Imperial College London

Dr Samuel Barnes

Faculty of MedicineDepartment of Medicine

Lecturer in Dementia Research & UK DRI Fellow



+44 (0)20 7594 6817samuel.barnes




Burlington DanesHammersmith Campus





My group investigates why the aged brain is vulnerable to neurodegeneration and asks whether we can alleviate this susceptibility. We focus on the role of key homeostatic neural-circuit plasticity processes thought to be critical for healthy network function.

 After graduating from Oxford University in 2006 I was awarded an MRC Capacity building Ph.D. studentship at King’s College London to investigate synaptic connection loss and neural plasticity in the cortex. I then completed a post-doc investigating how homeostatic plasticity regulates neural activity in the adult visual cortex at University College London. In October 2015, I won the Edmond J Safra Fellowship which supports early career researchers during their transition to independence. In April 2018 I was awarded a UK Dementia Research Institute Fellowship and became a lecturer in the Division of Brain Sciences at Imperial College London. Here, I use a combination of in vivo voltage and calcium imaging, bioelectronics and electrophysiology to investigate the neural-circuit plasticity factors that make the aged brain susceptible to neurodegeneration and ultimately dementia.



Real R, Peter M, Trabalza A, et al., 2018, In vivo modeling of human neuron dynamics and Down syndrome, Science, Vol:362, ISSN:0036-8075, Pages:793-+

Barnes S, In vivo modelling of human neuron dynamics and Down syndrome, Science, ISSN:0036-8075

Sammons RP, Clopath C, Barnes SJ, 2018, Size-Dependent Axonal Bouton Dynamics following Visual Deprivation In Vivo, Cell Reports, Vol:22, ISSN:2211-1247, Pages:576-584

Barnes SJ, Franzoni E, Jacobsen RI, et al., 2017, Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss, Neuron, Vol:96, ISSN:0896-6273, Pages:871-+

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