Publications
86 results found
Nguyen VVC, Le BC, Desquesnes M, et al., 2016, A Clinical and Epidemiological Investigation of the First Reported Human Infection With the Zoonotic Parasite Trypanosoma evansi in Southeast Asia, Clinical Infectious Diseases, Vol: 62, Pages: 1002-1008, ISSN: 1537-6591
Background. Trypanosoma is a genus of unicellular parasitic flagellate protozoa. Trypanosoma brucei species and Trypanosoma cruzi are the major agents of human trypanosomiasis; other Trypanosoma species can cause human disease, but are rare. In March 2015, a 38-year-old woman presented to a healthcare facility in southern Vietnam with fever, headache, and arthralgia. Microscopic examination of blood revealed infection with Trypanosoma.Methods. Microscopic observation, polymerase chain reaction (PCR) amplification of blood samples, and serological testing were performed to identify the infecting species. The patient's blood was screened for the trypanocidal protein apolipoprotein L1 (APOL1), and a field investigation was performed to identify the zoonotic source.Results. PCR amplification and serological testing identified the infecting species as Trypanosoma evansi. Despite relapsing 6 weeks after completing amphotericin B therapy, the patient made a complete recovery after 5 weeks of suramin. The patient was found to have 2 wild-type APOL1 alleles and a normal serum APOL1 concentration. After responsive animal sampling in the presumed location of exposure, cattle and/or buffalo were determined to be the most likely source of the infection, with 14 of 30 (47%) animal blood samples testing PCR positive for T. evansi.Conclusions. We report the first laboratory-confirmed case of T. evansi in a previously healthy individual without APOL1 deficiency, potentially contracted via a wound while butchering raw beef, and successfully treated with suramin. A linked epidemiological investigation revealed widespread and previously unidentified burden of T. evansi in local cattle, highlighting the need for surveillance of this infection in animals and the possibility of further human cases.
Yacoub S, Mongkolsapaya J, Screaton G, 2016, Recent advances in understanding dengue, F1000 Research, Vol: 5, ISSN: 2046-1402
Vannucchi V, Tomberli B, Zammarchi L, et al., 2015, Chagas disease as a cause of heart failure and ventricular arrhythmias in patients long removed from endemic areas: an emerging problem in Europe, JOURNAL OF CARDIOVASCULAR MEDICINE, Vol: 16, Pages: 817-823, ISSN: 1558-2027
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- Citations: 12
Screaton G, Mongkolsapaya J, Yacoub S, et al., 2015, New insights into the immunopathology and control of dengue virus infection, Nature Reviews Immunology, Vol: 15, Pages: 745-759, ISSN: 1474-1741
Dengue virus poses a major threat to global public health: two-thirds of the world's population is now at risk from infection by this mosquito-borne virus. Dengue virus causes a range of diseases with a small proportion of infected patients developing severe plasma leakage that leads to dengue shock syndrome, organ impairment and bleeding. Infection with one of the four viral serotypes results in the development of homotypic immunity to that serotype. However, subsequent infection with a different serotype is associated with an increased risk of developing severe disease, which has led to the suggestion that severe disease is triggered by immunopathology. This Review outlines recent advances in the understanding of immunopathology, vaccine development and human monoclonal antibodies produced against dengue virus.
