Publications
215 results found
Faulkner L, Altmann DM, Ellmerich S, et al., 2007, Sexual dimorphism in superantigen shock involves elevated TNF-α and TNF-α-induced hepatic apoptosis, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 176, Pages: 473-482, ISSN: 1073-449X
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- Citations: 21
Turner C, Sriskandan S, 2007, <i>Streptococcus pyogenes</i> under pressure, NATURE MEDICINE, Vol: 13, Pages: 909-910, ISSN: 1078-8956
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- Citations: 1
Edwards RJ, Wrigley A, Bai Z, et al., 2007, C-Terminal antibodies (CTAbs): A simple and broadly applicable approach for the rapid generation of protein-specific antibodies with predefined specificity, PROTEOMICS, Vol: 7, Pages: 1364-1372, ISSN: 1615-9853
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- Citations: 7
Curtis SJ, Tanna A, Russell HH, et al., 2007, Invasive group A streptococcal infection in injecting drug users and non-drug users in a single UK city, JOURNAL OF INFECTION, Vol: 54, Pages: 422-426, ISSN: 0163-4453
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- Citations: 19
Lundberg KE, Kinloch A, Allison HE, et al., 2007, Mapping of citrullinated α-enolase antibodies to an immunodominant epitope with high sequence similarity to bacterial enolase, Annual Meeting of the British-Society-of-Rheumatology, Publisher: OXFORD UNIV PRESS, Pages: I12-I12, ISSN: 1462-0324
Lundberg K, Kinloch A, Allison H, et al., 2007, Mapping of citrullinated alpha-enolase antibodies to an immunodominant epitope with high sequence similarity to bacterial enolase, 27th European Workshop for Rheumatology Research, Publisher: B M J PUBLISHING GROUP, Pages: A18-A19, ISSN: 0003-4967
Llewelyn M, Sriskandan S, Terrazzini N, et al., 2007, The Vβ specific response to bacterial superantigens is determined by concentration and HLA class II, Annual Congress of the British-Society-of-Immunology, Publisher: BLACKWELL PUBLISHING, Pages: 77-77, ISSN: 0019-2805
Cartwright N, McMaster SK, Sorrentino R, et al., 2007, Elucidation of Toll-like receptor and adapter protein signaling in vascular dysfunction induced by Gram-positive <i>Staphylococcus aureus</i> or Gram-negative <i>Escherichia coli</i>, SHOCK, Vol: 27, Pages: 40-47, ISSN: 1073-2322
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- Citations: 33
Sriskandan S, 2007, Human intravenous immunoglobulin for experimental streptococcal toxic shock: bacterial clearance and modulation of inflammation - author's response, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol: 59, Pages: 159-160, ISSN: 0305-7453
Sriskandan S, Faulkner L, Hopkins P, 2007, <i>Streptococcus pyogenes</i>:: Insight into the function of the streptococcal superantigens, INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, Vol: 39, Pages: 12-19, ISSN: 1357-2725
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- Citations: 44
Efstratiou A, Sriskandan S, Lamagni T, et al., 2006, β-Haemolytic Streptococci, Principles and Practice of Clinical Bacteriology: Second Edition, Pages: 1-20, ISBN: 9780470849767
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- Citations: 3
Latifi-Navid S, Siavoshi F, Safari F, et al., 2006, Antimicrobial effectiveness of ketoconazole against metronidazole-resistant Helicobacter pylori isolates from Iranian dyspeptic patients, Journal of Antimicrobial Chemotherapy, Vol: 59, Pages: 160-161, ISSN: 0305-7453
Llewelyn M, Sriskandan S, Terrazzini N, et al., 2006, The TCR Vβ signature of bacterial superantigens spreads with stimulus strength, INTERNATIONAL IMMUNOLOGY, Vol: 18, Pages: 1433-1441, ISSN: 0953-8178
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- Citations: 26
Paul-Clark MJ, Mc Master SK, Belcher E, et al., 2006, Differential effects of Gram-positive <i>versus</i> Gram-negative bacteria on NOSII and TNFα in macrophages:: role of TLRs in synergy between the two, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 148, Pages: 1067-1075, ISSN: 0007-1188
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- Citations: 45
Sriskandan S, Ferguson M, Elliot V, et al., 2006, Human intravenous immunoglobulin for experimental streptococcal toxic shock: bacterial clearance and modulation of inflammation, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol: 58, Pages: 117-124, ISSN: 0305-7453
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- Citations: 63
Yuste J, Ali S, Sriskandan S, et al., 2006, Roles of the alternative complement pathway and C1q during innate immunity to <i>Streptococcus pyogenes</i>, JOURNAL OF IMMUNOLOGY, Vol: 176, Pages: 6112-6120, ISSN: 0022-1767
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- Citations: 33
