Publications
417 results found
Cheung N, Wong TY, Liew G, et al., 2008, Low birth weight and retinal vascular caliber in young children, PEDIATRICS, Vol: 121, Pages: 862-863, ISSN: 0031-4005
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- Citations: 12
Tan FPP, Soloperto G, Wood NB, et al., 2008, Advanced computational models for disturbed and turbulent flow in stenosed human carotid artery bifurcation, IFMBE Proceedings, Vol: 21 IFMBE, Pages: 390-394, ISSN: 1680-0737
In this study, newly developed two-equation transitional and turbulence models are employed for the prediction of blood flow patterns in diseased carotid artery where the growth, progression and structure of plaque at rupture are closely linked to low and oscillating wall shear stresses. Moreover, laminar-turbulent transition in the post-stenotic zone can alter the separation zone length, wall shear stress and pressure distribution over the plaque, with potential implications for stresses within the plaque. A separate validation study was carried out with well established experimental measurements and numerical studies. Laminar flow, Menter's hybrid k-ε/k-ω Shear Stress Transport model and its transitional version were implemented in pulsatile simulations from which analyses of velocity profiles, wall shear stress and turbulence intensity were conducted. It was found that the transitional version of SST gave better overall agreement with experimental data for pulsatile flow in an axisymmetric stenosed tube and this is further highlighted in the patient-specific geometry simulation results. A magnetic-resonance (MR) image based model of the carotid bifurcation with 70% stenosis was reconstructed and simulated using patient-specific boundary conditions. The laminar flow assumption was found to be inadequate when the differences occurred in the wall shear stress analysis of the patient-derived model. © 2008 Springer-Verlag.
Liu D, Wood NB, Xu XY, et al., 2008, 3D reconstruction of the retinal arterial tree based on fundus images using a self-calibration approach, 1st ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing, Publisher: TAYLOR & FRANCIS LTD, Pages: 307-+
Tan FPP, Soloperto G, Wood NB, et al., 2008, Advanced Computational Models for Disturbed and Turbulent Flow in Stenosed Human Carotid Artery Bifurcation, 4th Kuala Lumpur International Conference on Biomedical Engineering, Publisher: SPRINGER, Pages: 390-+, ISSN: 1680-0737
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- Citations: 4
Byrd-Raynor S, Alastruey J, Hughes A, et al., 2008, The relationship between velocity and cerebral resistance during vasomotor reactivity testing: Should we report a different measurement?, J. Vascular Ultrasound, Vol: 32, Pages: 67-74
Tapp RJ, Williams C, Witt N, et al., 2007, Impact of size at birth on the microvasculature: The Avon Longitudinal Study of Parents and Children, PEDIATRICS, Vol: 120, Pages: E1225-E1228, ISSN: 0031-4005
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- Citations: 48
Tapp R, Sharp A, Stanton A, et al., 2007, Left ventricular diastolic function assessed by tissue Doppler echocardiography is impaired by β-blocker plus diuretic-based therapy compared with calcium, antagonist plus Ace inhibitor-based therapy:: An ASCOT substudy, 80th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 609-609, ISSN: 0009-7322
Hughes A, Manisty C, Zambanini A, et al., 2007, Lower augmentation index and wave reflection in hypertensive subjects treated with atorvastatin; An ASCOT-LLA substudy, 80th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 609-609, ISSN: 0009-7322
Alakakone A, Tillin T, Chambers J, et al., 2007, Do differences in lower limb blood flow explain the ethnic disparity in peripheral arterial disease incidence between South Asians and Europeans?, 12th Annual Meeting of the European Council for Cardiovascular Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 803-803, ISSN: 0194-911X
Malaweera ASN, Davies JE, Hadjiloizou N, et al., 2007, Pulsatile arterial pressure is predominantly determined by the aortic reservoir, which can be determined non-invasively from peripheral measurement sites, JOURNAL OF HUMAN HYPERTENSION, Vol: 21, Pages: 849-850, ISSN: 0950-9240
Dowsey AW, Keegan J, Lerotic M, et al., 2007, Motion-compensated MR valve imaging with COMB tag tracking and super-resolution enhancement., Medical Image Analysis, Vol: 11, Pages: 478-491, ISSN: 1361-8415
Understanding the morphology and function of heart valves is important to the study of underlying causes of heart failure. Existing techniques such as those based on echocardiography are limited by the relatively low signal-to-noise ratio (SNR), attenuation artefacts, and restricted access. The alternative of cardiovascular MR imaging offers versatility and accuracy in 3D localisation, but is hampered by large movements of the valves throughout the cardiac cycle. This paper presents a motion-compensated adaptive imaging approach for MR valve imaging. To illustrate its clinical potential, 3D motion of the aortic valve plane is first captured through a single breath-hold COMB tag pre-scan and then tracked in real-time with an automatic method based on multi-resolution image registration. Motion-compensated coverage of the aortic valve is then acquired prospectively, thus allowing its clear 3D reconstruction and visualisation. To provide isotropic voxel coverage of the imaging volume, retrospective projection onto convex sets (POCS) super-resolution enhancement is applied to the slice-select direction. In vivo results demonstrate the effectiveness of the proposed motion-compensation and super-resolution schemes for depicting the structure of the valve leaflets throughout the cardiac cycle. The proposed method fundamentally changes the way MR imaging is performed by transforming it from a spatially to materially localised imaging method. This also has important implications for quantifying blood flow and myocardial perfusion, as well as tracking anatomy and function of the heart.
