Publications
147 results found
Ben-Sasi K, Chitty LS, Franck LS, et al., 2013, Acceptability of a minimally invasive perinatal/paediatric autopsy: healthcare professionals' views and implications for practice, PRENATAL DIAGNOSIS, Vol: 33, Pages: 307-312, ISSN: 0197-3851
- Author Web Link
- Cite
- Citations: 59
Pauliah SS, Shankaran S, Wade A, et al., 2013, Therapeutic hypothermia for neonatal encephalopathy in low- and middle-income countries: a systematic review and meta-analysis, PLoS ONE, Vol: 8, ISSN: 1932-6203
Although selective or whole body cooling combined with optimal intensive care improves outcomes following neonatal encephalopathy in high-income countries, the safety and efficacy of cooling in low-and middle-income countries is not known.Objective:We performed a systematic review and meta-analysis of all published randomised or quasi-randomised controlled trials of cooling therapy for neonatal encephalopathy in low-and middle-income countries.Results:Seven trials, comprising a total of 567 infants were included in the meta-analysis. Most study infants had mild (15%) or moderate encephalopathy (48%) and did not receive invasive ventilation (88%). Cooling devices included water-circulating cooling caps, frozen gel packs, ice, water bottles, and phase-changing material. No statistically significant reduction in neonatal mortality was seen with cooling (risk ratio: 0.74, 95% confidence intervals: 0.44 to 1.25). Data on other neonatal morbidities and long-term neurological outcomes were insufficient.Conclusion:Cooling therapy was not associated with a statistically significant reduction in neonatal mortality in low-and middle-income countries although the confidence intervals were wide and not incompatible with results seen in high-income countries. The apparent lack of treatment effect may be due to the heterogeneity and poor quality of the included studies, inefficiency of the low technology cooling devices, lack of optimal neonatal intensive care, sedation and ventilatory support, overuse of oxygen, or may be due to the intrinsic difference in the population, for example higher rates of perinatal infection, obstructed labor, intrauterine growth retardation and maternal malnutrition. Evaluation of the safety and efficacy of cooling in adequately powered randomised controlled trials is required before cooling is offered in routine clinical practice in low-and middle-income countries.
Soe A, Apampa B, Fernando B, et al., 2013, Interventions for reducing medication errors in children in hospital, Cochrane Database of Systematic Reviews, Vol: 2013, ISSN: 1465-1858
This is the protocol for a review and there is no abstract. The objectives are as follows: To determine the effectiveness of interventions to reduce medication errors (MEs) in hospitalised children.
Thayyil S, Sebire NJ, Chitty LS, 2013, Erratum: Post-mortem MRI versus conventional autopsy in fetuses and children: A prospective validation study (Lancet (2013) 382 (223-233)), The Lancet, Vol: 382, ISSN: 0140-6736
- Cite
- Citations: 1
Addison S, Sebire NJ, Taylor AM, et al., 2012, High quality genomic DNA extraction from postmortem fetal tissue, JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, Vol: 25, Pages: 2467-2469, ISSN: 1476-7058
- Author Web Link
- Cite
- Citations: 5
Arthurs O, Thayyil S, Wade A, et al., 2012, MR determination of neonatal spinal canal depth, EUROPEAN JOURNAL OF RADIOLOGY, Vol: 81, Pages: E813-E816, ISSN: 0720-048X
- Author Web Link
- Cite
- Citations: 1
Sebire NJ, Weber MA, Thayyil S, et al., 2012, Minimally invasive perinatal autopsies using magnetic resonance imaging and endoscopic postmortem examination ("keyhole autopsy"): feasibility and initial experience, JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, Vol: 25, Pages: 513-518, ISSN: 1476-7058
- Author Web Link
- Cite
- Citations: 64
Thayyil S, De Vita E, Sebire NJ, et al., 2012, Post-mortem cerebral magnetic resonance imaging <i>T</i><sub>1</sub> and <i>T</i><sub>2</sub> in fetuses, newborns and infants, EUROPEAN JOURNAL OF RADIOLOGY, Vol: 81, Pages: E232-E238, ISSN: 0720-048X
- Author Web Link
- Cite
- Citations: 25