Sriskandan S, Slater JD, 2006, Invasive disease and toxic shock due to zoonotic Streptococcus suis: An emerging infection in the East?, PLOS Medicine, Vol: 3, Pages: 595-597, ISSN: 1549-1277
Faulkner L, Cooper A, Fantino C, et al., 2005, The mechanism of superantigen-mediated toxic shock: not a simple Th1 cytokine storm., J Immunol., Pages: 6870-6877
Edwards RJ, Taylor GW, Ferguson M, et al., 2005, Specific C-terminal cleavage and inactivation of interleukin-8 by invasive disease isolates of <i>Streptococcus pyogenes</i>, JOURNAL OF INFECTIOUS DISEASES, Vol: 192, Pages: 783-790, ISSN: 0022-1899
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- Citations: 137
Hopkins PA, Sriskandan S, 2005, Mammalian Toll-like receptors: to immunity and beyond, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 140, Pages: 395-407, ISSN: 0009-9104
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- Citations: 166
Hopkins PA, Fraser JD, Pridmore AC, et al., 2005, Superantigen recognition by HLA class II on monocytes up-regulates toll-like receptor 4 and enhances proinflammatory responses to endotoxin, BLOOD, Vol: 105, Pages: 3655-3662, ISSN: 0006-4971
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- Citations: 40
Jimenez R, Belcher E, Sriskandan S, et al., 2005, Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 102, Pages: 4637-4642, ISSN: 0027-8424
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- Citations: 47
Hopkins P, Pridmore A, Reid R, et al., 2004, Pattern-recognition of superantigens by MHC class II receptors on human monocytes facilitates pro-inflammatory synergy with endotoxin and parallel up-regulation of toll-like receptor 4, Spring Meeting of the Intensive-Care-Society, Publisher: OXFORD UNIV PRESS, Pages: 314P-314P, ISSN: 0007-0912
Llewelyn M, Sriskandan S, Peakman M, et al., 2004, HLA class II polymorphisms determine responses to bacterial superantigens, JOURNAL OF IMMUNOLOGY, Vol: 172, Pages: 1719-1726, ISSN: 0022-1767
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- Citations: 74
Proft T, Sriskandan S, Yang L, et al., 2003, Superantigens and streptococcal toxic shock syndrome, Emerging Infectious Diseases, Vol: 9, Pages: 1211-1218, ISSN: 1080-6059
Superantigens produced by Streptococcus pyogenes have been implicated with streptococcal toxic shock syndrome (STSS). We analyzed 19 acute-phase serum samples for mitogenic activity from patients with severe streptococcal disease. The serum samples from two patients in the acute phase of STSS showed strong proliferative activity. Streptococcal mitogenic exotoxin (SME) Z-1 and streptococcal pyrogenic exotoxin (SPE)-J were identified in one patient with peritonitis who recovered after 2 weeks in intensive care. SMEZ-16 was found in a second patient who died on the day of admission. Sequential serum samples taken on day 3 after admission from patient 1 showed clearance of mitogenic activity but absence of neutralizing anti-SMEZ antibodies. Serum samples taken on day 9 from this patient showed evidence of seroconversion with high levels of anti-SMEZ antibodies that neutralized SMEZ-1 and 12 other SMEZ-variants. These results imply that a high level of SMEZ production by group A streptococcus is a causative event in the onset and subsequent severity of STSS.
Anandarajah J, Fleet MR, Walters MJ, et al., 2003, Gram positive and Gram negative bacteria synergise to cause nitric oxide synthase induction in murine macrophages, Meeting of the British-Pharmacological-Society, Publisher: NATURE PUBLISHING GROUP, ISSN: 0007-1188
Fleet MR, Anandarajah J, Walters MJ, et al., 2003, Cigarette smoke inhibits the induction of NOSII activity in murine macrophages stimulated with Gram negative bacteria, Meeting of the British-Pharmacological-Society, Publisher: NATURE PUBLISHING GROUP, ISSN: 0007-1188
Belcher E, Evans TW, Sriskandan S, et al., 2003, Staphylococcus aureus induces nitric oxide release in cardiovascular tissue via a toll like receptor 2-independent pathway, Meeting of the British-Pharmacological-Society-Clinical-Pharmacology-Section, Publisher: WILEY, Pages: U16-U16, ISSN: 0007-1188
Hopkins P, Sriskandan S, 2003, The synergistic up-regulation of the proinflammatory innate response by Gram-positive superantigens and endotoxin, Meeting of the Intensive-Care-Society, Publisher: ELSEVIER SCI LTD, Pages: 555P-555P, ISSN: 0007-0912
Belcher E, Evans TW, Sriskandan S, et al., 2003, Escherichia coli induces nitric oxide release in cardiovascular tissue via a toll like receptor 4-independent pathway, Meeting of the British-Pharmacological-Society-Clinical-Pharmacology-Section, Publisher: WILEY, Pages: U16-U16, ISSN: 0007-1188
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