Imperial College London
Alternate

DrDevSooranna

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Research Fellow
 
 
 
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Contact

 

+44 (0)20 8846 7895s.sooranna Website

 
 
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Location

 

H.3.36Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Publication Type
Year
to

282 results found

Anim-Nyame N, Sooranna SR, Johnson MR, Gamble J, Steer PJet al., 2000, Resting peripheral blood flow in normal pregnancy and in pre-eclampsia, CLINICAL SCIENCE, Vol: 99, Pages: 505-510, ISSN: 0143-5221

Journal article

Anim-Nyame N, Hills FA, Sooranna SR, Steer PJ, Johnson MRet al., 2000, A longitudinal study of maternal plasma insulin-like growth factor binding protein-1 concentrations during normal pregnancy and pregnancies complicated by pre-eclampsia, HUMAN REPRODUCTION, Vol: 15, Pages: 2215-2219, ISSN: 0268-1161

Journal article

Anim-Nyame N, Sooranna SR, Steer PJ, Johnson MRet al., 2000, Longitudinal analysis of maternal plasma leptin concentrations during normal pregnancy and pre-eclampsia, HUMAN REPRODUCTION, Vol: 15, Pages: 2033-2036, ISSN: 0268-1161

Journal article

Eaton BM, Sooranna SR, 2000, Transport of large neutral amino acids into BeWo cells, PLACENTA, Vol: 21, Pages: 558-564, ISSN: 0143-4004

Journal article

Anim-Nyame N, Sooranna SR, Gamble J, Steer PJet al., 2000, Changes in resting calf blood flow in normal pregnancy, chronic hypertension and pre-eclampsia, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 525, Pages: 10P-10P, ISSN: 0022-3751

Journal article

Ogueh O, Sooranna S, Nicolaides KH, Johnson MRet al., 2000, The relationship between leptin concentration and bone metabolism in the human fetus, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 85, Pages: 1997-1999, ISSN: 0021-972X

Journal article

Sooranna SR, 1999, The 4th Conference of the International Federation of Placental Associations, Tokyo, Japan, 1-3 October 1998., Placenta, Vol: 20, Pages: 281-284, ISSN: 0143-4004

Journal article

Sooranna SR, Oteng-Ntim E, Meah R, Ryder TA, Bajoria Ret al., 1999, Characterization of human placental explants: morphological, biochemical and physiological studies using first and third trimester placenta, HUMAN REPRODUCTION, Vol: 14, Pages: 536-541, ISSN: 0268-1161

Journal article

Eaton BM, Sooranna SR, 1998, <i>In vitro</i> modulation of L-arginine transport in trophoblast cells by glucose, EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol: 28, Pages: 1006-1010, ISSN: 0014-2972

Journal article

Eaton BM, Sooranna SR, 1998, Regulation of the choline transport system in superfused microcarrier cultures of BeWo cells, PLACENTA, Vol: 19, Pages: 663-669, ISSN: 0143-4004

Journal article

Sooranna SR, Hirani J, Das I, 1998, The role of polyamines in pregnancy., Biochem Soc Trans, Vol: 26, ISSN: 0300-5127

Journal article

Sooranna SR, Patel S, Das I, 1997, The effect of garlic on cell growth and cell division in cultured trophoblast and endothelial cell lines., Biochem Soc Trans, Vol: 25, ISSN: 0300-5127

Journal article

Bajoria R, Sooranna SR, Contractor SF, 1997, Endocytotic uptake of small unilamellar liposomes by human trophoblast cells in culture, HUMAN REPRODUCTION, Vol: 12, Pages: 1343-1348, ISSN: 0268-1161

Journal article

Das I, Patel S, Sooranna SR, 1997, Effects of aspirin and garlic on cyclooxygenase-induced chemiluminescence in human term placenta., Biochem Soc Trans, Vol: 25, ISSN: 0300-5127

Journal article

Das I, Hirani J, Sooranna S, 1996, Arginine is not responsible for the activation of nitric oxide synthase by garlic, JOURNAL OF ETHNOPHARMACOLOGY, Vol: 53, Pages: 5-9, ISSN: 0378-8741

Journal article

Eaton BM, Sooranna SR, 1996, Characterization of the choline transport system in superfused microcarrier cultures of BeWo choriocarcinoma cells, Scientific Meeting of the Physiological-Society, Publisher: CAMBRIDGE UNIV PRESS, Pages: P40-P40, ISSN: 0022-3751

Conference paper

Kumpel BM, Sooranna SR, 1996, Transcytosis ofIgG anti-D by human term trophoblast cells in culture, TRANSFUSION MEDICINE, Vol: 6, Pages: 115-120, ISSN: 0958-7578

Journal article

Morris NH, Sooranna SR, Steer PJ, Warren JBet al., 1996, The effect of the menstrual cycle on exhaled nitric oxide and urinary nitrate concentration, EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol: 26, Pages: 481-484, ISSN: 0014-2972