Thayyil S, Sebire N, Ashworth MA, et al., 2012, Diagnostic accuracy of post-mortem cardiovascular magnetic resonance imaging in fetuses, newborns, and children, Journal of Cardiovascular Magnetic Resonance, Vol: 14, ISSN: 1097-6647
- Cite
- Citations: 1
Thayyil S, Sebire NJ, Chitty LS, et al., 2011, Post mortem magnetic resonance imaging in the fetus, infant and child: a comparative study with conventional autopsy (MaRIAS Protocol), BMC Pediatrics, Vol: 11, ISSN: 1471-2431
Background:Minimally invasive autopsy by post mortem magnetic resonance (MR) imaging has been suggested as an alternative for conventional autopsy in view of the declining consented autopsy rates. However, large prospective studies rigorously evaluating the accuracy of such an approach are lacking. We intend to compare the accuracy of a minimally invasive autopsy approach using post mortem MR imaging with that of conventional autopsy in fetuses, newborns and children for detection of the major pathological abnormalities and/or determination of the cause of death.Methods/Design:We recruited 400 consecutive fetuses, newborns and children referred for conventional autopsy to one of the two participating hospitals over a three-year period. We acquired whole body post mortem MR imaging using a 1.5 T MR scanner (Avanto, Siemens Medical Solutions, Enlargen, Germany) prior to autopsy. The total scan time varied between 90 to 120 minutes. Each MR image was reported by a team of four specialist radiologists (paediatric neuroradiology, paediatric cardiology, paediatric chest & abdominal imaging and musculoskeletal imaging), blinded to the autopsy data. Conventional autopsy was performed according to the guidelines set down by the Royal College of Pathologists (UK) by experienced paediatric or perinatal pathologists, blinded to the MR data. The MR and autopsy data were recorded using predefined categorical variables by an independent person.Discussion:Using conventional post mortem as the gold standard comparator, the MR images will be assessed for accuracy of the anatomical morphology, associated lesions, clinical usefulness of information and determination of the cause of death. The sensitivities, specificities and predictive values of post mortem MR alone and MR imaging along with other minimally invasive post mortem investigations will be presented for the final diagnosis, broad diagnostic categories and for specific diagnosis of each system.Clinical Trial Registration:
Thayyil S, Shankaran S, Cowan F, et al., 2011, BRAIN INJURY FOLLOWING WHOLE BODY COOLING AFTER NEONATAL ENCEPHALOPATHY IN A SOUTH INDIAN NEONATAL UNIT, PEDIATRIC RESEARCH, Vol: 70, Pages: 33-33, ISSN: 0031-3998
- Author Web Link
- Cite
- Citations: 3
Addison S, Sebire NJ, Judge-Kronis L, et al., 2011, GENOMIC DEOXYRIBONUCLEIC ACID EXTRACTION FROM POST MORTEM FETAL TISSUE, Publisher: NATURE PUBLISHING GROUP, Pages: 406-406, ISSN: 0031-3998
Chandrasekaran M, Thayyil S, Bainbridge A, et al., 2011, PROGNOSTIC ACCURACY OF THALAMIC PROTON MAGNETIC RESONANCE SPECTROSCOPY FOLLOWING THERAPEUTIC HYPOTHERMIA IN NEONATAL ENCEPHALOPATHY, Publisher: NATURE PUBLISHING GROUP, Pages: 161-161, ISSN: 0031-3998
Thayyil S, 2011, Less invasive autopsy: an evidenced based approach, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 96, Pages: 681-687, ISSN: 0003-9888
- Author Web Link
- Cite
- Citations: 17
Thayyil S, 2011, Brain cooling in babies: Are we ready for clinical trials in developing countries?, INDIAN PEDIATRICS, Vol: 48, Pages: 441-442, ISSN: 0019-6061
- Author Web Link
- Cite
- Citations: 1
Robertson NJ, Thayyil S, 2011, Hypothermic neural rescue for neonatal encephalopathy in mid- and low-resource settings, Neonatal Neural Rescue: A Clinical Guide, Pages: 128-141, ISBN: 9781107681606
