Imperial College London
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ProfessorSimonTaylor-Robinson

Faculty of Engineering, Department of Electrical and Electronic Engineering

Visiting Professor
 
 
 
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Contact

 

s.taylor-robinson

 
 
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Location

 

Electrical EngineeringSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rice:2021:10.1016/j.cgh.2020.06.025,
author = {Rice, S and Albani, V and Minos, D and Fattakhova, G and Mells, GF and Carbone, M and Flack, S and Varvaropoulou, N and Badrock, J and Spicer, A and Sandford, RN and Shirley, MDF and Coughlan, D and Hirschfield, G and Taylor-Robinson, SD and Vale, L and Jones, DEJ},
doi = {10.1016/j.cgh.2020.06.025},
journal = {Clinical Gastroenterology and Hepatology},
pages = {768--776.e10},
title = {Effects of primary biliary cholangitis on quality of life and health care costs in the United Kingdom},
url = {http://dx.doi.org/10.1016/j.cgh.2020.06.025},
volume = {19},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background & Aims: There have been few high-quality studies of the costs, preference-based health-related quality of life (HRQoL) and cost effectiveness of treatments for primary biliary cholangitis (PBC). We aimed to estimate the marginal effects of PBC complications and symptoms, accounting for treatment, on HRQoL and the annual cost of health care in the United Kingdom (UK). These are essential components for evaluation of cost effectiveness and this information will aid in evaluation of new treatments.Methods: Questionnaires were mailed to 4583 participants in the UK-PBC research cohort and data were collected on HRQoL and use of the National Health Service (NHS) in the UK from 2015 through 2016. HRQoL was measured using the EQ-5D-5L instrument. The annual cost of resource use was calculated using unit costs obtained from NHS sources. We performed econometric analyses to determine the effects of treatment, symptoms, complications, liver transplantation status, and patient characteristics on HRQoL and annual costs.Results: In an analysis of data from 2240 participants (over 10% of all UK PBC patients), we found that PBC symptoms have a considerable effect on HRQoL. Ursodeoxycholic acid therapy was associated with significantly higher HRQoL regardless of response status. Having had a liver transplant and ascites were also independently associated with reduced HRQoL. Having had a liver transplant (US$4294) and esophageal varices (US$3401) were the factors with the two greatest mean annual costs to the NHS. Symptoms were not independently associated with cost but were associated with reduction in HRQoL for patients, indicating the lack of effective treatments for PBC symptoms.Conclusions: In an analysis of data from 2240 participants in the UK PBC, we found that HRQoL and cost estimates provide greater insight into the relative importance of PBC-related symptoms and complications. These findings provide estimates for health technology assessments of new treatmen
AU  - Rice,S
AU  - Albani,V
AU  - Minos,D
AU  - Fattakhova,G
AU  - Mells,GF
AU  - Carbone,M
AU  - Flack,S
AU  - Varvaropoulou,N
AU  - Badrock,J
AU  - Spicer,A
AU  - Sandford,RN
AU  - Shirley,MDF
AU  - Coughlan,D
AU  - Hirschfield,G
AU  - Taylor-Robinson,SD
AU  - Vale,L
AU  - Jones,DEJ
DO  - 10.1016/j.cgh.2020.06.025
EP  - 776
PY  - 2021///
SN  - 1542-3565
SP  - 768
TI  - Effects of primary biliary cholangitis on quality of life and health care costs in the United Kingdom
T2  - Clinical Gastroenterology and Hepatology
UR  - http://dx.doi.org/10.1016/j.cgh.2020.06.025
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000630421700026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S1542356520308363
UR  - http://hdl.handle.net/10044/1/80947
VL  - 19
ER  -
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