Publications
417 results found
Khamis R, Johns M, Thom S, et al., 2012, The ASCOT Anti-oxidised LDL Antibodies Substudy, IgG Anti-malondialdehyde-ldl Antibodies are Independent Predictors of Protection From Cardiovascular Events in a Substudy of the Anglo-scandinavian Cardiac Outcomes Trial, CIRCULATION, Vol: 126, ISSN: 0009-7322
Surendran P, Vangjeli C, McCarthy N, et al., 2012, Genome-wide association analysis identifies the MTHFR-CLCN6-NPPA-NPPB gene cluster as an important influence on BNP levels-implications for the use of BNP levels in the diagnosis and therapeutic monitoring of heart failure-an ASCOT sub study, JOURNAL OF HUMAN HYPERTENSION, Vol: 26, Pages: 620-620, ISSN: 0950-9240
Kelleher E, Fulton A, Dolan E, et al., 2012, Effects of dual nitric oxide synthase and cyclooxygenase inhibition on retinal vascular responses-a novel measure of microvascular endothelial function?, JOURNAL OF HUMAN HYPERTENSION, Vol: 26, Pages: 619-620, ISSN: 0950-9240
Sever PS, Poulter NR, Chang CL, et al., 2012, Evaluation of C-reactive protein prior to and on-treatment as a predictor of benefit from atorvastatin: observations from the Anglo-Scandinavian Cardiac Outcomes Trial, EUROPEAN HEART JOURNAL, Vol: 33, Pages: 486-494, ISSN: 0195-668X
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- Citations: 44
Liu D, Wood NB, Witt N, et al., 2012, Assessment of Energy Requirement for the Retinal Arterial Network in Normal and Hypertensive Subjects, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 134, ISSN: 0148-0731
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- Citations: 4
Zhang X, Luckham PF, Hughes AD, et al., 2011, Development of lysolipid-based thermosensitive liposomes for delivery of high molecular weight proteins, INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol: 421, Pages: 291-292, ISSN: 0378-5173
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- Citations: 13
Bathula R, Hughes AD, Panerai RB, et al., 2011, South Asians have adverse cerebrovascular haemodynamics, despite equivalent blood pressure, compared with Europeans. This is due to their greater hyperglycaemia, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 40, Pages: 1490-1498, ISSN: 0300-5771
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- Citations: 15
McCarthy N, Vangjeli C, Surendran P, et al., 2011, PPARGC1β is a genetic determinant of the cardiovascular risk factor, Thromboxane A2-an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) sub-study, JOURNAL OF HUMAN HYPERTENSION, Vol: 25, Pages: 625-625, ISSN: 0950-9240
Khamis RY, Johns M, Thom S, et al., 2011, IGG ANTI-MALONEDIALDEHYDE-LDL ANTIBODIES ARE ASSOCIATED WITH LOW RISK OF CARDIOVASCULAR EVENTS IN A SUBSTUDY OF THE ANGLO-SCANDINAVIAN CARDIAC OUTCOMES TRIAL (ASCOT), AND ARE UNRELATED TO LDL, CRP LEVELS AND STATIN TREATMENT, HEART, Vol: 97, Pages: 5-5, ISSN: 1355-6037
Doughty RN, Whalley GA, Gamble GD, et al., 2011, Effects of perindopril-indapamide on left ventricular diastolic function and mass in patients with type 2 diabetes: the ADVANCE Echocardiography Substudy, JOURNAL OF HYPERTENSION, Vol: 29, Pages: 1439-1447, ISSN: 0263-6352
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- Citations: 17
Rodgers A, Patel A, Berwanger O, et al., 2011, An International Randomised Placebo-Controlled Trial of a Four-Component Combination Pill ("Polypill") in People with Raised Cardiovascular Risk, PLOS One, Vol: 6, ISSN: 1932-6203
Background: There has been widespread interest in the potential of combination cardiovascular medications containingaspirin and agents to lower blood pressure and cholesterol (‘polypills’) to reduce cardiovascular disease. However, noreliable placebo-controlled data are available on both efficacy and tolerability.Methods: We conducted a randomised, double-blind placebo-controlled trial of a polypill (containing aspirin 75 mg,lisinopril 10 mg, hydrochlorothiazide 12.5 mg and simvastatin 20 mg) in 378 individuals without an indication for anycomponent of the polypill, but who had an estimated 5-year cardiovascular disease risk over 7.5%. The primary outcomeswere systolic blood pressure (SBP), LDL-cholesterol and tolerability (proportion discontinued randomised therapy) at 12weeks follow-up.Findings: At baseline, mean BP was 134/81 mmHg and mean LDL-cholesterol was 3.7 mmol/L. Over 12 weeks, polypilltreatment reduced SBP by 9.9 (95% CI: 7.7 to 12.1) mmHg and LDL-cholesterol by 0.8 (95% CI 0.6 to 0.9) mmol/L. Thediscontinuation rates in the polypill group compared to placebo were 23% vs 18% (RR 1.33, 95% CI 0.89 to 2.00, p = 0.2).There was an excess of side effects known to the component medicines (58% vs 42%, p = 0.001), which was mostly apparentwithin a few weeks, and usually did not warrant cessation of trial treatment.Conclusions: This polypill achieved sizeable reductions in SBP and LDL-cholesterol but caused side effects in about 1 in 6people. The halving in predicted cardiovascular risk is moderately lower than previous estimates and the side effect rate ismoderately higher. Nonetheless, substantial net benefits would be expected among patients at high risk.
