Imperial College London

Dr Samuel Barnes

Faculty of MedicineDepartment of Brain Sciences

Senior Lecturer



+44 (0)20 7594 6817samuel.barnes




Burlington DanesHammersmith Campus





My group investigates why the aged brain is vulnerable to neurodegeneration and asks whether we can alleviate this susceptibility. We focus on the role of key homeostatic neural-circuit plasticity processes thought to be critical for healthy network function.

 After graduating from Oxford University in 2006 I was awarded an MRC Capacity building Ph.D. studentship at King’s College London to investigate synaptic connection loss and neural plasticity in the cortex. I then completed a post-doc investigating how homeostatic plasticity regulates neural activity in the adult visual cortex at University College London. In October 2015, I won the Edmond J Safra Fellowship which supports early career researchers during their transition to independence. In April 2018 I was awarded a UK Dementia Research Institute Fellowship and became a lecturer in the Division of Brain Sciences at Imperial College London. Here, I use a combination of in vivo voltage and calcium imaging, bioelectronics and electrophysiology to investigate the neural-circuit plasticity factors that make the aged brain susceptible to neurodegeneration and ultimately dementia.



Radulescu CI, Doostdar N, Zabouri N, et al., 2023, Age-related dysregulation of homeostatic control in neuronal microcircuits, Nature Neuroscience, Vol:26, ISSN:1097-6256, Pages:2158-2170

Rueda-Carrasco J, Sokolova D, Lee S-E, et al., 2023, Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models, Embo Journal, Vol:42, ISSN:0261-4189

Nutma E, Fancy N, Weinert M, et al., 2023, Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases, Nature Communications, Vol:14, ISSN:2041-1723, Pages:1-25

Melgosa-Ecenarro L, Doostdar N, Radulescu CI, et al., 2023, Pinpointing the locus of GABAergic vulnerability in Alzheimer?s disease, Seminars in Cell & Developmental Biology, Vol:139, ISSN:1084-9521, Pages:35-54

Barnes SJ, Keller GB, Keck T, 2022, Homeostatic regulation through strengthening of neuronal network-correlated synaptic inputs, Elife, Vol:11, ISSN:2050-084X

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