Imperial College London
Alternate

ProfessorSimonTaylor-Robinson

Faculty of Engineering, Department of Electrical and Electronic Engineering

Visiting Professor
 
 
 
//

Contact

 

s.taylor-robinson

 
 
//

Location

 

Electrical EngineeringSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Alfadda:2023:10.3389/fmolb.2023.1030661,
author = {Alfadda, AA and Almaghamsi, AM and Sherbeeni, SM and Alqutub, AN and Aldosary, AS and Isnani, AC and Al-Daghri, N and Taylor-Robinson, SD and Gul, R},
doi = {10.3389/fmolb.2023.1030661},
journal = {Frontiers in Molecular Biosciences},
pages = {1--14},
title = {Alterations in circulating lipidomic profile in patients with type 2 diabetes with or without non-alcoholic fatty liver disease},
url = {http://dx.doi.org/10.3389/fmolb.2023.1030661},
volume = {10},
year = {2023}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective: Non-alcoholic fatty liver disease (NAFLD) and Type 2 diabetes mellitus (T2DM) often coexist and drive detrimental effects in a synergistic manner. This study was designed to understand the changes in circulating lipid and lipoprotein metabolism in patients with T2DM with or without NAFLD.Methods: Four hundred thirty-four T2DM patients aged 18–60 years were included in this study. Fatty liver was assessed by FibroScan. The comprehensive metabolic lipid profiling of serum samples was assessed by using high-throughput proton NMR metabolomics.Results: Our data revealed a significant association between steatosis and serum total lipids in VLDL and LDL lipoprotein subclasses, while total lipids in HDL subclasses were negatively associated. A significant positive association was found between steatosis and concentration of lipids, phospholipids, cholesterol, and triglycerides in VLDL and LDL subclasses, while HDL subclasses were negatively associated. Furthermore, a significant, association was observed between fibrosis and concentrations of lipids, phospholipids, cholesterol, and triglycerides in very small VLDL, large, and very large HDL subclasses. Subgroup analysis revealed a decrease in the concentrations of lipids, phospholipids, cholesterol, and other lipid biomolecules in patients using antilipemic medications.Conclusion: The metabolomics results provide evidence that patients with T2DM with higher steatosis grades have altered lipid metabolomics compared to patients without steatosis. Increased lipid, phospholipids, cholesterol, and triglycerides concentration of VLDL and LDL subclasses are associated with steatosis in patients with T2DM.
AU  - Alfadda,AA
AU  - Almaghamsi,AM
AU  - Sherbeeni,SM
AU  - Alqutub,AN
AU  - Aldosary,AS
AU  - Isnani,AC
AU  - Al-Daghri,N
AU  - Taylor-Robinson,SD
AU  - Gul,R
DO  - 10.3389/fmolb.2023.1030661
EP  - 14
PY  - 2023///
SN  - 2296-889X
SP  - 1
TI  - Alterations in circulating lipidomic profile in patients with type 2 diabetes with or without non-alcoholic fatty liver disease
T2  - Frontiers in Molecular Biosciences
UR  - http://dx.doi.org/10.3389/fmolb.2023.1030661
UR  - https://www.frontiersin.org/articles/10.3389/fmolb.2023.1030661/full
UR  - http://hdl.handle.net/10044/1/103273
VL  - 10
ER  -
Download