Imperial College London
Alternate

ProfessorSimonTaylor-Robinson

Faculty of Engineering, Department of Electrical and Electronic Engineering

Visiting Professor
 
 
 
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Contact

 

s.taylor-robinson

 
 
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Location

 

Electrical EngineeringSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brindley:2021:10.1038/s41572-021-00300-2,
author = {Brindley, PJ and Bachini, M and Ilyas, SI and Khan, SA and Loukas, A and Sirica, AE and Teh, BT and Wongkham, S and Gores, GJ},
doi = {10.1038/s41572-021-00300-2},
journal = {Nat Rev Dis Primers},
title = {Cholangiocarcinoma.},
url = {http://dx.doi.org/10.1038/s41572-021-00300-2},
volume = {7},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cholangiocarcinoma (CCA) is a highly lethal adenocarcinoma of the hepatobiliary system, which can be classified as intrahepatic, perihilar and distal. Each anatomic subtype has distinct genetic aberrations, clinical presentations and therapeutic approaches. In endemic regions, liver fluke infection is associated with CCA, owing to the oncogenic effect of the associated chronic biliary tract inflammation. In other regions, CCA can be associated with chronic biliary tract inflammation owing to choledocholithiasis, cholelithiasis, or primary sclerosing cholangitis, but most CCAs have no identifiable cause. Administration of the anthelmintic drug praziquantel decreases the risk of CCA from liver flukes, but reinfection is common and future vaccination strategies may be more effective. Some patients with CCA are eligible for potentially curative surgical options, such as resection or liver transplantation. Genetic studies have provided new insights into the pathogenesis of CCA, and two aberrations that drive the pathogenesis of non-fluke-associated intrahepatic CCA, fibroblast growth factor receptor 2 fusions and isocitrate dehydrogenase gain-of-function mutations, can be therapeutically targeted. CCA is a highly desmoplastic cancer and targeting the tumour immune microenvironment might be a promising therapeutic approach. CCA remains a highly lethal disease and further scientific and clinical insights are needed to improve patient outcomes.
AU  - Brindley,PJ
AU  - Bachini,M
AU  - Ilyas,SI
AU  - Khan,SA
AU  - Loukas,A
AU  - Sirica,AE
AU  - Teh,BT
AU  - Wongkham,S
AU  - Gores,GJ
DO  - 10.1038/s41572-021-00300-2
PY  - 2021///
TI  - Cholangiocarcinoma.
T2  - Nat Rev Dis Primers
UR  - http://dx.doi.org/10.1038/s41572-021-00300-2
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34504109
VL  - 7
ER  -
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