Imperial College London

Dr Samuel Barnes

Faculty of MedicineDepartment of Brain Sciences

Lecturer in Dementia Research & UK DRI Fellow



+44 (0)20 7594 6817samuel.barnes




Burlington DanesHammersmith Campus





My group investigates why the aged brain is vulnerable to neurodegeneration and asks whether we can alleviate this susceptibility. We focus on the role of key homeostatic neural-circuit plasticity processes thought to be critical for healthy network function.

 After graduating from Oxford University in 2006 I was awarded an MRC Capacity building Ph.D. studentship at King’s College London to investigate synaptic connection loss and neural plasticity in the cortex. I then completed a post-doc investigating how homeostatic plasticity regulates neural activity in the adult visual cortex at University College London. In October 2015, I won the Edmond J Safra Fellowship which supports early career researchers during their transition to independence. In April 2018 I was awarded a UK Dementia Research Institute Fellowship and became a lecturer in the Division of Brain Sciences at Imperial College London. Here, I use a combination of in vivo voltage and calcium imaging, bioelectronics and electrophysiology to investigate the neural-circuit plasticity factors that make the aged brain susceptible to neurodegeneration and ultimately dementia.



Radulescu CI, Barnes SJ, 2021, Learning and memory: Scaling new areas, Current Biology, Vol:31, ISSN:0960-9822, Pages:R721-R723

Davis N, Mota BC, Stead L, et al., 2021, Pharmacological ablation of astrocytes reduces Aβ degradation and synaptic connectivity in an ex vivo model of Alzheimer's disease, Journal of Neuroinflammation, Vol:18, ISSN:1742-2094

Radulescu CI, Cerar V, Haslehurst P, et al., 2021, The aging mouse brain: cognition, connectivity and calcium, Cell Calcium, Vol:94, ISSN:0143-4160, Pages:1-19

Doostdar N, Airey J, Radulescu CI, et al., 2021, Multi-scale network imaging in a mouse model of amyloidosis, Cell Calcium, ISSN:0143-4160, Pages:102365-102365

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