Imperial College London
Alternate

Dr Sabita Uthaya

Faculty of Medicine, School of Public Health

Professor of Practice (Neonatal Medicine)
 
 
 
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Contact

 

+44 (0)20 3315 7975s.uthaya

 
 
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Location

 

Neonatal UnitChelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Binder:2018:10.1159/000485827,
author = {Binder, C and Longford, N and Gale, CRK and Modi, N and Uthaya, S},
doi = {10.1159/000485827},
journal = {Neonatology},
pages = {242--248},
title = {Body composition following necrotising enterocolitis in preterm infants},
url = {http://dx.doi.org/10.1159/000485827},
volume = {113},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: The optimal nutritional regimen for preterm infants, including those that develop necrotising enterocolitis (NEC), is unknown. Objective: The objective here was to evaluate body composition at term in infants following NEC, in comparison with healthy infants. The primary outcome measure was non-adipose tissue mass (non-ATM). Methods: We compared body composition assessed by magnetic resonance imaging at term in infants born <31 weeks of gestational age that participated in NEON, a trial comparing incremental versus immediate delivery of parenteral amino acids on non-ATM, and SMOF versus intralipid on intrahepatocellular lipid content. There were no differences in the primary outcomes. We compared infants that received surgery for NEC (NEC-surgical), infants with medically managed NEC (NEC-medical), and infants without NEC (reference). Results: A total of 133 infants were included (8 NEC-surgical; 15 NEC-medical; 110 reference). In comparison with the reference group, infants in the NEC-surgical and NEC-medical groups were significantly lighter [adjusted mean difference (95% CI) NEC-surgical: –630 g (–1,010, –210), p = 0.003; NEC-medical: –440 g (–760, –110), p = 0.009] and the total adipose tissue volume (ATV) was significantly lower [NEC-surgical: –360 cm3 (–516, –204), p < 0.001; NEC-medical: –127 cm3 (–251, –4); p = 0.043]. There were no significant differences in non-ATM [adjusted mean difference (95% CI) NEC-surgical: –46 g (–281, 189), p = 0.70; NEC-medical: –122 g (–308, 63), p = 0.20]. Conclusion: The lower weight at term in preterm infants following surgically and medically managed NEC, in comparison to preterm infants that did not develop the disease, was secondary to a reduction in ATV. This suggests that the nutritional regimen received was adequate to preserve non-ATM but not to support the normal third-trimester deposition of adipose tissue
AU  - Binder,C
AU  - Longford,N
AU  - Gale,CRK
AU  - Modi,N
AU  - Uthaya,S
DO  - 10.1159/000485827
EP  - 248
PY  - 2018///
SN  - 1661-7800
SP  - 242
TI  - Body composition following necrotising enterocolitis in preterm infants
T2  - Neonatology
UR  - http://dx.doi.org/10.1159/000485827
UR  - http://hdl.handle.net/10044/1/54483
VL  - 113
ER  -
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