Taylor WR, Fox A, Khuong TP, et al., 2015, Dengue in Adults Admitted to a Referral Hospital in Hanoi, Vietnam, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, Vol: 92, Pages: 1141-1149, ISSN: 0002-9637
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- Citations: 5
Thuy DB, Oanh KNP, Duong HTH, et al., 2015, A pregnant woman with acute cardiorespiratory failure: dengue myocarditis, LANCET, Vol: 385, Pages: 1260-1260, ISSN: 0140-6736
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- Citations: 11
Yacoub S, Wertheim H, Simmons CP, et al., 2015, Microvascular and endothelial function for risk prediction in dengue: an observational study, LANCET, Vol: 385, Pages: 102-102, ISSN: 0140-6736
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- Citations: 19
Yacoub S, Wills B, 2015, Dengue: an update for clinicians working in non-endemic areas, CLINICAL MEDICINE, Vol: 15, Pages: 82-85, ISSN: 1470-2118
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- Citations: 14
Yacoub S, Wills B, 2014, Predicting outcome from dengue, BMC MEDICINE, Vol: 12, ISSN: 1741-7015
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- Citations: 67
Whitehorn J, Yacoub S, Anders KL, et al., 2014, Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions, PLOS NEGLECTED TROPICAL DISEASES, Vol: 8, ISSN: 1935-2735
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- Citations: 48
Yacoub S, Wertheim H, Simmons CP, et al., 2014, Cardiovascular manifestations of the emerging dengue pandemic, NATURE REVIEWS CARDIOLOGY, Vol: 11, Pages: 335-345, ISSN: 1759-5002
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- Citations: 84
Yacoub S, Mongkolsapaya J, Screaton G, 2013, The pathogenesis of dengue, CURRENT OPINION IN INFECTIOUS DISEASES, Vol: 26, Pages: 284-289, ISSN: 0951-7375
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- Citations: 53
Yacoub S, Grifiths A, Chau TTH, et al., 2012, Cardiac function and haemodynamics in Vietnemese patients with different dengue severity grades, INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, Vol: 16, Pages: E119-E119, ISSN: 1201-9712
Yacoub S, Griffiths A, Tran THC, et al., 2012, Cardiac function in Vietnamese patients with different dengue severity grades, CRITICAL CARE MEDICINE, Vol: 40, Pages: 477-483, ISSN: 0090-3493
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- Citations: 46
Yacoub S, Kotit S, Yacoub MH, 2011, Disease appearance and evolution against a background of climate change and reduced resources, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, Vol: 369, Pages: 1719-1729, ISSN: 1364-503X
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- Citations: 19
Yacoub S, Lang H-J, Shebbe M, et al., 2010, Cardiac function and haemodynamics in African children with severe malaria, Critical Care Medicine, Vol: 14, Pages: E112-E113, ISSN: 1201-9712
Yacoub K, 2010, Cardiac function and hemodynamics in Kenyan children with severe malaria, Critical Care Medicine, Vol: 38, Pages: 940-945
Joshi L, Taylor SRJ, Large O, et al., 2009, A Case of Optic Neuropathy after Short-Term Linezolid Use in a Patient with Acute Lymphocytic Leukemia, CLINICAL INFECTIOUS DISEASES, Vol: 48, Pages: e73-e74, ISSN: 1058-4838
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- Citations: 26
Tan LKK, Yacoub S, Scott S, et al., 2008, Acute lung injury and other serious complications of Plasmodium vivax malaria, LANCET INFECT DIS, Vol: 8, Pages: 449-454, ISSN: 1473-3099
Plasmodium vivax infection is classified among the so-called benign malarias, but it is increasingyly recognised that serious and even life-threatening complications may occur. We present the case of a returning traveller with P vivax infection who developed acute lung injury 3 days into treatment, and discuss the serious complications of this infection. The case highlights the fact that P vivax infection is benign by name but not always by nature.
Yacoub S, Kotit S, Mocumbi AO, et al., 2008, Neglected diseases in cardiology: a call for urgent action, NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE, Vol: 5, Pages: 176-177, ISSN: 1743-4297
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- Citations: 18
Mocumbi AO, Yacoub S, Yacoub MH, 2008, Neglected tropical cardiomyopathies: II. Endomyocardial fibrosis, HEART, Vol: 94, Pages: 384-390, ISSN: 1355-6037
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- Citations: 65
Yacoub S, Mocumbi AO, Yacoub MH, 2008, Neglected tropical cardiomyopathies: I. Chagas disease, HEART, Vol: 94, Pages: 244-248, ISSN: 1355-6037
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- Citations: 28
Tan LK, Yacoub S, Scott S, et al., 2008, Acute lung injury and other serious complications of Plasmodium vivax malaria., Lancet Infectious Diseases, Vol: 8, Pages: 449-454
Yacoub S, Arellano S, Padgett-Moncada D, 2006, Violence related injuries, deaths and disabilities in the capital of Honduras, INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, Vol: 37, Pages: 428-434, ISSN: 0020-1383
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- Citations: 15
Yacoub S, Mohammed MJ, Ramsan M, et al., 2005, Clinical predictors of malaria and other febrile illnesses in children under five on Pemba Island, Tanzania, TROPICAL DOCTOR, Vol: 35, Pages: 78-81, ISSN: 0049-4755
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- Citations: 6
Yacoub S, Birks EJ, Slavik Z, et al., 2003, Early detection of myocardial dysfunction in Chagas disease using novel echocardiographic indices, TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, Vol: 97, Pages: 528-534, ISSN: 0035-9203
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- Citations: 10
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