Publications
282 results found
Engineer N, Sooranna SR, Bennett PR, et al., 2004, The effect of anisomycin on MAPK activity in uterine smooth muscle cells., 51st Annual Meeting of the Society-for-Gynecologic-Investigation, Publisher: ELSEVIER SCIENCE INC, Pages: 74A-74A, ISSN: 1071-5576
Sooranna SR, Bennett PR, Johnson MR, 2004, Phosphorylation and activation of mitogen-activated protein kinase pathways in response to mechanical stretch and interleukin-1<i>beta</i> stimulation in human myometrium., 51st Annual Meeting of the Society-for-Gynecologic-Investigation, Publisher: ELSEVIER SCIENCE INC, Pages: 334A-335A, ISSN: 1071-5576
Terzidou V, Soorana SS, Johnson M, et al., 2004, Expression of RIP140 in human primary myocytes in relation to pregnancy, labour and mechanical stretch., 51st Annual Meeting of the Society-for-Gynecologic-Investigation, Pages: 235A-235A
Sooranna SR, Sun K, Bennett PR, et al., 2004, Expression of cPLA<sub>2</sub>, PGES-1 and PGES-2 before and after mechanical stretch of cultured human uterine myocytes., 51st Annual Meeting of the Society-for-Gynecologic-Investigation, Publisher: ELSEVIER SCIENCE INC, Pages: 81A-81A, ISSN: 1071-5576
Chakravati S, Sooranna SR, Bennett PR, et al., 2004, Serine 505 phosphorylation of cytosolic phospholipase A<sub>2</sub> by interleukin-1<i>beta</i> and mechanical stretch in uterine smooth muscle., 51st Annual Meeting of the Society-for-Gynecologic-Investigation, Publisher: ELSEVIER SCIENCE INC, Pages: 72A-72A, ISSN: 1071-5576
Mohan AR, Sooranna SR, Lee YS, et al., 2004, The effect of mechanical stretch on NFκB DNA binding in human amnion., 51st Annual Meeting of the Society-for-Gynecologic-Investigation, Publisher: ELSEVIER SCIENCE INC, Pages: 302A-302A, ISSN: 1071-5576
Sooranna SR, Lee Y, Kim LU, et al., 2004, Mechanical stretch activates type 2 cyclooxygenase via activator protein-1 transcription factor in human myometrial cells, MOLECULAR HUMAN REPRODUCTION, Vol: 10, Pages: 109-113
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- Citations: 87
Anim-Nyame N, Sooranna SR, Johnson MR, et al., 2004, Garlic supplementation increases peripheral blood flow: a role for interleukin-6?, JOURNAL OF NUTRITIONAL BIOCHEMISTRY, Vol: 15, Pages: 30-36, ISSN: 0955-2863
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- Citations: 16
Anim-Nyame N, Sooranna SR, Johnson MR, et al., 2004, Impaired retrograde transmission of vasodilatory signals via the endothelium in pre-eclampsia: a cause of reduced tissue blood flow?, CLINICAL SCIENCE, Vol: 106, Pages: 19-25, ISSN: 0143-5221
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- Citations: 11
Anim-Nyame N, Hills FA, Sooranna SR, et al., 2003, The relationship between insulin and insulin-like growth factor binding protein-1 is modified by pre-eclampsia, GYNECOLOGICAL ENDOCRINOLOGY, Vol: 17, Pages: 471-476, ISSN: 0951-3590
Anim-Nyame N, Gamble J, Sooranna SR, et al., 2003, Microvascular permeability is related to circulating levels of tumour necrosis factor-α in pre-eclampsia, CARDIOVASCULAR RESEARCH, Vol: 58, Pages: 162-169, ISSN: 0008-6363
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- Citations: 52
Anim-Nyame N, Gamble J, Sooranna SR, et al., 2003, Evidence of impaired microvascular function in pre-eclampsia: a non-invasive study, CLINICAL SCIENCE, Vol: 104, Pages: 405-412, ISSN: 0143-5221
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- Citations: 16
Loudon JAZ, Sooranna SR, Bennett PR, et al., 2003, Changes in progesterone receptor isoforms in cultured human uterine smooth muscle cells with pregnancy, mechanical stretch and labour at term, Journal of Obstetrics and Gynaecology, Vol: 23, Pages: S59-S59, ISSN: 0144-3615
There is no detectable progesterone withdrawal in maternal serum at the onset of parturition. However, antiprogestagens cause cervical ripening at term and may cause abortion at other gestations. Therefore, it is likely that withdrawal occurs at a cellular or receptor level. Oestrogen receptors (ER) regulate genes which cause myometrium to become contractile, whereas progesterone and its receptors (PR) are thought to contribute to quiescence. We demonstrate in this study that in cultured myocytes taken from lower segment biopsies at the time of caesarean section before or after labour or from hysterectomy specimens, receptor isoforms change, causing a functional progesterone withdrawal. There was no difference between PR isofroms from hysterectomy specimens and at term before labour. Although there was an increase in both PR-A and PR-B isoforms with labour, there was in increase in PR-A to -B ratio from 20 to 65. ER expression decreases and is almost undetectable during pregnancy. Myometrial cells stretched for 6 hours show that expression of PR-A remains unchanged, whereas PR-B is downregulated. © 2003, Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. All rights reserved.
