Imperial College London


Faculty of MedicineDepartment of Infectious Disease

Honorary Clinical Research Fellow







Commonwealth BuildingHammersmith Campus





Sophie is a Consultant Physician in Infectious Diseases and General Medicine and is the Dengue Research Group Head at the Oxford University Clinical Research Unit (OUCRU), based in Ho Chi Minh City, Vietnam. She is as an Adjunct Assistant Professor at the Lee Kong Chian School of Medicine in Singapore, and holds an honorary Consultant appointment at London North West University Healthcare NHS Trust in the UK.

She was awarded a PhD in 2016, through the Imperial College Wellcome Trust Clinical PhD Programme and has a Masters degree from the London School of Hygiene and Tropical Medicine. She is a member of the Royal College of Physicians in London. She has clinical academic experience in a variety of tropical diseases, including Chagas disease, malaria and dengue, having worked in northern Australia, Kenya, Tanzania and Honduras. Her work has been supported by grants from the Wellcome Trust, NMRC Singapore, the WHO, British Heart Foundation and the Royal Society of Tropical Medicine.

She currently leads a translational programme of dengue research in OUCRU-Vietnam, including pathogenesis studies, innovative technology for monitoring critically ill patients, physiology studies of severe dengue infections as well as clinical trials of novel therapeutics.




Sangkaew S, Ming D, Boonyasiri A, et al., 2021, Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis, Lancet Infectious Diseases, ISSN:1473-3099

Vuong NL, Quyen NTH, Tien NTH, et al., 2020, Higher plasma viremia in the febrile phase is associated with adverse dengue outcomes irrespective of infecting serotype or host immune status: an analysis of 5642 Vietnamese cases., Clin Infect Dis

McBride A, Chanh HQ, Fraser JF, et al., 2020, Microvascular dysfunction in septic and dengue shock: Pathophysiology and implications for clinical management., Glob Cardiol Sci Pract, Vol:2020, ISSN:2305-7823

Zellweger RM, Yacoub S, Chan YFZ, et al., 2020, Disentangling etiologies of CNS infections in Singapore using multiple correspondence analysis and random forest, Scientific Reports, Vol:10, ISSN:2045-2322

Phung KL, McBride A, Duyen HTL, et al., 2020, Visual and Biochemical Evidence of Glycocalyx Disruption in Human Dengue Infection, and Association With Plasma Leakage Severity, Frontiers in Medicine, Vol:7

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