The most significant burden of neonatal encephalopathy (NE) occurs in low- and mid-resource settings [1]. The WHO World Health Report 2005 estimated that an annual 1 million survivors of “birth asphyxia” may develop cerebral palsy, learning difficulties or other disabilities [2]. Globally, perinatal asphyxia is responsible for 42 million disability life adjusted years – this is double that due to diabetes and three quarters of that due to HIV/AIDS [1]. Almost one quarter of the world’s 4 million annual neonatal deaths are caused by perinatal asphyxia (Figures 12.1, 12.2) [3]: 99% of these deaths occur in low- and mid-resource settings especially those countries with higher neonatal mortality rates (Figures 12.1, 12.2). The potential benefits of therapeutic hypothermia (were it to be safe and effective in every setting) are potentially greater in low- and mid-resource settings where birth asphyxia is at least 10-fold higher than in the developed world. However, all the positive evidence about the safety and efficacy of cooling relates to high-income countries. Furthermore, there is a theoretical risk that problems such as immune suppression by hypothermia may be deleterious in a different setting; one pilot study in a low-resource setting [4] reported more deaths in the cooled group and the expensive high tech cooling devices used in the developed world are not appropriate for global use in low- and mid-resource settings.
Wilkinson DJ, Thayyil S, Robertson NJ, 2011, Ethical and practical issues relating to the global use of therapeutic hypothermia for perinatal asphyxial encephalopathy, ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, Vol: 96, Pages: F75-F78, ISSN: 1359-2998
- Author Web Link
- Cite
- Citations: 14
Thayyil S, Robertson NJ, Sebire NJ, et al., 2010, Post-mortem MR and CT imaging in fetuses, newborns and children: an evidenced based approach, Diagnostic Histopathology, Vol: 16, Pages: 565-572, ISSN: 1756-2317
There is insufficient evidence in the published literature to support the use of post-mortem MR imaging (MRI) as an alternative for conventional non-forensic autopsy in fetuses, newborns and children. Large prospective studies evaluating the accuracy of post-mortem MR imaging in a rigorous and blinded way are now nearing completion and the results are expected in 2011. Less-invasive autopsies by post-mortem MR imaging may have major effect in resurrecting consented autopsy rates; however an evidenced based and systematic approach towards less-invasive autopsy process is mandatory to ensure that the post-mortem data remains accurate and credible. Here we summarize the current evidence, ongoing research and future directions for less-invasive autopsy process in the United Kingdom. A joint effort between clinicians, radiologists, pathologists, parent groups and funding bodies is essential for successful implementation of less-invasive autopsy, in the UK. © 2010 Elsevier Ltd.
Robertson NJ, Kendall GS, Thayyil S, 2010, Techniques for therapeutic hypothermia during transport and in hospital for perinatal asphyxial encephalopathy, SEMINARS IN FETAL & NEONATAL MEDICINE, Vol: 15, Pages: 276-286, ISSN: 1744-165X
- Author Web Link
- Cite
- Citations: 27
Schievano S, Sebire NJ, Robertson NJ, et al., 2010, Reconstruction of fetal and infant anatomy using rapid prototyping of post-mortem MR images., Insights Imaging, Vol: 1, Pages: 281-286, ISSN: 1869-4101
OBJECTIVES: The recent decline in autopsy rates and lack of human anatomical material donated for research and training has resulted in issues for medical training in the United Kingdom. This study aims to examine the feasibility of making accurate three-dimensional (3D) models of the human body and visceral organs using post-mortem magnetic resonance (MR) imaging and rapid prototyping. METHODS: We performed post-mortem MR imaging using a 3D T2-weighted sequence in 11 fetuses and infants, before autopsy, using either a 1.5-T or 9.4-T MR scanner. Internal organs were reconstructed in silico and 3D models were created by rapid prototyping. RESULTS: The median gestation of fetuses was 20 (range 19-30) weeks and the median age of infants was 12 (range 8-16) weeks. Models created by rapid prototyping accurately depicted structural abnormalities and allowed clear visualisation of 3D relationships. CONCLUSIONS: Accurate 3D modelling of anatomical features from post-mortem imaging in fetuses and infants is feasible. These models could have a large number of medical applications, including improved parental counselling, invaluable teaching resources and significant medico-legal applications to demonstrate disease or injury, without the need to show actual autopsy photographs.
