Imperial College London
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ProfessorShiraneeSriskandan

Faculty of Medicine, Department of Infectious Disease

Professor of Infectious Diseases
 
 
 
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Contact

 

s.sriskandan

 
 
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Assistant

 

Ms Teyanna Gaeta +44 (0)20 3313 1943

 
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Location

 

8N21ACWBCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Parks:2020,
author = {Parks, T and Elliot, K and Lamagni, T and Auckland, K and Mentzer, AJ and Guy, R and Cartledge, D and Strakova, L and O'Connor, D and Pollard, AJ and Neville, MJ and Mahajan, A and Ashrafian, H and Chapman, SJ and Hill, AVS and Sriskandan, S and Knight, JC},
journal = {Genes and Immunity},
pages = {63--70},
title = {Elevated risk of invasive group a streptococcal disease and host genetic variation in the human leukocyte antigen locus},
url = {https://www.nature.com/articles/s41435-019-0082-z},
volume = {21},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Invasive group A streptococcal (GAS) disease is uncommon but carries a high casefatality rate relative to other infectious diseases. Given the ubiquity of mild GASinfections, it remains unclear why healthy individuals will occasionally develop lifethreatening infections, raising the possibility of host genetic predisposition. Here, wepresent the results of a case-control study including 43 invasive GAS cases and1,540 controls. Using HLA imputation and linear mixed-models, we find each copy ofthe HLA-DQA101:03 allele associates with a two-fold increased risk of disease(odds ratio 2.3, 95% confidence interval 1.3-4.4, P=0.009), an association whichpersists with classical HLA typing of a subset of cases and analysis with analternative large control dataset with validated HLA data. Moreover, we propose theassociation is driven by the allele itself rather than the background haplotype. Overallthis finding provides impetus for further investigation of the immunogenetic basis ofthis devastating bacterial disease.
AU  - Parks,T
AU  - Elliot,K
AU  - Lamagni,T
AU  - Auckland,K
AU  - Mentzer,AJ
AU  - Guy,R
AU  - Cartledge,D
AU  - Strakova,L
AU  - O'Connor,D
AU  - Pollard,AJ
AU  - Neville,MJ
AU  - Mahajan,A
AU  - Ashrafian,H
AU  - Chapman,SJ
AU  - Hill,AVS
AU  - Sriskandan,S
AU  - Knight,JC
EP  - 70
PY  - 2020///
SN  - 1466-4879
SP  - 63
TI  - Elevated risk of invasive group a streptococcal disease and host genetic variation in the human leukocyte antigen locus
T2  - Genes and Immunity
UR  - https://www.nature.com/articles/s41435-019-0082-z
UR  - http://hdl.handle.net/10044/1/71595
VL  - 21
ER  -
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