Publications
14 results found
Patil A, Kulkarni K, Xie S, et al., 2023, The accuracy of statistical shape models in predicting bone shape: a systematic review, International Journal of Medical Robotics and Computer Assisted Surgery, Vol: 19, Pages: 1-13, ISSN: 1478-5951
BackgroundThis systematic review aims to ascertain how accurately 3D models can be predicted from two-dimensional (2D) imaging utilising statistical shape modelling.MethodsA systematic search of published literature was conducted in September 2022. All papers which assessed the accuracy of 3D models predicted from 2D imaging utilising statistical shape models and which validated the models against the ground truth were eligible.Results2127 papers were screened and a total of 34 studies were included for final data extraction. The best overall achievable accuracy was 0.45 mm (root mean square error) and 0.16 mm (average error).ConclusionStatistical shape modelling can predict detailed 3D anatomical models from minimal 2D imaging. Future studies should report the intended application domain of the model, the level of accuracy required, the underlying demographics of subjects, and the method in which accuracy was calculated, with root mean square error recommended if appropriate.
Nolte D, Xie S, Bull A, 2023, 3D shape reconstruction of the femur from planar X-ray images using statistical shape and appearance models, BioMedical Engineering OnLine, Vol: 22, Pages: 1-14, ISSN: 1475-925X
Major trauma is a condition that can result in severe bone damage. Customised orthopaedic reconstruction allows for limb salvage surgery and helps to restore joint alignment. For the best possible outcome three dimensional (3D) medical imaging is necessary, but its availability and access, especially in developing countries, can be challenging. In this study, 3D bone shapes of the femur reconstructed from planar radiographs representing bone defects were evaluated for use in orthopaedic surgery. Statistical shape and appearance models generated from 40 cadaveric X-ray computed tomography (CT) images were used to reconstruct 3D bone shapes. The reconstruction simulated bone defects of between 0% and 50% of the whole bone, and the prediction accuracy using anterior–posterior (AP) and anterior–posterior/medial–lateral (AP/ML) X-rays were compared. As error metrics for the comparison, measures evaluating the distance between contour lines of the projections as well as a measure comparing similarities in image intensities were used. The results were evaluated using the root-mean-square distance for surface error as well as differences in commonly used anatomical measures, including bow, femoral neck, diaphyseal–condylar and version angles between reconstructed surfaces from the shape model and the intact shape reconstructed from the CT image. The reconstructions had average surface errors between 1.59 and 3.59 mm with reconstructions using the contour error metric from the AP/ML directions being the most accurate. Predictions of bow and femoral neck angles were well below the clinical threshold accuracy of 3°, diaphyseal–condylar angles were around the threshold of 3° and only version angle predictions of between 5.3° and 9.3° were above the clinical threshold, but below the range reported in clinical practice using computer navigation (i.e., 17° internal to 15° external rotation). This study shows that the reconstruc
Xie S, Wallace RJ, Pankaj P, 2020, Time-dependent behaviour of demineralised trabecular bone - Experimental investigation and development of a constitutive model, JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, Vol: 109, ISSN: 1751-6161
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- Citations: 2
Xie S, Conlisk N, Hamilton D, et al., 2020, A finite element analysis of tibial tritanium cones without stems in varying bone defects, KNEE, Vol: 27, Pages: 656-666, ISSN: 0968-0160
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- Citations: 2
Xie S, Conlisk N, Hamilton D, et al., 2020, Metaphyseal cones in revision total knee arthroplasty: The role of stems., Bone Joint Res, Vol: 9, Pages: 162-172, ISSN: 2046-3758
AIMS: Metaphyseal tritanium cones can be used to manage the tibial bone loss commonly encountered at revision total knee arthroplasty (rTKA). Tibial stems provide additional fixation and are generally used in combination with cones. The aim of this study was to examine the role of the stems in the overall stability of tibial implants when metaphyseal cones are used for rTKA. METHODS: This computational study investigates whether stems are required to augment metaphyseal cones at rTKA. Three cemented stem scenarios (no stem, 50 mm stem, and 100 mm stem) were investigated with 10 mm-deep uncontained posterior and medial tibial defects using four loading scenarios designed to mimic activities of daily living. RESULTS: Small micromotions (mean < 12 µm) were found to occur at the bone-implant interface for all loading cases with or without a stem. Stem inclusion was associated with lower micromotion, however these reductions were too small to have any clinical significance. Peak interface micromotion, even when the cone is used without a stem, was too small to effect osseointegration. The maximum difference occurred with stair descent loading. Stress concentrations in the bone occurred around the inferior aspect of each implant, with the largest occurring at the end of the long stem; these may lead to end-of-stem pain. Stem use is also found to result in stress shielding in the bone along the stem. CONCLUSION: When a metaphyseal cone is used at rTKA to manage uncontained posterior or medial defects of up to 10 mm depth, stem use may not be necessary.Cite this article: Bone Joint Res. 2020;9(4):162-172.
