Imperial College London
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Dr Sabine L. van Elsland

Faculty of Medicine, School of Public Health

External Relationships & Communications Manager
 
 
 
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Contact

 

+44 (0)20 7594 3896s.van-elsland

 
 
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Location

 

G35Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{van:2018:10.1111/tmi.13134,
author = {van, Elsland SL and Peters, RPH and Kok, MO and van, Toorn R and Springer, P and Cotton, MF and Grobbelaar, CJ and Aarnoutse, R and van, Furth AM},
doi = {10.1111/tmi.13134},
journal = {Trop Med Int Health},
pages = {1129--1140},
title = {A treatment-support intervention evaluated in South African paediatric populations with HIV infection or tuberculous meningitis.},
url = {http://dx.doi.org/10.1111/tmi.13134},
volume = {23},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVES: To evaluate a paediatric treatment-support intervention for home-based treatment of HIV infection or tuberculous meningitis (TBM). METHODS: A randomised-controlled study comparing local standard care (controls) with standard care plus intervention (combining adherence education, reinforcement and monitoring) in children aged 0-14 years. We recorded adherence measures (self-report, pill-count, drug-assays for isoniazid and rifampicin in urine and pyrazinamide in saliva), difficulties administering medication and PedsQL™questionnaires for health-related quality-of-life (HRQoL) and family impact. RESULTS: In the HIV group (6-months follow-up, n = 195), more children had above-median HRQoL-scores in the intervention group than in the control group (P = 0.009). Problems reported administering medication declined between baseline and follow-up for controls (P = 0.043). Disclosure of HIV status to the child increased between baseline and follow-up in both groups (intervention P < 0.001; control P = 0.031). In the TBM group (3-months follow-up, n = 43), all adherence measures remained high for both intervention and controls, except for rifampicin which declined between baseline and follow-up in the intervention group (P = 0.031). The intervention group maintained above median HRQoL-scores between baseline and follow-up, when the number of children with above-median HRQoL-scores decreased in the controls (P = 0.063). More children in the intervention group had above-median family impact-scores than controls (P = 0.040). CONCLUSIONS: The low-cost, culturally friendly treatment-support intervention had beneficial effects on health-related quality of life, family impact, caregiver disclosure of HIV status to the child, increased caregiver reporting of medication non-adherence and caregiver reporting of difficulties administering medication. Treatment adherence was not significantly affected in either HIV or TBM group.
AU  - van,Elsland SL
AU  - Peters,RPH
AU  - Kok,MO
AU  - van,Toorn R
AU  - Springer,P
AU  - Cotton,MF
AU  - Grobbelaar,CJ
AU  - Aarnoutse,R
AU  - van,Furth AM
DO  - 10.1111/tmi.13134
EP  - 1140
PY  - 2018///
SP  - 1129
TI  - A treatment-support intervention evaluated in South African paediatric populations with HIV infection or tuberculous meningitis.
T2  - Trop Med Int Health
UR  - http://dx.doi.org/10.1111/tmi.13134
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30075490
VL  - 23
ER  -
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