Imperial College London
Alternate

ProfessorSimonThom

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 7594 1100s.thom

 
 
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Assistant

 

Mrs Yvonne Green +44 (0)20 7594 1100

 
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Location

 

330ICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

417 results found

HUGHES A, MARTIN G, GOLDBERG P, THOM S, SEVER Pet al., 1987, NO EVIDENCE FOR A DIRECT VASODILATORY EFFECT OF CELIPROLOL ON HUMAN VASCULATURE INVIVO OR INVITRO, JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, Vol: 10, Pages: 589-592, ISSN: 0160-2446

Journal article

THOM S, HUGHES A, MARTIN G, SEVER PSet al., 1987, ENDOTHELIUM-DEPENDENT RELAXATION IN ISOLATED HUMAN ARTERIES AND VEINS, CLINICAL SCIENCE, Vol: 73, Pages: 547-552, ISSN: 0143-5221

Journal article

THOM SM, HUGHES AD, GOLDBERG P, MARTIN G, SCHACHTER M, SEVER PSet al., 1987, THE ACTIONS OF CALCITONIN GENE RELATED PEPTIDE AND VASOACTIVE-INTESTINAL-PEPTIDE AS VASODILATORS IN MAN INVIVO AND INVITRO, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 24, Pages: 139-144, ISSN: 0306-5251

Journal article

THOM S, HUGHES A, MARTIN G, GOLDBERG P, SEVER Pet al., 1987, VASODILATOR PEPTIDES - CGRP AND VIP, Publisher: GEORG THIEME VERLAG KG, Pages: 251-251, ISSN: 0340-6245

Conference paper

HUGHES AD, THOM SA, WOODALL NM, REDMAN D, SEVER PSet al., 1987, DOPAMINE PRODUCES FOREARM VASODILATATION FOLLOWING ALPHA-ADRENOCEPTOR BLOCKADE BY AN ACTION ON VASCULAR DOPAMINE (DA1) RECEPTORS IN MAN, JOURNAL OF HYPERTENSION, Vol: 5, Pages: 337-340, ISSN: 0263-6352

Journal article

WEBER JN, THOM S, BARRISON I, UNWIN R, FORSTER S, JEFFRIES DJ, BOYLSTON A, PINCHING AJet al., 1987, CYTOMEGALOVIRUS COLITIS AND ESOPHAGEAL ULCERATION IN THE CONTEXT OF AIDS - CLINICAL MANIFESTATIONS AND PRELIMINARY-REPORT OF TREATMENT WITH FOSCARNET (PHOSPHONOFORMATE), GUT, Vol: 28, Pages: 482-487, ISSN: 0017-5749

Journal article

Hughes AD, Nielsen H, Thom S, Martin GN, Sever PSet al., 1987, The effect of atrial natriuretic peptide on human blood vessels, Journal of Hypertension, Vol: 5, ISSN: 0263-6352

  • Cite
  • Citations: 12
Journal article

HUGHES A, THOM S, WOODALL N, REDMAN D, SEVER Pet al., 1987, VASCULAR DOPAMINE (DA1) RECEPTORS IN THE HUMAN FOREARM, Publisher: MARCEL DEKKER INC, Pages: 1087-1088, ISSN: 0730-0077

Conference paper

THOM S, HUGHES A, MARTIN G, REDMAN D, GOLDBERG P, SEVER Pet al., 1986, THE EFFECT OF VASODILATOR PEPTIDES INVIVO AND INVITRO IN MAN, Publisher: RAPID SCIENCE PUBLISHERS, Pages: 796-796, ISSN: 0263-6352

Conference paper

HUGHES A, THOM S, REDMAN D, SEVER Pet al., 1986, DEMONSTRATION OF VASCULAR DOPAMINE-RECEPTORS IN THE HUMAN FOREARM ARTERIAL CIRCULATION, Publisher: RAPID SCIENCE PUBLISHERS, Pages: 791-792, ISSN: 0263-6352

