Publications
651 results found
Jalan R, Turjanski N, TaylorRobinson SD, et al., 1997, Benzodiazepine receptor density is globally upregulated in chronic hepatic encephalopathy (CHE): A positron emission tomography (PET) study with C-11-flumazenil, Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: A51-A51, ISSN: 0017-5749
Jalan R, Turjanski N, TaylorRobinson SD, et al., 1997, Benzodiazepine receptor density is upregulated in CHE but does not correlate with changes in neuropsychological function following administration of flumazenil (FMZ), Publisher: W B SAUNDERS CO, Pages: 290-290, ISSN: 0270-9139
Hodgson RS, TaylorRobinson SD, Jackson JE, et al., 1997, Superior mesenteric vein stenosis complicating Crohn's disease, GUT, Vol: 41, Pages: A222-A222, ISSN: 0017-5749
TaylorRobinson SD, Buckley C, Changani KK, et al., 1997, Cerebral P-31 and H-1 MR spectroscopy in subclinical hepatic encephalopathy, Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: A235-A235, ISSN: 0017-5749
Barnard ML, Changani KK, TaylorRobinson SD, 1997, The role of magnetic resonance spectroscopy in the assessment of kidney viability, SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY, Vol: 31, Pages: 487-492, ISSN: 0036-5599
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- Citations: 7
TaylorRobinson SD, Buckley C, Changani KK, et al., 1997, Correlations between cerebral phosphorus-31 and proton MR spectroscopy in patients with subclinical hepatic encephalopathy, Publisher: W B SAUNDERS CO, Pages: 299-299, ISSN: 0270-9139
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- Citations: 15
Changani KK, Fuller BJ, Bell JD, et al., 1997, AMP regeneration following hypothermic reperfusion of stored donor livers: Potential for increasing storage times?, Publisher: W B SAUNDERS CO, Pages: 891-891, ISSN: 0270-9139
Davidson BR, Barnard ML, Changani KK, et al., 1997, Liver transplantation: current and potential applications of magnetic resonance spectroscopy., Liver Transpl Surg, Vol: 3, Pages: 481-493, ISSN: 1074-3022
Magnetic resonance spectroscopy (MRS) allows the noninvasive measurement of whole organ metabolism due to the presence of the MR-sensitive nucleus phosphorus 31 in adenosine triphosphate (ATP), its precursors, and break-down products. In small animal liver transplant studies it has been used to analyze the metabolic effects of cold and warm ischemia, hypothermic reperfusion, and the relative efficacy of different organ preservation solutions. In recent large animal studies MRS has been developed to provide continuous dynamic information on ATP metabolism during graft reperfusion and the bioenergetic consequences of altering preservation solutions. These basic experimental data need to be critically evaluated in human liver transplantation. Encouraging preliminary data on many possible clinical applications have already been obtained, such as the assessment of human donor liver viability and posttransplant graft function. At present, the cost and technically demanding nature of MRS may restrict its application to research units.
TaylorRobinson SD, Sargentoni J, Bell JD, et al., 1997, In vivo and in vitro hepatic P-31 magnetic resonance spectroscopy and electron microscopy of the cirrhotic liver, LIVER, Vol: 17, Pages: 198-209, ISSN: 0106-9543
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- Citations: 56
TaylorRobinson SD, Jackson N, Buckley C, 1997, Helicobacter pylori, ammonia and the brain, GUT, Vol: 40, Pages: 805-806, ISSN: 0017-5749
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- Citations: 20
Thompson GR, Scott J, Walport MJ, et al., 1997, Grand rounds - Hammersmith Hospital - Hazards of running a marathon - Creatine kinase MB can be raised without myocardial infarction, BRITISH MEDICAL JOURNAL, Vol: 314, Pages: 1023-1025, ISSN: 0959-8138
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- Citations: 10
Thompson GR, 1997, Grand rounds--Hammersmith Hospital. Hazards of running a marathon., BMJ, Vol: 314, Pages: 1023-1025, ISSN: 0959-8138
Weir A, TaylorRobinson SD, Poole S, et al., 1997, Cytoplasmic antineutrophil cytoplasmic antibody-positive vasculitis associated with ulcerative colitis, AMERICAN JOURNAL OF GASTROENTEROLOGY, Vol: 92, Pages: 506-508, ISSN: 0002-9270
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- Citations: 10
