Imperial College London
Alternate

Dr Samuel Turton

Faculty of Medicine, Department of Brain Sciences

Honorary Research Associate
 
 
 
//

Contact

 

s.turton

 
 
//

Location

 

Burlington DanesHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@inproceedings{Hayes:2020:10.1016/j.euroneuro.2019.12.094,
author = {Hayes, A and Wing, V and McGonigle, J and Turton, S and Elliot, R and Ersche, KD and Flechais, R and Orban, C and Murphy, A and Smith, DG and Suckling, J and Taylor, EM and Deakin, JF and Robbins, TW and Nutt, DJ and Lingford-Hughes, AR and Paterson, LM},
doi = {10.1016/j.euroneuro.2019.12.094},
pages = {S70--S71},
publisher = {ELSEVIER},
title = {The relationship between reward processing and impulsivity in addiction: a functional magnetic resonance imaging study},
url = {http://dx.doi.org/10.1016/j.euroneuro.2019.12.094},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - Introduction: Evidence suggests that abnormalities in reward processing and increased impulsivity contribute to the pathophysiology of addiction. However, the relationship between the two is currently not well characterised. This study used fMRI to investigate the BOLD response during reward and inhibitory control tasks and how such responses were associated with subjective and behavioural measures of impulsivity in abstinent alcohol, cocaine and polydrug addiction. We hypothesized a negative correlation between non-drug related reward anticipation and impulsivity measures in polydrug and alcohol dependence compared with healthy controls owing to increased impulsivity and thus more inhibitory control effort needed to maintain successful abstinence.Methods: Abstinent alcohol dependent (AD, n=27), polydrug dependent (PD, n=57) and healthy control (HC, n=65) participants were recruited [1] (REC number 11/H0707/9). Participants completed a battery of impulsivity measures; the Barratt Impulsiveness Scale (BIS-11) and the Urgency, Premeditation, (lack of), Perseverance (lack of), Sensation Seeking, Positive Urgency, Impulsive Behaviour Scale (UPPS-P) to measure trait impulsivity, the Kirby Delay Discounting task to measure choice impulsivity and the Stop Signal Task (SST) to measure impulsive action. Participants also underwent fMRI scanning (3-T) using the monetary incentive delay (MID) and Go/No-go (GNG) tasks. An a-priori region of interest approach was used to image BOLD response during the following contrasts: reward anticipation>neutral anticipation and no-go/go in the rIFG, OFC and caudate. Data was analysed using ANOVA or Kruskal- Wallis tests (with Tukey or Mann-Whitney U post-hoc tests respectively) and Pearson's or Spearman's rank correlations, as appropriate. Holm-Bonferroni correction was applied.Results: There were significant group differences in the BIS-11 (p<0.001), UPPS-P (p<0.001) and Kirby Delay Discounting task (p=0.002). Appropriate post-hoc
AU  - Hayes,A
AU  - Wing,V
AU  - McGonigle,J
AU  - Turton,S
AU  - Elliot,R
AU  - Ersche,KD
AU  - Flechais,R
AU  - Orban,C
AU  - Murphy,A
AU  - Smith,DG
AU  - Suckling,J
AU  - Taylor,EM
AU  - Deakin,JF
AU  - Robbins,TW
AU  - Nutt,DJ
AU  - Lingford-Hughes,AR
AU  - Paterson,LM
DO  - 10.1016/j.euroneuro.2019.12.094
EP  - 71
PB  - ELSEVIER
PY  - 2020///
SN  - 0924-977X
SP  - 70
TI  - The relationship between reward processing and impulsivity in addiction: a functional magnetic resonance imaging study
UR  - http://dx.doi.org/10.1016/j.euroneuro.2019.12.094
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000509788000090&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S0924977X19318589?via%3Dihub
UR  - http://hdl.handle.net/10044/1/80751
ER  -
Download