Imperial College London
Alternate

ProfessorSudhinThayyil

Faculty of Medicine, Department of Brain Sciences

Professor of Perinatal Neuroscience
 
 
 
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Contact

 

+44 (0)20 3313 8515s.thayyil

 
 
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Location

 

529Hammersmith HouseHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kumar:2021:10.1016/j.siny.2021.101244,
author = {Kumar, V and Singla, M and Thayyil, S},
doi = {10.1016/j.siny.2021.101244},
journal = {Seminars in Fetal and Neonatal Medicine},
title = {Cooling in mild encephalopathy: Costs and perils of therapeutic creep},
url = {http://dx.doi.org/10.1016/j.siny.2021.101244},
volume = {26},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Increasing confidence in therapeutic hypothermia and ambiguity of cooling guidelines has led to many clinicians extending its use to untested populations like mild encephalopathy, or even no encephalopathy. Poor quality clinical neurological examination for encephalopathy staging coupled with a fear of litigation if a baby with mild encephalopathy progress to moderate or severe encephalopathy appears to be the primary driver for this therapeutic creep. Recent data suggesting increased apoptosis with cooling uninjured brains, and lack of hypothermic neuroprotection in partial prolonged hypoxia, implies that such therapeutic creeps may cause more harm than benefit. Currently available preclinical and clinical data do not support the clinical use of therapeutic hypothermia for mild encephalopathy, although phase II clinical trials are ongoing. We recommend that until further evidence from adequately powered randomised controlled trials are available, cooling in mild encephalopathy need to be considered experimental and parental consent should be obtained before providing this therapy.
AU  - Kumar,V
AU  - Singla,M
AU  - Thayyil,S
DO  - 10.1016/j.siny.2021.101244
PY  - 2021///
SN  - 1084-2756
TI  - Cooling in mild encephalopathy: Costs and perils of therapeutic creep
T2  - Seminars in Fetal and Neonatal Medicine
UR  - http://dx.doi.org/10.1016/j.siny.2021.101244
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33849797
UR  - http://hdl.handle.net/10044/1/90113
VL  - 26
ER  -
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