Changani KK, Fuller BJ, Bryant DJ, et al., 1997, Non-invasive assessment of ATP regeneration potential of the preserved donor liver. A 31P MRS study in pig liver., J Hepatol, Vol: 26, Pages: 336-342, ISSN: 0168-8278
We have developed a quick, non-invasive method for measuring the ability of an isolated preserved liver to regenerate high energy phosphate nucleotides without the need for biopsy. Using 31P MRS we have monitored the hepatic energetics of intact cold preserved pig liver using standard clinical harvesting and storage techniques. Following cold storage for 2 h the livers were hypothermically reperfused with oxygenated modified University of Wisconsin preservation fluid. Prior to reperfusion MRS detectable adenosine diphosphate plus adenosine triphosphate was negligible; however, the spectrum showed intense resonances from phosphomonoesters and inorganic phosphate, as a consequence of adenosine triphosphate hydrolysis during cold preservation. Following a 10-min period of hypothermic reperfusion, regeneration of adenosine triphosphate occurred with a concurrent decline in inorganic phosphate and phosphomonoester, both of which are associated with adenosine triphosphate synthesis. The capacity of the liver to regenerate adenosine triphosphate following a 24-h period of cold storage was reduced by approximately 40% (p < 0.01) of the total amount achieved following the shorter cold storage time. Adenosine triphosphate regeneration rates were biphasic and were decreased upon prolonged storage, with the initial rate being reduced from 40.6 x 10(-2).min-1 (standard deviation (sd) 2.70 x 10(-2).min-1) to 14.8 x 10(-2).min-1 (sd; 2.4 x 10(-2).min-1) and the secondary rate from 1.77 x 10(-2).min-1 (sd; 0.18 x 10(-2).min-1) to 0.84 x 10(-2).min-1 (sd; 0.45 x 10(-2).min-1). MR images of the liver during the period of hypothermic reperfusion were also performed providing an assessment for the degree of hepatic vascular perfusion. This non-invasive, 31P MRS assessment of hepatic energetics in a clinically relevant animal model has great potential for the understanding of graft preservation injury.
Changani KK, Fuller BJ, Bryant DJ, et al., 1997, Non-invasive assessment of ATP regeneration potential of the preserved donor liver - A P-31 MRS study in pig liver, JOURNAL OF HEPATOLOGY, Vol: 26, Pages: 336-342, ISSN: 0168-8278
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- Citations: 34
Thomas E, 1997, Changes in adipose tissue composition in malnourished patients before and after liver transplantation: A carbon-13 magnetic resonance spectroscopy and gas-liquid chromatography study, Hepatology, Vol: 25, Pages: 178-183, ISSN: 0270-9139
Thomas EL, TaylorRobinson SD, Barnard ML, et al., 1997, Changes in adipose tissue composition in malnourished patients before and after liver transplantation: A carbon-13 magnetic resonance spectroscopy and gas-liquid chromatography study, HEPATOLOGY, Vol: 25, Pages: 178-183, ISSN: 0270-9139
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- Citations: 18
Seery JP, Taylor-Robinson SD, 1996, The application of magnetic resonance spectroscopy to the study of hepatic encephalopathy., J Hepatol, Vol: 25, Pages: 988-998, ISSN: 0168-8278
Aspinall RJ, Seery JP, Taylor-Robinson SD, et al., 1996, Comments on "arterialization of the portal vein in orthotopic and auxiliary liver transplantation"., Transplantation, Vol: 62, Pages: 1375-1376, ISSN: 0041-1337
Aspinall RJ, Seery JP, TaylorRobinson SD, et al., 1996, Arterialization of the portal vein in orthotopic and auxiliary liver transplantation - Comment, TRANSPLANTATION, Vol: 62, Pages: 1375-1375, ISSN: 0041-1337
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- Citations: 22
Jalan R, Seery JP, TaylorRobinson SD, 1996, Review article: Pathogenesis and treatment of chronic hepatic encephalopathy, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 10, Pages: 681-697, ISSN: 0269-2813
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- Citations: 33
Jalan R, Turjanski N, TaylorRobinson SD, et al., 1996, Pathogenesis of chronic hepatic encephalopathy (CHE): A positron emission tomography (PET) with C-11-Flumazenil and H-1 magnetic resonance spectroscopic (MRS) study, Publisher: W B SAUNDERS CO, Pages: 1298-1298, ISSN: 0270-9139
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- Citations: 1
