Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Reader in Respiratory Medicine & Pulmonary Hypertension



+44 (0)20 7351 8528s.wort




305Sydney StreetRoyal Brompton Campus





Dr S. John Wort is a HEFCE funded Clinical Senior Lecturer at the National Heart and Lung Institute, Imperial College London and Honorary Consultant at the Royal Brompton Hospital. His Clinical Specialities are Pulmonary Hypertension and Intensive Care Medicine. Dr Wort is Clinical Lead for Pulmonary Hypertension at the Royal Brompton Hospital, which is an NCG designated national centre for the treatment of pulmonary hypertension.

Dr Wort's first degree was in Chemistry, awarded from the University of Oxford (1988). He was awarded a university distinction in biochemistry and college exhibition in chemistry. He studied medicine at University College Hospitals and qualified in 1993. Dr Wort was awarded multiple pre-clinical and clinical prizes including the Meyerstein scholarship for best overall performance in BMS I and II, MacGrath prize in Medicine and John Briffa Prize for Outstanding Academic and Extra-curricular Activities. He gained his MRCP (Royal College of Physicians of London) in 1996, and was elected as a Fellow (FRCP) in 2010.

Dr Wort was awarded his PhD in 2002 which he undertook at Imperial College London, having been successfully awarded a Wellcome Trust Clinical Research Training Fellowship.  He became a Consultant in 2006, qualifying in General Medicine, Respiratory Medicine and Intensive Care Medicine (CCST).

As a Clinical Senior Lecturer, Dr Wort splits his time between developing the Pulmonary Hypertension Service, being an Intensive Care physician and continuing his research interests. These are based around understanding the pathobiology of pulmonary vascular remodelling associated with the development of pulmonary arterial hypertension (PAH). This devastating disease affects young people predominantly, causing right ventricular failure and ultimately death. In particular, he is interested in the role of inflammation on pulmonary vascular remodelling, and the interactions of bone morphogenetic protein receptor II (BMPR II) on other relevant pathways such as the endothelin-1 axis. In addition, he is Principal Investigator for a national, multi-centred, DBPC study investigating the role of an endothelin receptor antagonist, bosentan, in the treatment of pulmonary hypertension associated with interstitial lung disease (B-PHIT-1).

Dr Wort sits on the committee of the National Pulmonary Hypertension physicians group, as well as the Advisory Boards of several Pharmaceutical companies, such as Pfizer and Bayer. He is on the Editorial board of the European Respiratory Review. 

Finally, Dr Wort recently became a Fellow of The Faculty of Intensive Care Medicine.



Constantine A, Dimopoulos K, Jenkins P, et al., 2021, Use of Pulmonary Arterial Hypertension Therapies in Fontan Patients: Current Practice Across the United Kingdom, Journal of the American Heart Association, ISSN:2047-9980

Samaranayake CB, Warren C, Siewers K, et al., 2021, Impact of cyanosis on ventilatory responses during stair climb exercise in Eisenmenger syndrome and idiopathic pulmonary arterial hypertension., Int J Cardiol, Vol:341, Pages:84-87

Wustmann K, Constantine A, Davies JE, et al., 2021, Prognostic implications of pulmonary wave reflection and reservoir pressure in patients with pulmonary hypertension, International Journal of Cardiology: Congenital Heart Disease, Vol:5, ISSN:2666-6685, Pages:1-8

Wilkins M, McKie M, Law M, et al., 2021, EXPRESS: Positioning Imatinib for Pulmonary Arterial Hypertension (PIPAH): A phase I/II design comprising dose finding and single arm efficacy Short title: Imatinib for PAH, Pulmonary Circulation, Vol:11, ISSN:2045-8940, Pages:1-12

Toshner M, Church C, Harbaum L, et al., 2021, Mendelian randomisation and experimental medicine approaches to IL-6 as a drug target in PAH, European Respiratory Journal, ISSN:0903-1936

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