Conference paper

THOM S, HUGHES A, MARTIN G, REDMAN D, GOLDBERG P, SEVER Pet al., 1986, THE EFFECT OF VASODILATOR PEPTIDES INVIVO AND INVITRO IN MAN, JOURNAL OF HYPERTENSION, Vol: 4, Pages: S626-S628, ISSN: 0263-6352

Journal article

HUGHES A, THOM S, MARTIN G, REDMAN D, HASAN S, SEVER Pet al., 1986, THE ACTION OF A DOPAMINE (DA1) RECEPTOR AGONIST, FENOLDOPAM IN HUMAN VASCULATURE INVIVO AND INVITRO, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 22, Pages: 535-540, ISSN: 0306-5251

Journal article

BECKET AJ, EACOTT DW, GOLDBERG PL, SEVER PS, THOM Set al., 1986, A VACUUM CHAMBER FOR THE APPLICATION OF LOWER-BODY NEGATIVE-PRESSURE TO HUMAN-SUBJECTS, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 374, Pages: P10-P10, ISSN: 0022-3751

Journal article

HUGHES A, REDMAN D, SEVER P, THOM Set al., 1986, DOPAMINE-INDUCED VASODILATATION IN THE HUMAN FOREARM IS NOT MEDIATED BY BETA-ADRENOCEPTORS, Publisher: CAMBRIDGE UNIV PRESS, Pages: P27-P27, ISSN: 0022-3751

Conference paper

SEVER P, HUGHES A, MARTIN G, THOM Set al., 1986, CALCITONIN GENE-RELATED PEPTIDE - INVITRO ENDOTHELIUM-DEPENDENT DILATATION OF HUMAN ARTERIES AND INVIVO VASODILATATION IN THE FOREARM VASCULAR BED, Publisher: KARGER, Pages: 99-99, ISSN: 0303-6847

Conference paper

THOM S, HUGHES A, MARTIN G, SEVER Pet al., 1986, INVITRO PHARMACOLOGICAL RESPONSES OF HUMAN CORONARY-ARTERIES, Publisher: KARGER, Pages: 102-102, ISSN: 0303-6847

Conference paper

HUGHES A, THOM S, MARTIN G, SEVER Pet al., 1986, ENDOTHELIAL DEPENDENT RELAXATION OF HUMAN ARTERIES BY PEPTIDE-HORMONES, Publisher: PORTLAND PRESS LTD, Pages: P88-P89, ISSN: 0143-5221

Conference paper

HUGHES A, THOM S, REDMAN D, SEVER Pet al., 1986, FENOLDOPAM, A DOPAMINE AGONIST, INDUCES FOREARM VASODILATATION BY A MECHANISM INDEPENDENT OF SYMPATHETIC ACTIVITY, Publisher: KARGER, Pages: 77-77, ISSN: 0303-6847

Conference paper

Redman D, Thom SA, Hughes AD, Hasan S, Sever PSet al., 1985, Human vasodilator responses to a dopamine agonist: Possible mechanisms, Journal of Hypertension, Vol: 3, ISSN: 0263-6352

The action of fenoldopam, a selective dopamine DA1 agonist, on resting forearm blood flow was studied in healthy male volunteers by venous plethysmography. Metoclopramide and (±) sulpiride were used as dopamine antagonists. Intra-arterial fenoldopam over the range (100 ng/min to 1 μg/min) produced a dose-related increase in forearm blood flow without evidence of systemic effects. The response to fenoldpam was not antagonized by metoclopramide or (±) sulpiride and neither antagonist alone altered resting forearm blood flow. It is unclear whether the effects of fenoldpam in the forearm vasculature are mediated through the vascular dopamine receptor.