Xie S, Manda K, Pankaj P, 2019, Effect of loading frequency on deformations at the bone-implant interface, PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE, Vol: 233, Pages: 1219-1225, ISSN: 0954-4119
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- Citations: 3
Pankaj P, Xie S, 2019, The risk of loosening of extramedullary fracture fixation devices, INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, Vol: 50, Pages: S66-S72, ISSN: 0020-1383
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- Citations: 7
Xie S, Manda K, Pankaj P, 2018, Time-dependent behaviour of bone accentuates loosening in the fixation of fractures using bone-screw systems., Bone Joint Res, Vol: 7, Pages: 580-586, ISSN: 2046-3758
AIMS: Loosening is a well-known complication in the fixation of fractures using devices such as locking plates or unilateral fixators. It is believed that high strains in the bone at the bone-screw interface can initiate loosening, which can result in infection, and further loosening. Here, we present a new theory of loosening of implants. The time-dependent response of bone subjected to loads results in interfacial deformations in the bone which accumulate with cyclical loading and thus accentuates loosening. METHODS: We used an 'ideal' bone-screw system, in which the screw is subjected to cyclical lateral loads and trabecular bone is modelled as non-linear viscoelastic and non-linear viscoelastic-viscoplastic material, based on recent experiments, which we conducted. RESULTS: We found that the interfacial deformation in the bone increases with the number of cycles, and the use of a non-linear viscoelastic-viscoplastic model results in larger deformations, some of which are irrecoverable. There is an apparent trend in which interfacial deformations increase with increasing porosity of bone. CONCLUSION: The developed time-dependent model of the mechanical behaviour of bone permits prediction of loosening due to cyclical loads, which has not been possible previously. Application of this model shows that implant loosening will be accentuated by cyclical loading due to physiological activities, and the risks of loosening are greater in osteoporotic patients.Cite this article: S. Xie, K. Manda, P. Pankaj. Time-dependent behaviour of bone accentuates loosening in the fixation of fractures using bone-screw systems. Bone Joint Res 2018;7:580-586. DOI: 10.1302/2046-3758.710.BJR-2018-0085.R1.
Xie S, Wallace RJ, Callanan A, et al., 2018, From Tension to Compression: Asymmetric Mechanical Behaviour of Trabecular Bone's Organic Phase, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 46, Pages: 801-809, ISSN: 0090-6964
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- Citations: 4
Xie S, Manda K, Wallace RJ, et al., 2017, Time Dependent Behaviour of Trabecular Bone at Multiple Load Levels, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 45, Pages: 1219-1226, ISSN: 0090-6964
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- Citations: 19
Manda K, Wallace RJ, Xie S, et al., 2017, Nonlinear viscoelastic characterization of bovine trabecular bone (vol 16, pg 173, 2017), BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, Vol: 16, Pages: 191-195, ISSN: 1617-7959
Manda K, Wallace RJ, Xie S, et al., 2017, Nonlinear viscoelastic characterization of bovine trabecular bone, BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, Vol: 16, Pages: 173-189, ISSN: 1617-7959
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- Citations: 31
Manda K, Xie S, Wallace RJ, et al., 2016, Linear viscoelasticity - bone volume fraction relationships of bovine trabecular bone, BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, Vol: 15, Pages: 1631-1640, ISSN: 1617-7959
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- Citations: 25
Leurero-Florencio F, Margetts L, Sales E, et al., 2016, Evaluating the macroscopic yield behaviour of trabecular bone using a nonlinear homogenisation approach, JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, Vol: 61, Pages: 384-396, ISSN: 1751-6161
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- Citations: 30
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