Imperial College London
Alternate

ProfessorSudhinThayyil

Faculty of Medicine, Department of Brain Sciences

Professor of Perinatal Neuroscience
 
 
 
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Contact

 

+44 (0)20 3313 8515s.thayyil

 
 
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Location

 

529Hammersmith HouseHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Montaldo:2020:10.1038/s41598-020-70131-w,
author = {Montaldo, P and Cunnington, A and Oliveira, V and Swamy, R and Bandya, P and Pant, S and Lally, P and Ivain, P and Mendoza, J and Atreja, G and Padmesh, V and Baburaj, M and Sebastian, M and Yasashwi, I and Kamalarathnam, C and Chandramohan, R and Mangalabharathi, S and Kumaraswami, K and Kumar, S and Benakappa, N and Manerkar, S and Mondhkar, J and Prakash, V and Sajjid, M and Seeralar, A and Jahan, I and Choudhury, Moni S and Shahidullah, M and Sujatha, R and Chandrasekaran, M and Ramji, S and Shankaran, S and Kaforou, M and Herberg, J and Thayyil, S},
doi = {10.1038/s41598-020-70131-w},
journal = {Scientific Reports},
pages = {1--7},
title = {Transcriptomic profile of adverse neurodevelopmental outcomes after neonatal encephalopathy},
url = {http://dx.doi.org/10.1038/s41598-020-70131-w},
volume = {10},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A rapid and early diagnostic test to identify the encephalopathic babies at risk of adverse outcome may accelerate the development of neuroprotectants. We examined if a whole blood transcriptomic signature measured soon after birth,predicts adverse neurodevelopmental outcomeeighteenmonths after neonatal encephalopathy.We performed next generation sequencing on whole blood ribonucleic acid obtained within sixhours of birth from the first 47encephalopathic babies recruited to the Hypothermia for Encephalopathy in Low and middle-income countries (HELIX)trial. Two infants with blood culture positive sepsis were excluded, and the data from remaining 45 were analysed. A total of 855genes were significantly differentially expressed between the good and adverse outcome groups, of which RGS1and SMC4 werethe most significant. Biological pathway analysis adjusted for gender, trial randomisation allocation (cooling therapy versus usual care) and estimated blood leukocyte proportions revealed over-representation of genes from pathways related to melatoninand polo-like kinase in babieswith adverse outcome. These preliminary data suggest that transcriptomic profiling may be a promising tool for rapid risk stratification in neonatal encephalopathy. It may provide insights into biological mechanismsand identify novel therapeutic targetsfor neuroprotection.
AU  - Montaldo,P
AU  - Cunnington,A
AU  - Oliveira,V
AU  - Swamy,R
AU  - Bandya,P
AU  - Pant,S
AU  - Lally,P
AU  - Ivain,P
AU  - Mendoza,J
AU  - Atreja,G
AU  - Padmesh,V
AU  - Baburaj,M
AU  - Sebastian,M
AU  - Yasashwi,I
AU  - Kamalarathnam,C
AU  - Chandramohan,R
AU  - Mangalabharathi,S
AU  - Kumaraswami,K
AU  - Kumar,S
AU  - Benakappa,N
AU  - Manerkar,S
AU  - Mondhkar,J
AU  - Prakash,V
AU  - Sajjid,M
AU  - Seeralar,A
AU  - Jahan,I
AU  - Choudhury,Moni S
AU  - Shahidullah,M
AU  - Sujatha,R
AU  - Chandrasekaran,M
AU  - Ramji,S
AU  - Shankaran,S
AU  - Kaforou,M
AU  - Herberg,J
AU  - Thayyil,S
DO  - 10.1038/s41598-020-70131-w
EP  - 7
PY  - 2020///
SN  - 2045-2322
SP  - 1
TI  - Transcriptomic profile of adverse neurodevelopmental outcomes after neonatal encephalopathy
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-020-70131-w
UR  - https://www.nature.com/articles/s41598-020-70131-w
UR  - http://hdl.handle.net/10044/1/81016
VL  - 10
ER  -
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