Changani KK, Fuller BJ, Bell JD, et al., 1996, Hepatic nucleotide triphosphate regeneration after hypothermic reperfusion in the pig model: an in vitro P-NMR study., Transplantation, Vol: 62, Pages: 787-793, ISSN: 0041-1337
The aim of this study was to assess the possibility of regenerating nucleotide triphosphates (NTP) in the pig liver following its harvest and subsequent storage on ice. This study has used a pig model that allowed human donor liver retrieval techniques and methods of storage to be utilized. In vitro phosphorus-31 nuclear magnetic resonance (31P-NMR) spectroscopy was used to evaluate the changes associated with phosphorus containing metabolites such as NTP, phosphomonoesters (PME), phosphodiesters (PDE), and inorganic phosphate (Po). During 4 hr storage NTP levels were reduced to undetectable levels but its regeneration was possible over a period of 2 hr of oxygenated hypothermic reperfusion. Resynthesized NTP reached values that were only 30% reduced from pre-harvest values. There was a corresponding reduction in Pi over the same period. Glycolytic intermediates, 3-phosphoglycerate and 2,3 diphosphoglycerate, both increased significantly during the period of storage and subsequently declined following hypothermic reperfusion. Cellular damage, indicated by the concentrations of glycerophosphorylcholine (GPC) and glycerophosphorylethanolamine (GPE) was minimal during cold storage. However upon hypothermic reperfusion, concentrations of GPC and GPE reduced, indicating a degree of cellular damage caused by reperfusion. This study has shown for the first time that is possible to regenerate high energy phosphate nucleotides following a period of hypothermic reperfusion in a large, clinically related animal model. This technique warrants investigation clinically to improve the outcome of orthotopic liver transplantation. It also provides a method to study the effects of different preservation fluids and methods of storage and organ reperfusion.
Changani KK, Fuller BJ, Bell JD, et al., 1996, Hepatic nucleotide triphosphate regeneration after hypothermic reperfusion in the pig model - An in vitro P-31-NMR study, TRANSPLANTATION, Vol: 62, Pages: 787-793, ISSN: 0041-1337
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- Citations: 25
Jalan R, Taylor-Robinson SD, Hodgson HJ, 1996, In vivo hepatic magnetic resonance spectroscopy: clinical or research tool?, J Hepatol, Vol: 25, Pages: 414-424, ISSN: 0168-8278
Lambiase P, Seery JP, TaylorRobinson SD, et al., 1996, Resolution of panniculitis after placement of pancreatic duct stent in chronic pancreatitis, AMERICAN JOURNAL OF GASTROENTEROLOGY, Vol: 91, Pages: 1835-1837, ISSN: 0002-9270
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- Citations: 23
TaylorRobinson SD, Sargentoni J, Oatridge A, et al., 1996, MR imaging and spectroscopy of the basal ganglia in chronic liver disease: Correlation of T-1-weighted contrast measurements with abnormalities in proton and phosphorus-31 MR spectra, METABOLIC BRAIN DISEASE, Vol: 11, Pages: 249-268, ISSN: 0885-7490
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- Citations: 42
Lambiase P, Seery JP, Taylor-Robinson SD, et al., 1996, Resolution of panniculitis after placement of pancreatic duct stent in chronic pancreatitis., Am J Gastroenterol, Vol: 91, Pages: 1835-1837, ISSN: 0002-9270
The association of panniculitis and pancreatitis is well described. However, panniculitis remains a relatively uncommon manifestation of pancreatic inflammation. We report a case in which treatment of pancreatitis by the placement of a pancreatic stent led to simultaneous resolution of both the pancreatitis and the associated panniculitis. There are no other reports in the literature demonstrating resolution of panniculitis subsequent to stent placement or definitive surgery.
deSouza NM, Wilson J, TaylorRobinson S, 1996, Endoscopic magnetic resonance imaging of the upper gastrointestinal tract, ENDOSCOPY, Vol: 28, Pages: 521-522, ISSN: 0013-726X
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- Citations: 1
Jalan R, Sargentoni J, Coutts GA, et al., 1996, Hepatic phosphorus-31 magnetic resonance spectroscopy in primary biliary cirrhosis and its relation to prognostic models, GUT, Vol: 39, Pages: 141-146, ISSN: 0017-5749
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- Citations: 36
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