Imperial College London
Portrait Picture

Professor Sharon Marie Weldon

Faculty of Medicine, Department of Surgery & Cancer

Honorary Research Fellow
 
 
 
//

Contact

 

s.weldon Website

 
 
//

Location

 

H3/08Chelsea and Westminster HospitalChelsea and Westminster Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Thompson:2021:10.1136/bmjopen-2020-048298,
author = {Thompson, T and Ahmed, B and Weldon, SM and Efthimiou, O and Stubbs, B},
doi = {10.1136/bmjopen-2020-048298},
journal = {BMJ Open},
title = {Relative effectiveness of non-surgical interventions for pain management in knee osteoarthritis: a protocol for a component network meta-analysis of randomised controlled trials.},
url = {http://dx.doi.org/10.1136/bmjopen-2020-048298},
volume = {11},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: Knee osteoarthritis is a chronic degenerative disease associated with significant chronic pain, disability and impaired quality of life and is the most common form of osteoarthritis. There is no cure for knee osteoarthritis, and the main therapeutic goals are pain management and improving quality of life. The objective of this study is to evaluate the relative efficacy and acceptability of available interventions using network meta-analysis (NMA) to provide a comprehensive evidence base to inform future treatment guidelines. METHODS AND ANALYSIS: A comprehensive literature search of major electronic databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials) and clinical trial registries will identify randomised control trials (RCTs) of interventions listed in NICE guidelines for the treatment of knee osteoarthritis in adults. We will perform an NMA to estimate relative intervention effects across the whole treatment network. If any studies use multicomponent intervention packages, we will employ a component NMA model to estimate the contribution of individual components. The quality of evidence will be assessed using the Confidence in Network Meta-Analysis approach, which is based on the traditional GRADE framework adapted for NMA. Risk of bias (RoB) will be assessed using the revised Cochrane RoB 2.0 tool for RCTs. ETHICS AND DISSEMINATION: This study does not require ethical approval. Findings will be submitted to a peer-reviewed journal. PROSPERO REGISTRATION NUMBER: CRD42020184192.
AU  - Thompson,T
AU  - Ahmed,B
AU  - Weldon,SM
AU  - Efthimiou,O
AU  - Stubbs,B
DO  - 10.1136/bmjopen-2020-048298
PY  - 2021///
TI  - Relative effectiveness of non-surgical interventions for pain management in knee osteoarthritis: a protocol for a component network meta-analysis of randomised controlled trials.
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2020-048298
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34588246
VL  - 11
ER  -
Download