Imperial College London

Dr Samuel Barnes

Faculty of MedicineDepartment of Brain Sciences

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 6817samuel.barnes

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Summary

My group investigates why the aged brain is vulnerable to neurodegeneration and asks whether we can alleviate this susceptibility. We focus on the role of key homeostatic neural-circuit plasticity processes thought to be critical for healthy network function.

 After graduating from Oxford University in 2006 I was awarded an MRC Capacity building Ph.D. studentship at King’s College London to investigate synaptic connection loss and neural plasticity in the cortex. I then completed a post-doc investigating how homeostatic plasticity regulates neural activity in the adult visual cortex at University College London. In October 2015, I won the Edmond J Safra Fellowship which supports early career researchers during their transition to independence. In April 2018 I was awarded a UK Dementia Research Institute Fellowship and became a lecturer in the Division of Brain Sciences at Imperial College London. Here, I use a combination of in vivo voltage and calcium imaging, bioelectronics and electrophysiology to investigate the neural-circuit plasticity factors that make the aged brain susceptible to neurodegeneration and ultimately dementia.

Publications

Journals

Melgosa-Ecenarro L, Doostdar N, Radulescu CI, et al., 2023, Pinpointing the locus of GABAergic vulnerability in Alzheimer's disease., Semin Cell Dev Biol, Vol:139, Pages:35-54

Barnes SJ, Keller GB, Keck T, 2022, Homeostatic regulation through strengthening of neuronal network-correlated synaptic inputs., Elife, Vol:11

Dehghan A, Pinto RC, Karaman I, et al., 2022, Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease., Proceedings of the National Academy of Sciences of Usa, Vol:119, ISSN:0027-8424, Pages:1-12

Morten MJ, Sirvio L, Rupawala H, et al., 2022, Quantitative super-resolution imaging of pathological aggregates reveals distinct toxicity profiles in different synucleinopathies., Proceedings of the National Academy of Sciences of Usa, Vol:119, ISSN:0027-8424, Pages:1-12

Radulescu CI, Barnes SJ, 2021, Learning and memory: Scaling new areas, Current Biology, Vol:31, ISSN:0960-9822, Pages:R721-R723

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