analysed different MV populations in plasma and bronchoalveolar lavage fluid (BALF) taken from sixty-two patients with mild to very severe COPD (51% male; mean age: 65.9 years). These patients underwent comprehensive clinical evaluation (symptom scores, lung function, exercise testing) and the capacity of MVs to be clinical markers of disease severity was assessed. We successfully identified various MV subtype populations within BALF (leukocyte, PMN (polymorphonuclear leukocyte i.e. neutrophil), monocyte, epithelial and platelet MVs) and plasma (leukocyte, PMN, monocyte and endothelial MVs), and compared each MV population to disease severity. BALF neutrophil MVs were the only population to significantly correlate with the clinical evaluation scores including FEV1, mMRC dyspnoea score, 6-minute walk test, hyperinflation and gas transfer. BALF neutrophil MVs, but not neutrophil cell numbers, also strongly correlated with BODE index. We have undertaken, for the first time, a comprehensive evaluation of MV profiles within BALF/plasma of COPD patients. We demonstrate that BALF levels of neutrophil-derived MVs are unique in correlating with a number of key functional and clinically-relevant disease severity indices. Our results show the potential of BALF neutrophil MVs for a COPD biomarker that tightly links a key pathophysiological mechanism of COPD (intra-alveolar neutrophil activation) with clinical severity/outcome.
AU  - Soni,S
AU  - Garner,J
AU  - O'Dea,K
AU  - Kohn,M
AU  - Finney,L
AU  - Tirlapur,N
AU  - Srikanthan,K
AU  - aboelhassan,A
AU  - Singh,S
AU  - Wilson,M
AU  - Wedzicha,J
AU  - Kemp,S
AU  - Usmani,O
AU  - Shah,P
AU  - Takata,M
DO  - 10.1152/ajplung.00099.2020
EP  - 83
PY  - 2021///
SN  - 1040-0605
SP  - 73
TI  - Intra-alveolar neutrophil-derived microvesicles are associated with disease severity in COPD
T2  - American Journal of Physiology: Lung Cellular and Molecular Physiology
UR  - http://dx.doi.org/10.1152/ajplung.00099.2020
UR  - https://journals.physiology.org/doi/full/10.1152/ajplung.00099.2020
UR  - http://hdl.handle.net/10044/1/85018
VL  - 320
ER  -
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