Imperial College London
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ProfessorSimonTaylor-Robinson

Faculty of Engineering, Department of Electrical and Electronic Engineering

Visiting Professor
 
 
 
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s.taylor-robinson

 
 
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Location

 

Electrical EngineeringSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chowdhury:2021:10.1186/s43066-021-00098-4,
author = {Chowdhury, D and Mahmood, F and Edwards, C and Taylor-Robinson, SD},
doi = {10.1186/s43066-021-00098-4},
journal = {Egyptian Liver Journal},
pages = {1--9},
title = {Five-day outcome of hepatitis E-induced acute liver failure in the ICU},
url = {http://dx.doi.org/10.1186/s43066-021-00098-4},
volume = {11},
year = {2021}
}
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TY  - JOUR
AB  - BackgroundHepatitis E virus (HEV) is an important cause of acute liver failure (ALF) in Bangladesh with pregnant mothers being more vulnerable. As HEV occurs in epidemics, it limits medical capabilities in this resource-poor country. Cerebral oedema, resulting in raised intracranial pressure (ICP), is an important cause of morbidity and mortality. Practical treatments are currently few.To study the baseline characteristics and clinical outcome of HEV-induced ALF in a recent HEV epidemicTo detect raised ICP clinically and observe response to mannitol infusion.This was a prospective cohort study from June until August 2018 of 20 patients admitted to the intensive care unit (ICU) of a major Bangladeshi Referral Hospital with HEV-induced ALF. We diagnosed HEV infection by detecting serum anti-HEV IgM antibody. All were negative for hepatitis B surface antigen and hepatitis A IgM antibody. Data were collected on 5-day outcome after admission to ICU, monitoring all patients for signs of raised ICP. An intravenous bolus of 20% mannitol was administered at a single time point to patients with raised ICP.ResultsTwenty patients were included in the study. Ten (50%) patients, seven (70%) females, received mannitol infusion. HE worsened in eight (40%): seven female and three pregnant. Glasgow Coma scores deteriorated in six (30%): all (100%) females and three pregnant. Consciousness status was not significantly different between pregnant and non-pregnant subjects, nor between those who received mannitol and those who did not. Six patients met King’s College Criteria for liver transplantation.ConclusionsFemale patients had a worse outcome, but pregnancy status was not an additional risk factor in our cohort. Mannitol infusion was also not associated with a significant difference in outcome.
AU  - Chowdhury,D
AU  - Mahmood,F
AU  - Edwards,C
AU  - Taylor-Robinson,SD
DO  - 10.1186/s43066-021-00098-4
EP  - 9
PY  - 2021///
SN  - 2090-6226
SP  - 1
TI  - Five-day outcome of hepatitis E-induced acute liver failure in the ICU
T2  - Egyptian Liver Journal
UR  - http://dx.doi.org/10.1186/s43066-021-00098-4
UR  - https://eglj.springeropen.com/articles/10.1186/s43066-021-00098-4
UR  - http://hdl.handle.net/10044/1/88919
VL  - 11
ER  -
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