Journal article

HUGHES A, MARTIN G, THOM S, SEVER Pet al., 1985, DOPAMINERGIC MECHANISMS IN HUMAN PERIPHERAL VASCULATURE, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 664-665, ISSN: 0263-6352

Conference paper

THOM SA, HUGHES AD, MARTIN GN, SEVER PSet al., 1985, THE RELEASE OF THE ENDOTHELIUM DERIVED RELAXING FACTOR FROM ISOLATED HUMAN ARTERIES, JOURNAL OF HYPERTENSION, Vol: 3, Pages: S97-S99, ISSN: 0263-6352

Journal article

REDMAN D, THOM SA, HUGHES AD, HASAN S, SEVER PSet al., 1985, HUMAN VASODILATOR RESPONSES TO A DOPAMINE AGONIST - POSSIBLE MECHANISMS, JOURNAL OF HYPERTENSION, Vol: 3, Pages: S177-S178, ISSN: 0263-6352

Journal article

THOM S, CALVETE J, HAYES R, MARTIN G, SEVER Pet al., 1985, HUMAN VASCULAR SMOOTH-MUSCLE RESPONSES MEDIATED BY ALPHA-2-MECHANISMS INVIVO AND INVITRO, CLINICAL SCIENCE, Vol: 68, Pages: S147-S150, ISSN: 0143-5221

Journal article

WARREN JB, WEBER J, THOM S, KEAL EE, PINCHING AJet al., 1985, MANAGEMENT OF PULMONARY-DISEASE IN THE ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS), Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: 703-704, ISSN: 0040-6376

Conference paper

THOM S, HAYES R, CALVETE J, SEVER PSet al., 1985, INVIVO AND INVITRO STUDIES OF ALPHA-2ADRENOCEPTOR RESPONSES IN HUMAN VASCULAR SMOOTH-MUSCLE, JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, Vol: 7, Pages: S137-S143, ISSN: 0160-2446

Journal article

Thom S, Hayes R, Calvete J, Sever PSet al., 1985, In vivo and in vitro studies of alpha 2-adrenoceptor responses in human vascular smooth muscle., J Cardiovasc Pharmacol, Vol: 7 Suppl 6, Pages: S137-S143, ISSN: 0160-2446

To assess the role of alpha 2-receptor mechanisms in the control of vascular tone in humans, the pharmacological activities of RX 781094, an alpha 2-antagonist, and UK 14304, an alpha 2-agonist, have been investigated with the additional use of an alpha 1-antagonist, doxazosin. The effects of these agents on human forearm blood flow have been studied. In addition, some preliminary observations on the effects of these alpha 2-selective agents on isolated human arterial segments have been made. The alpha 2 agonist, UK 14304, produced a dose-dependent reduction in forearm blood flow, but the antagonism of this response by both doxazosin and RX 781094 at a dose which must be regarded as nonselective casts doubt on the hypothesis that alpha 2-receptors may be located postsynaptically in human vascular smooth muscle. These observations may be explained by UK 14304 having partial alpha 1-agonist activity. RX 781094 infused at low doses produced a dose-dependent reduction in forearm blood flow, which is interpreted as evidence for a presynaptic alpha 2 autoregulatory mechanism in the vasculature. Observations on isolated arterial segments (mesenteric, renal, splenic, gastric, and brachial) obtained during surgical procedures and mounted under tension in tissue baths did not provide evidence for a postsynaptic alpha 2-receptor mediating vasoconstriction. In contrast, the potentiation of the adrenaline response in the presence of the alpha 2 antagonist, RX 781094, supports the possibility that, in humans, an extrajunctional alpha 2-receptor may serve as the adrenergic mechanism for the release of an endothelial derived relaxing factor.

Journal article

Cunningham SL, Zambanini A, Mayet J, Foale RA, Parker KH, Thom SAM, Hughes ADet al., Wave intensity analysis: a novel non-invasive method for assessing haemodynamics in heart failure, EUROPEAN HEART JOURNAL, Vol: 21, Pages: 406-406, ISSN: 0195-668X

Journal article

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