Publications
417 results found
Manisty CH, Zambanini A, Parker KH, et al., 2009, Differences in the Magnitude of Wave Reflection Account for Differential Effects of Amlodipine- Versus Atenolol-Based Regimens on Central Blood Pressure An Anglo-Scandinavian Cardiac Outcome Trial Substudy, HYPERTENSION, Vol: 54, Pages: 724-U73, ISSN: 0194-911X
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- Citations: 66
Mahal S, Strain WD, Elena Martinez-Perez M, et al., 2009, Comparison of the retinal microvasculature in European and African-Caribbean people with diabetes, CLINICAL SCIENCE, Vol: 117, Pages: 229-236, ISSN: 0143-5221
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- Citations: 11
Thom S, Stettler C, Stanton A, et al., 2009, Differential Effects of Antihypertensive Treatment on the Retinal Microcirculation An Anglo-Scandinavian Cardiac Outcomes Trial Substudy, HYPERTENSION, Vol: 54, Pages: 405-408, ISSN: 0194-911X
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- Citations: 44
Stettler C, Witt N, Tapp RJ, et al., 2009, Serum Amyloid A, C-Reactive Protein, and Retinal Microvascular Changes in Hypertensive Diabetic and Nondiabetic Individuals An Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy, Diabetes Care, Vol: 32, Pages: 1098-1100, ISSN: 1935-5548
OBJECTIVE — To study the association of the inflammatory markers serum amyloid A (SAA)and C-reactive protein (CRP) with retinal microvascular parameters in hypertensive individualswith and without type 2 diabetes.RESEARCH DESIGN AND METHODS — This cross-sectional analysis was a substudyin 711 patients (159 with and 552 without diabetes) of the Anglo-Scandinavian Cardiac OutcomesTrial (ASCOT) based on digital 30-degree images of superior and inferior temporal retinalfields.RESULTS — SAA was associated with arteriolar length-to-diameter ratio positively in nondiabeticpatients (Ptrend 0.028) but negatively in diabetic patients (Ptrend 0.005). The differencewas unlikely to be a chance finding (P 0.007 for interaction). Similar results were foundfor the association of SAA with arteriolar tortuosity (P 0.05 for interaction). Associations wereless pronounced for CRP and retinal parameters.CONCLUSIONS — Inflammatory processes are differentially involved in retinal microvasculardisease in diabetic compared with nondiabetic hypertensive individuals.
Dolan E, Stanton AV, Thom S, et al., 2009, Ambulatory blood pressure monitoring predicts cardiovascular events in treated hypertensive patients - an Anglo-Scandinavian cardiac outcomes trial substudy, JOURNAL OF HYPERTENSION, Vol: 27, Pages: 876-885, ISSN: 0263-6352
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- Citations: 106
Torii R, Wood NB, Hadjiloizou N, et al., 2009, Stress phase angle depicts differences in coronary artery hemodynamics due to changes in flow and geometry after percutaneous coronary intervention, American Journal of Physiology - Heart and Circulatory Physiology, Vol: 296, Pages: H765-H776, ISSN: 0363-6135
Torii R, Wood NB, Hadjiloizou N, Dowsey AW, Wright AR, Hughes AD, Davies J, Francis DP, Mayet J, Yang G, Thom SA, Xu XY. Stress phase angle depicts differences in coronary artery hemodynamics due to changes in flow and geometry after percutaneous coronary intervention. Am J Physiol Heart Circ Physiol 296: H765-H776, 2009. First published January 16, 2009; doi:10.1152/ajpheart.01166.2007.-The effects of changes in flow velocity waveform and arterial geometry before and after percutaneous coronary intervention (PCI) in the right coronary artery (RCA) were investigated using computational fluid dynamics. An RCA from a patient with a stenosis was reconstructed based on multislice computerized tomography images. A nonstenosed model, simulating the same RCA after PCI, was also constructed. The blood flows in the RCA models were simulated using pulsatile flow waveforms acquired with an intravascular ultrasound-Doppler probe in the RCA of a patient undergoing PCI. It was found that differences in the waveforms before and after PCI did not affect the time-averaged wall shear stress and oscillatory shear index, but the phase angle between pressure and wall shear stress on the endothelium, stress phase angle (SPA), differed markedly. The median SPA was -63.9 degrees (range, -204 degrees to -10.0 degrees) for the pre-PCI state, whereas it was 10.4 degrees (range, -71.1 degrees to 25.4 degrees) in the post-PCI state, i.e., more asynchronous in the pre-PCI state. SPA has been reported to influence the secretion of vasoactive molecules (e. g., nitric oxide, PGI(2), and endothelin-1), and asynchronous SPA (approximate to -180 degrees) is proposed to be proatherogenic. Our results suggest that differences in the pulsatile flow waveform may have an important influence on atherogenesis, although associated with only minor changes in the time-averaged wall shear stress and oscillatory shear index. SPA may be a useful indicator in predicting sites prone to atherosclerosis.