Thayyil S, Chitty LS, Robertson NJ, et al., 2010, Minimally invasive fetal postmortem examination using magnetic resonance imaging and computerised tomography: current evidence and practical issues, PRENATAL DIAGNOSIS, Vol: 30, Pages: 713-718, ISSN: 0197-3851
- Author Web Link
- Cite
- Citations: 50
Thayyil S, Chandrasekaran M, Chitty LS, et al., 2010, Diagnostic accuracy of post-mortem magnetic resonance imaging in fetuses, children and adults: A systematic review, EUROPEAN JOURNAL OF RADIOLOGY, Vol: 75, Pages: E142-E148, ISSN: 0720-048X
- Author Web Link
- Cite
- Citations: 54
Thayyil S, Bhutta ZA, Ramji S, et al., 2010, Global application of therapeutic hypothermia to treat perinatal asphyxial encephalopathy, INTERNATIONAL HEALTH, Vol: 2, Pages: 79-81, ISSN: 1876-3413
- Author Web Link
- Cite
- Citations: 4
Thayyil S, Robertson NJ, 2010, University College London (UCL) Symposia on Neonatal Neurology and Neuro Protection, INDIAN PEDIATRICS, Vol: 47, Pages: 395-395, ISSN: 0019-6061
Thayyil S, Chandrasekaran M, Taylor A, et al., 2010, Cerebral Magnetic Resonance Biomarkers in Neonatal Encephalopathy: A Meta-analysis, PEDIATRICS, Vol: 125, Pages: E382-E395, ISSN: 0031-4005
- Author Web Link
- Cite
- Citations: 258
Thayyil S, Cleary JO, Sebire NJ, et al., 2009, Postmortem Examination of Human Fetuses: A Comparison of Whole-Body High-Field MRI at 9.4 Tesla With Conventional MRI and Invasive Autopsy EDITORIAL COMMENT, OBSTETRICAL & GYNECOLOGICAL SURVEY, Vol: 64, Pages: 787-789, ISSN: 0029-7828
Thayyil S, Schievano S, Robertson NJ, et al., 2009, A semi-automated method for non-invasive internal organ weight estimation by post-mortem magnetic resonance imaging in fetuses, newborns and children, EUROPEAN JOURNAL OF RADIOLOGY, Vol: 72, Pages: 321-326, ISSN: 0720-048X
- Author Web Link
- Cite
- Citations: 31
Thayyil S, Cleary JO, Sebire NJ, et al., 2009, Post-mortem examination of human fetuses: a comparison of whole-body high-field MRI at 9.4 T with conventional MRI and invasive autopsy, LANCET, Vol: 374, Pages: 467-475, ISSN: 0140-6736
- Author Web Link
- Cite
- Citations: 100
Thayyil S, Robertson NJ, Scales A, et al., 2009, Prospective parental consent for autopsy research following sudden unexpected childhood deaths: a successful model, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 94, Pages: 354-358, ISSN: 0003-9888
- Author Web Link
- Cite
- Citations: 22
Thayyil S, Costello A, Shankaran S, et al., 2009, Therapeutic Hypothermia for Neonatal Encephalopathy: Implications for Neonatal Units in India, INDIAN PEDIATRICS, Vol: 46, Pages: 283-289, ISSN: 0019-6061
- Author Web Link
- Cite
- Citations: 20
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.