Journal article

Bajoria R, Sooranna SR, Contractor SF, 1996, Differential binding of warfarin to maternal, foetal and non-pregnant sera and its clinical implications, JOURNAL OF PHARMACY AND PHARMACOLOGY, Vol: 48, Pages: 486-491, ISSN: 0022-3573

Journal article

Eaton BM, Sooranna SR, 1996, Superfused microcarrier cultures of choriocarcinoma cells: A dynamic model for studying transport of glucose and amino acids, PLACENTA, Vol: 17, Pages: 209-215, ISSN: 0143-4004

Journal article

Baldeweg T, Sooranna S, Das I, Catalan J, Gazzard Bet al., 1996, Serum nitrite concentration suggests a role for nitric oxide in AIDS, AIDS, Vol: 10, Pages: 451-452, ISSN: 0269-9370

Journal article

Ramsay B, Sooranna SR, Johnson MR, 1996, Nitric oxide synthase activities in human myometrium and villous trophoblast throughout pregnancy, OBSTETRICS AND GYNECOLOGY, Vol: 87, Pages: 249-253, ISSN: 0029-7844

Journal article

Sooranna SR, Eaton BM, 1996, Superfused Microcarrier Cultures of BeWo Choriocarcinoma Cells : A Dynamic Model for Studies of Human Trophoblast Function., Methods Mol Med, Vol: 2, Pages: 465-476, ISSN: 1543-1894

The human placenta is a unique and still very poorly understood organ During gestation, it is responsible for performing most synthetic and transport functions that are necessary to ensure the normal growth and development of the fetus in utero. Subsequently, at birth it is discarded. Current understanding of the role of the placenta in maintaining fetal homeostasis is based primarily on studies using either artificially perfused term placental lobules, placental slices or explants, or isolated plasma membrane fractions (1-3). Studies with placental tissue are complicated by the presence of serial tissue layers in the maternofetal barrier, i e., syncytiotrophoblast, cytotrophoblast, and fetal endothelium, as well as by the presence of other cell types within the placental tissue, such as the Hofbauer cells or placental macrophages.

Journal article

Sooranna SR, 1996, Preparation of human trophoblast cells for culture., Methods Mol Med, Vol: 2, Pages: 457-464, ISSN: 1543-1894

The difficulty in obtaining a preparation of pure trophoblast cells for culture can be appreciated by understanding the structure of the placenta. The outer surface of the chorionic villi is covered by the syncytiotrophoblast, underlying which is a single cell layer of cytotrophoblast cells that sits on the basement membrane. Microvascular vessels connect this cell layer to the umbilical arteries and vein. The apical membrane of the syncytiotrophoblast is folded into numerous microvilli, and this layer forms a syncytium. Disaggregation of this villous tissue results in a broken syncytial membrane, releasing not only the cytotrophoblastic cells, but also the rest of the villous cell population (i.e., Hofbauer cells or macrophages, fibroblasts, grant cells, some adhering decidual and endothelial cells) as well as DNA from the nuclei of the syncytium. Separation of trophoblast from this heterogeneous cell population has proven to be a challenge.

Journal article

Sooranna SR, Hirani J, Das I, 1995, Garlic can induce both GTP cyclohydrolase and nitric oxide synthase activity in choriocarcinoma cells., 655th Meeting of the Biochemical-Society, Publisher: PORTLAND PRESS, Pages: S543-S543, ISSN: 0300-5127

Conference paper

Sooranna SR, Hirani J, Das I, 1995, Garlic can induce both GTP cyclohydrolase and nitric oxide synthase activity in choriocarcinoma cells., Biochem Soc Trans, Vol: 23, ISSN: 0300-5127

Journal article

MORRIS NH, BURSTON D, RAMSAY B, SOORANNA SRet al., 1995, FREE AMINO-ACID-CONCENTRATIONS IN NORMAL AND ABNORMAL 3RD TRIMESTER PLACENTAL VILLI, EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol: 25, Pages: 796-798, ISSN: 0014-2972

Journal article

MORRIS NH, SOORANNA SR, LEARMONT JG, POSTON L, RAMSEY B, PEARSON JD, STEER PJet al., 1995, NITRIC-OXIDE SYNTHASE ACTIVITIES IN PLACENTAL TISSUE FROM NORMOTENSIVE, PREECLAMPTIC AND GROWTH-RETARDED PREGNANCIES, BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 102, Pages: 711-714, ISSN: 0306-5456

Journal article

DAS I, KHAN NS, PURI BK, SOORANNA SR, DEBELLEROCHE J, HIRSCH SRet al., 1995, ELEVATED PLATELET CALCIUM MOBILIZATION AND NITRIC-OXIDE SYNTHASE ACTIVITY MAY REFLECT ABNORMALITIES IN SCHIZOPHRENIC BRAIN, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 212, Pages: 375-380, ISSN: 0006-291X

Journal article

SOORANNA SR, DAS I, 1995, THE INTERRELATIONSHIP BETWEEN POLYAMINES AND THE L-ARGININE NITRIC-OXIDE PATHWAY IN THE HUMAN PLACENTA, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 212, Pages: 229-234, ISSN: 0006-291X

Journal article

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