Sun N, Torii R, Wood NB, et al., 2009, Computational Modeling of LDL and Albumin Transport in an In Vivo CT Image-Based Human Right Coronary Artery, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 131, ISSN: 0148-0731
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- Citations: 32
Diller G-P, Wasan BS, Thom SAM, et al., 2009, Evidence of Improved Regional Myocardial Function in Patients With Chronic Stable Angina and Apparent Normal Ventricular Function-A Tissue Doppler Study Before and After Percutaneous Coronary Intervention, JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, Vol: 22, Pages: 177-182, ISSN: 0894-7317
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- Citations: 14
Williams B, Lacy PS, Cruickshank JK, et al., 2009, Impact of Statin Therapy on Central Aortic Pressures and Hemodynamics Principal Results of the Conduit Artery Function Evaluation-Lipid-Lowering Arm (CAFE-LLA) Study, CIRCULATION, Vol: 119, Pages: 53-U98, ISSN: 0009-7322
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- Citations: 86
Torii R, Keegan J, Wood NB, et al., 2009, The effect of dynamic vessel motion on haemodynamic parameters in the right coronary artery: a combined MR and CFD study, BRITISH JOURNAL OF RADIOLOGY, Vol: 82, Pages: S24-S32, ISSN: 0007-1285
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- Citations: 25
Sun N, Leung JH, Wood NB, et al., 2009, Computational analysis of oxygen transport in a patient-specific model of abdominal aortic aneurysm with intraluminal thrombus, BRITISH JOURNAL OF RADIOLOGY, Vol: 82, Pages: S18-S23, ISSN: 0007-1285
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- Citations: 21
Tan FPP, Torii R, Borghi A, et al., 2009, Analysis of flow patterns in a patient-specific thoracic aortic aneurysm model, Publisher: Elsevier, Pages: 680-690
In this study, a newly developed two-equation transitional model was employed for the prediction of blood flow patterns in a thoracic aortic aneurysm (TAA) where the growth and progression are closely linked to low and oscillating wall shear stresses. Laminar–turbulent transition in the dilated vessel can alter the flow structure, shear stress and pressure distribution within the aneurysm. A patient-specific TAA model was reconstructed from magnetic-resonance (MR) images and measured velocity waveform was used as the inflow condition. Laminar flow and a correlation-based transitional version of Menter’s hybrid k /k x Shear Stress Transport (SST Tran) model were implemented in pulsatile simulations from which WSS distribution was obtained throughout a cardiac cycle and velocity profiles were compared with MR measurements. The correlation-based transitional model was found to produce results in closer agreement with the MR data than the laminar flow simulation.
Liu D, Wood NB, Witt N, et al., 2009, Computational Analysis of Oxygen Transport in the Retinal Arterial Network, CURRENT EYE RESEARCH, Vol: 34, Pages: 945-956, ISSN: 0271-3683
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- Citations: 36
Liu D, Wood NB, Xu XY, et al., 2009, Image-based Blood Flow Simulation in the Retinal Circulation, 4th European Conference of the International Federation for Medical and Biological Engineering (ECIFMBE), Publisher: SPRINGER, Pages: 1963-1966, ISSN: 1680-0737
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- Citations: 1
Hughes AD, Wong TY, Witt N, et al., 2009, Determinants of Retinal Microvascular Architecture in Normal Subjects, MICROCIRCULATION, Vol: 16, Pages: 159-166, ISSN: 1073-9688
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- Citations: 46
Liu D, Wood NB, Xu XY, et al., 2009, 3D Reconstruction of the Retinal Arterial Tree Using Subject-Specific Fundus Images, 1st ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing, Publisher: SPRINGER, Pages: 187-+
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- Citations: 6
Tan FPP, Soloperto G, Bashford S, et al., 2008, Analysis of Flow Disturbance in a Stenosed Carotid Artery Bifurcation Using Two-Equation Transitional and Turbulence Models, Journal of Biomechanical Engineering, Vol: 130, Pages: 061008-1-061-008-12
In this study, newly developed two-equation turbulence models and transitional variants are employed for the prediction of blood flow patterns in a diseased carotid artery where the growth, progression, and structure of the plaque at rupture are closely linked to low and oscillating wall shear stresses. Moreover, the laminar-turbulent transition in the poststenotic zone can alter the separation zone length, wall shear stress, and pressure distribution over the plaque, with potential implications for stresses within the plaque. Following the validation with well established experimental measurements and numerical studies, a magnetic-resonance (MR) image-based model of the carotid bifurcation with 70% stenosis was reconstructed and simulated using realistic patient-specific conditions. Laminar flow, a correlation-based transitional version of Menter's hybrid k-/k- shear stress transport (SST) model and its “scale adaptive simulation” (SAS) variant were implemented in pulsatile simulations from which analyses of velocity profiles, wall shear stress, and turbulence intensity were conducted. In general, the transitional version of SST and its SAS variant are shown to give a better overall agreement than their standard counterparts with experimental data for pulsatile flow in an axisymmetric stenosed tube. For the patient-specific case reported, the wall shear stress analysis showed discernable differences between the laminar flow and SST transitional models but virtually no difference between the SST transitional model and its SAS variant.