Johnson MR, Anim-Nyame N, Johnson P, et al., 2002, Does endothelial cell activation occur with intrauterine growth restriction?, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 109, Pages: 836-839, ISSN: 1470-0328
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- Citations: 65
Anim-Nyame N, Sooranna SR, Jones J, et al., 2002, Longitudinal study of biochemical markers of bone turnover during normal pregnancy and pregnancies complicated by pre-eclampsia, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 109, Pages: 708-713, ISSN: 1470-0328
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- Citations: 18
Steel JH, Soorana SR, Kennea NL, et al., 2002, Bacteria in preterm fetal membranes detected, using fluorescence in situ hybridisation, with and without inflammation, Publisher: INT PEDIATRIC RESEARCH FOUNDATION, INC, Pages: 264A-264A, ISSN: 0031-3998
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- Citations: 1
Bajoria R, Sooranna SR, Ward BS, et al., 2002, Prospective function of placental leptin at maternal-fetal interface, PLACENTA, Vol: 23, Pages: 103-115, ISSN: 0143-4004
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- Citations: 87
Bajoria R, Sooranna SR, Ward S, et al., 2002, Placenta as a link between amino acids, insulin-IGF axis, and low birth weight: Evidence from twin studies, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 87, Pages: 308-315, ISSN: 0021-972X
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- Citations: 38
Bajoria R, Sooranna SR, Ward S, et al., 2001, Placental transport rather than maternal concentration of amino acids regulates fetal growth in monochorionic twins: Implications for fetal origin hypothesis, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, Vol: 185, Pages: 1239-1246, ISSN: 0002-9378
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- Citations: 46
Anim-Nyame N, Sooranna SR, Johnson MR, et al., 2001, Does interleukin-6 mediate the cardiovascular effects of garlic supplementation?, CIRCULATION, Vol: 104, Pages: 835-835, ISSN: 0009-7322
Bajoria R, Ward S, Sooranna SR, 2001, Atrial natriuretic peptide mediated polyuria: Pathogenesis of polyhydramnios in the recipient twin of twin-twin transfusion syndrome, PLACENTA, Vol: 22, Pages: 716-724, ISSN: 0143-4004
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- Citations: 35
Bajoria R, Gibson MJ, Ward S, et al., 2001, Placental regulation of insulin-like growth factor axis in monochorionic twins with chronic twin-twin transfusion syndrome, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 86, Pages: 3150-3156, ISSN: 0021-972X
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- Citations: 24
Anim-Nyame N, Sooranna SR, Johnson MR, et al., 2001, A longitudinal study of resting peripheral blood flow in normal pregnancy and pregnancies complicated by chronic hypertension and pre-eclampsia, CARDIOVASCULAR RESEARCH, Vol: 50, Pages: 603-609, ISSN: 0008-6363
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- Citations: 30
Sooranna SR, Ward S, Bajoria R, 2001, Fetal leptin influences birth weight in twins with discordant growth, PEDIATRIC RESEARCH, Vol: 49, Pages: 667-672, ISSN: 0031-3998
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- Citations: 29
Sooranna SR, Ward S, Bajoria R, 2001, Discordant fetal leptin levels in monochorionic twins with chronic midtrimester twin-twin transfusion syndrome, PLACENTA, Vol: 22, Pages: 392-398, ISSN: 0143-4004
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- Citations: 16
Westwood M, Gibson JM, Sooranna SR, et al., 2001, Genes or placenta as modulator of fetal growth: evidence from the insulin-like growth factor axis in twins with discordant growth, MOLECULAR HUMAN REPRODUCTION, Vol: 7, Pages: 387-395, ISSN: 1360-9947
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- Citations: 32
Bajoria R, Lazda EJ, Ward S, et al., 2001, Iron metabolism in monochorionic twin pregnancies in relation to twin-twin transfusion syndrome, HUMAN REPRODUCTION, Vol: 16, Pages: 567-573, ISSN: 0268-1161
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- Citations: 10
Bajoria R, Ward S, Sooranna SR, 2001, Erythropoietin in monochorionic twin pregnancies in relation to twin-twin transfusion syndrome, HUMAN REPRODUCTION, Vol: 16, Pages: 574-580, ISSN: 0268-1161
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- Citations: 12
Anim-Nyame N, Sooranna SR, Jones J, et al., 2001, Biochemical markers of maternal bone turnover are elevated in pre-eclampsia, BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 108, Pages: 258-262, ISSN: 0306-5456
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- Citations: 13
Bajoria R, Hancock M, Ward S, et al., 2000, Discordant amino acid profiles in monochorionic twins with twin-twin transfusion syndrome, PEDIATRIC RESEARCH, Vol: 48, Pages: 821-828, ISSN: 0031-3998
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- Citations: 22
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