Dotsenko O, Chaturvedi N, Thom SAM, et al., 2007, Platelet and leukocyte activation, atherosclerosis and inflammation in European and South Asian men, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol: 5, Pages: 2036-2042, ISSN: 1538-7933
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- Citations: 24
Joshi M, Tillin T, Malik I, et al., 2007, Associations between lower limb arterial calcification and markers of coronary and peripheral arterial disease in South Asian and European men, 12th Annual Meeting of the European Council for Cardiovascular Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 819-820, ISSN: 0194-911X
Sun N, Wood NB, Hughes AD, et al., 2007, Influence of pulsatile flow on LDL transport in the arterial wall, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 35, Pages: 1782-1790, ISSN: 0090-6964
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- Citations: 30
Stolk RP, van Schooneveld MJ, Cruickshank K, et al., 2007, Retinal vascular lesions in patients with type 2 diabetes mellitus of Caucasian and Asian origin: baseline results from the AdRem study, DIABETOLOGIA, Vol: 50, Pages: S447-S447, ISSN: 0012-186X
Augst AD, Ariff B, Thom SAGM, et al., 2007, Analysis of complex flow and the relationship between blood pressure, wall shear stress, and intima-media thickness in the human carotid artery, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 293, Pages: H1031-H1037, ISSN: 0363-6135
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- Citations: 73
Downie SP, Firmin DN, Wood NB, et al., 2007, Role of MRI in investigating the effects of elastic compression stockings on the deformation of the superficial and deep veins in the lower leg, JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 26, Pages: 80-85, ISSN: 1053-1807
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- Citations: 20
Curtis SL, Zambanini A, Mayet J, et al., 2007, Reduced systolic wave generation and increased peripheral wave reflection in chronic heart failure, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 293, Pages: H557-H562, ISSN: 0363-6135
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- Citations: 66
Chaturvedi N, Coady E, Mayet J, et al., 2007, Indian Asian men have less peripheral arterial disease than European men for equivalent levels of coronary disease, ATHEROSCLEROSIS, Vol: 193, Pages: 204-212, ISSN: 0021-9150
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- Citations: 39
Manisty C, Davies J, Whinnett Z, et al., 2007, Differences in the magnitude rather than the timing of wave reflection can explain the ASCOT results, Annual Scientific Conference of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A80-A80, ISSN: 1355-6037
Sun N, Wood NB, Hughes AD, et al., 2007, Effects of transmural pressure and wall shear stress on LDL accumulation in the arterial wall: a numerical study using a multilayered model, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 292, Pages: H3148-H3157, ISSN: 0363-6135
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- Citations: 51
Lacy P, Cruickshank K, Thom S, et al., 2007, Diabetes accentuates the differential impact of blood pressure lowering drugs on central aortic pressure: Principal results from cafe-diabetes; The diabetic cohort within the conduit artery functional evaluation (CAFE) study, 17th European Meeting on Hypertension, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S279-S280, ISSN: 0263-6352
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- Citations: 1
Williams B, Lacy PS, Cruickshank KJ, et al., 2007, Effect of statin therapy on central aortic pressures and hemodynamics: Principal results of the lipid lowering arm of the conduit artery function evaluation study (CAFE-LLA)., 56th Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: 404A-404A, ISSN: 0735-1097
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- Citations: 1
Tillin T, Chambers J, Malik I, et al., 2007, Measurement of pulse wave velocity: site matters, JOURNAL OF HYPERTENSION, Vol: 25, Pages: 383-389, ISSN: 0263-6352
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- Citations: 65
Martinez-Perez ME, Hughes AD, Thom SA, et al., 2007, Segmentation of blood vessels from red-free and fluorescein retinal images, MEDICAL IMAGE ANALYSIS, Vol: 11, Pages: 47-61, ISSN: 1361-8415
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- Citations: 319
Martinez-Perez ME, Hughes AD, Thom SA, et al., 2007, Improvement of a retinal blood vessel segmentation method using the Insight Segmentation and Registration Toolkit (ITK)., 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society., Pages: 892-895
Hughes AD, Coady E, Raynor S, et al., 2007, Reduced endothelial progenitor cells in European and South Asian men with atherosclerosis, EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol: 37, Pages: 35-41, ISSN: 0014-2972
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- Citations: 23
Torii R, Wood NB, Hughes AD, et al., 2007, A computational study on the influence of catheter-delivered intravascular probes on blood flow in a coronary artery model, JOURNAL OF BIOMECHANICS, Vol: 40, Pages: 2501-2509, ISSN: 0021-9290
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- Citations: 20
Wood NB, Zhao SZ, Zambanini A, et al., 2006, Curvature and tortuosity of the superficial femoral artery: a possible risk factor for peripheral arterial disease, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 101, Pages: 1412-1418, ISSN: 8750-7587
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- Citations: 104
Manisty CH, Davies JE, Zambanini A, et al., 2006, Differential arterial wave reflection in ASCOT: An explanation for the results?, 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 537-537, ISSN: 0009-7322
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