Imperial College London
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DrSophieYacoub

Faculty of Medicine, Department of Infectious Disease

Honorary Clinical Research Fellow
 
 
 
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Contact

 

s.yacoub

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vuong:2021:10.1101/2021.03.13.21253501,
author = {Vuong, NL and Lam, PK and Ming, DKY and Duyen, HTL and Nguyen, NM and Tam, DTH and Kien, DTH and Chau, NVV and Chanpheaktra, N and Lum, LCS and Pleités, E and Simmons, CP and Rosenberger, K and Jaenisch, T and Bell, D and Acestor, N and Halleux, C and Olliaro, PL and Wills, BA and Geskus, RB and Yacoub, S},
doi = {10.1101/2021.03.13.21253501},
title = {Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes},
url = {http://dx.doi.org/10.1101/2021.03.13.21253501},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Early identification of severe dengue patients is important regarding patient management and resource allocation. We investigated the association of ten biomarkers (VCAM-1, SDC-1, Ang-2, IL-8, IP-10, IL-1RA, sCD163, sTREM-1, ferritin, CRP) with the development of severe/moderate dengue (S/MD).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We performed a nested case-control study from a multi-country study. A total of 281 S/MD and 556 uncomplicated dengue cases were included.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>On days 1-3 from symptom onset, higher levels of any biomarker increased the risk of developing S/MD. When assessing together, SDC-1 and IL-1RA were stable, while IP-10 changed the association from positive to negative; others showed weaker associations. The best combinations associated with S/MD comprised IL-1RA, Ang-2, IL-8, ferritin, IP-10, and SDC-1 for children, and SDC-1, IL-8, ferritin, sTREM-1, IL-1RA, IP-10, and sCD163 for adults.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Our findings assist the development of biomarker panels for clinical use and could improve triage and risk prediction in dengue patients.</jats:p></jats:sec><jats:sec><jats:title>Summary of the main point</jats:title><jats:p>Higher levels of any of VCAM-1, SDC-1, Ang-2, IL-8, IP-10, IL-1RA, sCD163, sTREM-1, ferritin, and CRP on illness days 1-3 increased the risk of developing severe/moderate dengue. The relationships differed between children and adults and some changed when assessed together.</jats:p></jats:sec>
AU  - Vuong,NL
AU  - Lam,PK
AU  - Ming,DKY
AU  - Duyen,HTL
AU  - Nguyen,NM
AU  - Tam,DTH
AU  - Kien,DTH
AU  - Chau,NVV
AU  - Chanpheaktra,N
AU  - Lum,LCS
AU  - Pleités,E
AU  - Simmons,CP
AU  - Rosenberger,K
AU  - Jaenisch,T
AU  - Bell,D
AU  - Acestor,N
AU  - Halleux,C
AU  - Olliaro,PL
AU  - Wills,BA
AU  - Geskus,RB
AU  - Yacoub,S
DO  - 10.1101/2021.03.13.21253501
PY  - 2021///
TI  - Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes
UR  - http://dx.doi.org/10.1101/2021.03.13.21253501
ER  -
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