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@article{Poulter:2018:10.1161/HYPERTENSIONAHA.118.11101,
author = {Poulter, NR and Savopoulos, C and Anjum, A and Apostolopoulou, M and Chapman, N and Cross, M and Falaschetti, E and Fotiadis, S and James, RM and Kanellos, I and Szigeti, M and Thom, S and Sever, P and Thompson, D and Hatzitolios, AI},
doi = {10.1161/HYPERTENSIONAHA.118.11101},
journal = {Hypertension},
pages = {870--873},
title = {Randomized crossover trial of the impact of morning or evening dosing of antihypertensive agents on 24-hour ambulatory blood pressure: the HARMONY trial},
url = {http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11101},
volume = {72},
year = {2018}
}

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TY  - JOUR
AB  - Some data suggest that nocturnal dosing of antihypertensive agents may reduce cardiovascular outcomes more than daytime dosing. This trial was designed to evaluate whether ambulatory blood pressure monitoring levels differ by timing of drug dosing. Patients aged 18 to 80 years with reasonably controlled hypertension (≤150/≤90 mm Hg) on stable therapy of ≥1 antihypertensive agent were recruited from 2 centers in London and Thessaloniki. Patients were randomized to receive usual therapy either in the morning (6 am–11 am) or evening (6 pm–11 pm) for 12 weeks when participants crossed over to the alternative timing for a further 12 weeks. Clinic blood pressures and a 24-hour recording were taken at baseline, 12, and 24 weeks and routine blood tests were taken at baseline. The study had 80% power to detect 3 mm Hg difference in mean 24-hour systolic blood pressure (α=0.05) by time of dosing. A 2-level hierarchical regression model adjusted for center, period, and sequence was used. Of 103 recruited patients (mean age, 62; 44% female), 95 patients (92%) completed all three 24-hour recordings. Mean 24-hour systolic and diastolic blood pressures did not differ between daytime and evening dosing. Similarly, morning and evening dosing had no differential impact on mean daytime (7 am–10 pm) and nighttime (10 pm–7 am) blood pressure levels nor on clinic levels. Stratification by age (≤65/≥65 years) or sex did not affect results. In summary, among hypertensive patients with reasonably well-controlled blood pressure, the timing of antihypertensive drug administration (morning or evening) did not affect mean 24-hour or clinic blood pressure levels.
AU  - Poulter,NR
AU  - Savopoulos,C
AU  - Anjum,A
AU  - Apostolopoulou,M
AU  - Chapman,N
AU  - Cross,M
AU  - Falaschetti,E
AU  - Fotiadis,S
AU  - James,RM
AU  - Kanellos,I
AU  - Szigeti,M
AU  - Thom,S
AU  - Sever,P
AU  - Thompson,D
AU  - Hatzitolios,AI
DO  - 10.1161/HYPERTENSIONAHA.118.11101
EP  - 873
PY  - 2018///
SN  - 0194-911X
SP  - 870
TI  - Randomized crossover trial of the impact of morning or evening dosing of antihypertensive agents on 24-hour ambulatory blood pressure: the HARMONY trial
T2  - Hypertension
UR  - http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11101
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000444393600017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/63244
VL  - 72
ER  -

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