Starmans-Kool MJ, Stanton AV, Xu YY, et al., 2011, High dietary salt intake increases carotid blood pressure and wave reflection in normotensive healthy young men, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 110, Pages: 468-471, ISSN: 8750-7587
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- Citations: 25
Ariff BB, Glor FP, Crowe L, et al., 2010, Carotid Artery Hemodynamics: Observing Patient-specific Changes with Amlodipine and Lisinopril by Using MR Imaging Computation Fluid Dynamics, RADIOLOGY, Vol: 257, Pages: 662-669, ISSN: 0033-8419
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- Citations: 2
Davies JE, Tillin T, Malaweera A, et al., 2010, Pressure-Independent Pulsatility Index (PIPI) Independently Predicts Cardiovascular Events in the Cafe Sub-Study of Ascot, CIRCULATION, Vol: 122, ISSN: 0009-7322
Sever PS, Poulter NR, Chang C-L, et al., 2010, The Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT): Testing C-Reactive Protein at Baseline and on-Treatment as an Independent Predictor of Cardiovascular Outcomes, American-Heart-Association Scientific Sessions 2010 on Resuscitation Science Symposium, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 2219-2219, ISSN: 0009-7322
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- Citations: 1
Sofat R, Casas JP, Kumari M, et al., 2010, Genetic variation in complement factor H and risk of coronary heart disease: Eight new studies and a meta-analysis of around 48,000 individuals, ATHEROSCLEROSIS, Vol: 213, Pages: 184-190, ISSN: 0021-9150
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- Citations: 23
Bathula R, Hughes AD, Panerai R, et al., 2010, Indian Asians have poorer cardiovascular autonomic function than Europeans: this is due to greater hyperglycaemia and may contribute to their greater risk of heart disease, DIABETOLOGIA, Vol: 53, Pages: 2120-2128, ISSN: 0012-186X
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- Citations: 18
Witt NW, Chapman N, Thom SAM, et al., 2010, A novel measure to characterise optimality of diameter relationships at retinal vascular bifurcations., Artery Res, Vol: 4, Pages: 75-80, ISSN: 1872-9312
Conventionally, the relationship between parent and daughter vessels at vascular bifurcations has been expressed by the junction exponent (x), and deviations of this parameter from the optimal conditions predicted by Murray's law (x = 3) have been shown to be associated with vascular disease. However, the junction exponent is normally calculated iteratively from diameter measurements, and Monte-Carlo simulation studies show the junction exponent to be biased in the presence of measurement noise.We present an alternative parameter, referred to as optimality ratio, that is simpler to compute and also more robust in the presence of noise.To demonstrate the sensitivity of the optimality ratio to alterations in topography of the retinal vascular network, we analysed the effect of inducing endothelial dysfunction by infusion of NG-monomethyl-l-arginine (l-NMMA), a nitric oxide synthase inhibitor, compared to placebo in a double-blind crossover study. The optimality ratio showed a significant increase (p = 0.03) during infusion of l-NMMA compared to placebo.We propose that a measure of the extent of departure of optimality ratio from its optimal value of 2(-1/3) may be a useful indicator of microvascular endothelial dysfunction in vivo.