Tillin T, Dhutia H, Chambers J, et al., 2008, South Asian men have different patterns of coronary artery disease when compared with European men, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 129, Pages: 406-413, ISSN: 0167-5273
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- Citations: 36
Bathula R, Hughes AD, Thom S, et al., 2008, Mechanisms for the greater impact of diabetes on stroke risk in Indian Asians compared to Europeans, JOURNAL OF HUMAN HYPERTENSION, Vol: 22, Pages: 720-720, ISSN: 0950-9240
Bathula R, Hughes AD, Thom S, et al., 2008, Ethnic differences in sympathovagal balance and baroreceptor function are explained by dysglycaemia, 13th Annual Meeting of the European-Council-for-Cardiovascular-Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 758-758, ISSN: 0194-911X
Torii R, Wood NB, Hadjiloizou N, et al., 2008, Differences in coronary artery haemodynamics due to changes in flow and vascular geometry after percutaneous coronary intervention, 13th Annual Meeting of the European-Council-for-Cardiovascular-Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 762-762, ISSN: 0194-911X
Sharp A, Tapp R, Francis DP, et al., 2008, Ethnicity and left ventricular diastolic function in hypertension - An ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 52, Pages: 1015-1021, ISSN: 0735-1097
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- Citations: 40
Beulens JW, Vingerling JR, Cruickshank JK, et al., 2008, Effects of blood pressure lowering on incidence and progression of retinopathy in patients with type 2 diabetes mellitus: A randomised controlled trial, DIABETOLOGIA, Vol: 51, Pages: S476-S476, ISSN: 0012-186X
Stettler C, Witt N, Tapp R, et al., 2008, Retinal microvascular changes and risk of coronary heart disease in hypertensive diabetic and non-diabetic individuals: an ASCOT substudy, DIABETOLOGIA, Vol: 51, Pages: S16-S16, ISSN: 0012-186X
Stettler C, Witt N, Tapp R, et al., 2008, Retinal microvascular changes and risk of coronary heart disease in hypertensive diabetic and non-diabetic individuals: an ASCOT substudy, 44th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Pages: S16-S16
Hughes AD, Stanton AV, Jabbar AS, et al., 2008, Effect of antihypertensive treatment on retinal microvascular changes in hypertension, JOURNAL OF HYPERTENSION, Vol: 26, Pages: 1703-1707, ISSN: 0263-6352
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- Citations: 76
Torii R, Wood NB, Hadjiloizou N, et al., 2008, Differences in coronary artery haemodynamics due to changes in flow and vascular geometry after percutaneous coronary intervention, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A1-A2, ISSN: 1355-6037
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- Citations: 2
Mansity C, Zambanini A, Poulter N, et al., 2008, Atorvastatin lowers augmentation index and wave reflection in hypertensive subjects: An ASCOT-LLA substudy, 18th Scientific Meeting of the European-Society-of-Hypertension/22nd Scientific Meeting of the International-Society-of-Hypertension, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S458-S458, ISSN: 0263-6352
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- Citations: 1
Downie SP, Raynor SM, Firmin DN, et al., 2008, Effects of elastic compression stockings on wall shear stress in deep and superficial veins of the calf, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 294, Pages: H2112-H2120, ISSN: 0363-6135
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- Citations: 36
Tapp RJ, Witt N, Chaturvedi N, et al., 2008, Low birth weight and retinal vascular caliber in young children - Reply, PEDIATRICS, Vol: 121, Pages: 863-863, ISSN: 0031-4005
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