Imperial College London
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DrSophieYacoub

Faculty of Medicine, Department of Infectious Disease

Honorary Clinical Research Fellow
 
 
 
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s.yacoub

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Trieu:2022:10.1186/s12916-022-02311-6,
author = {Trieu, HT and Khanh, LP and Ming, DKY and Quang, CH and Phan, TQ and Van, VCN and Deniz, E and Mulligan, J and Wills, BA and Moulton, S and Yacoub, S},
doi = {10.1186/s12916-022-02311-6},
journal = {BMC Medicine},
title = {The compensatory reserve index predicts recurrent shock in patients with severe dengue},
url = {http://dx.doi.org/10.1186/s12916-022-02311-6},
volume = {20},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Dengue shock syndrome (DSS) is one of the major clinical phenotypes of severe dengue. It is defined by significant plasma leak, leading to intravascular volume depletion and eventually cardiovascular collapse. The compensatory reserve Index (CRI) is a new physiological parameter, derived from feature analysis of the pulse arterial waveform that tracks real-time changes in central volume. We investigated the utility of CRI to predict recurrent shock in severe dengue patients admitted to the ICU. METHODS: We performed a prospective observational study in the pediatric and adult intensive care units at the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. Patients were monitored with hourly clinical parameters and vital signs, in addition to continuous recording of the arterial waveform using pulse oximetry. The waveform data was wirelessly transmitted to a laptop where it was synchronized with the patient's clinical data. RESULTS: One hundred three patients with suspected severe dengue were recruited to this study. Sixty-three patients had the minimum required dataset for analysis. Median age was 11 years (IQR 8-14 years). CRI had a negative correlation with heart rate and moderate negative association with blood pressure. CRI was found to predict recurrent shock within 12 h of being measured (OR 2.24, 95% CI 1.54-3.26), P < 0.001). The median duration from CRI measurement to the first recurrent shock was 5.4 h (IQR 2.9-6.8). A CRI cutoff of 0.4 provided the best combination of sensitivity and specificity for predicting recurrent shock (0.66 [95% CI 0.47-0.85] and 0.86 [95% CI 0.80-0.92] respectively). CONCLUSION: CRI is a useful non-invasive method for monitoring intravascular volume status in patients with severe dengue.
AU  - Trieu,HT
AU  - Khanh,LP
AU  - Ming,DKY
AU  - Quang,CH
AU  - Phan,TQ
AU  - Van,VCN
AU  - Deniz,E
AU  - Mulligan,J
AU  - Wills,BA
AU  - Moulton,S
AU  - Yacoub,S
DO  - 10.1186/s12916-022-02311-6
PY  - 2022///
SN  - 1741-7015
TI  - The compensatory reserve index predicts recurrent shock in patients with severe dengue
T2  - BMC Medicine
UR  - http://dx.doi.org/10.1186/s12916-022-02311-6
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35387649
UR  - http://hdl.handle.net/10044/1/96495
VL  - 20
ER  -
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