Davies JE, Lacy PS, Cruickshank K, et al., 2010, Excess pressure is higher in atenolol-treated individuals and independently predicts cardiovascular events in the CAFE substudy of ASCOT, ESC Congress, Publisher: OXFORD UNIV PRESS, Pages: 902-902, ISSN: 0195-668X
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- Citations: 2
Manisty C, Mayet J, Tapp RJ, et al., 2010, Wave Reflection Predicts Cardiovascular Events in Hypertensive Individuals Independent of Blood Pressure and Other Cardiovascular Risk Factors An ASCOT (Anglo-Scandinavian Cardiac Outcome Trial) Substudy, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 56, Pages: 24-30, ISSN: 0735-1097
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- Citations: 82
Davies J, Tillin T, Malaweera A, et al., 2010, EXCESS PRESSURE IS HIGHER IN ATENOLOL-TREATED INDIVIDUALS AND INDEPENDENTLY PREDICTS CARDIOVASCULAR EVENTS IN THE CAFE SUBSTUDY OF ASCOT, 20th Annual Meeting of the European-Society-of-Hypertension, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: E247-E247, ISSN: 0263-6352
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- Citations: 2
Dolan E, Caulfield M, Thom S, et al., 2010, AMBULATORY ARTERIAL STIFFNESS INDEX PREDICTS CARDIOVASCULAR MORBIDITY AND MORTALITY IN TREATED HYPERTENSIVE PATIENTS - AN ANGLO - SCANDINAVIAN CARDIAC OUTCOME TRIAL SUB-STUDY, 20th Annual Meeting of the European-Society-of-Hypertension, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: E13-E14, ISSN: 0263-6352
Justesen BL, Mistry P, Chaturvedi N, et al., 2010, Retinal arterioles have impaired reactivity to hyperoxia in type 1 diabetes, ACTA OPHTHALMOLOGICA, Vol: 88, Pages: 453-457, ISSN: 1755-375X
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- Citations: 17
Tapp RJ, Sharp A, Stanton AV, et al., 2010, Differential Effects of Antihypertensive Treatment on Left Ventricular Diastolic Function An ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) Substudy, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 55, Pages: 1875-1881, ISSN: 0735-1097
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- Citations: 38
Sharp ASP, Tapp RJ, Thom SAM, et al., 2010, Tissue Doppler E/E' ratio is a powerful predictor of primary cardiac events in a hypertensive population: an ASCOT substudy, EUROPEAN HEART JOURNAL, Vol: 31, Pages: 747-752, ISSN: 0195-668X
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- Citations: 155
Wimalasundera RC, Wijetunge S, Thom SM, et al., 2010, Impaired recovery of intracellular calcium and force after activation in isolated myometrial and subcutaneous resistance arteries from women with preeclampsia, JOURNAL OF HYPERTENSION, Vol: 28, Pages: 568-574, ISSN: 0263-6352
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- Citations: 3
Torii R, Keegan J, Wood NB, et al., 2010, MR image-based geometric and hemodynamic investigation of the right coronary artery withdynamic vessel motion, Annals of Biomedical Engineering, Vol: in press
The aim of this study was to develop a fully subject-specific model of the right coronaryartery (RCA), including dynamic vessel motion, for computational analysis to assess the effects ofcardiac-induced motion on hemodynamics and resulting wall shear stress (WSS). Vascular geometrieswere acquired in the right coronary artery (RCA) of a healthy volunteer using a navigator-gatedinterleaved spiral sequence at 14 time points during the cardiac cycle. A high temporal resolutionvelocity waveform was also acquired in the proximal region. Cardiac-induced dynamic vessel motionwas calculated by interpolating the geometries with an active contour model and a CFD simulationwith fully subject-specific information was carried out using this model. The results showed theexpected variation of vessel radius and curvature throughout the cardiac cycle, and also revealed thatdynamic motion of the right coronary artery consequent to cardiac motion had significant effects oninstantaneous WSS and oscillatory shear index (OSI). Subject specific MRI-based CFD is feasible and, ifscan duration could be shortened, this method may have potential as a non-invasive tool to investigatethe physiological and pathological role of hemodynamics in human coronary arteries.
Witt NC, Chapman N, Thom S, et al., 2010, A novel measure to characterise optimality of diameter relationships at retinal vascular bifurcations, Artery Research, Vol: 4, Pages: 75-80, ISSN: 1872-9312
Manisty C, Mayet J, Tapp RJ, et al., 2009, Atorvastatin Treatment Is Associated With Less Augmentation of the Carotid Pressure Waveform in Hypertension A Substudy of the Anglo- Scandinavian Cardiac Outcome Trial (ASCOT), HYPERTENSION, Vol: 54, Pages: 1009-U136, ISSN: 0194-911X
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- Citations: 38
Beulens JWJ, Patel A, Vingerling JR, et al., 2009, Effects of blood pressure lowering and intensive glucose control on the incidence and progression of retinopathy in patients with type 2 diabetes mellitus: a randomised controlled trial, DIABETOLOGIA, Vol: 52, Pages: 2027-2036, ISSN: 0012-186X
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- Citations: 129
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