My group investigates why the aged brain is vulnerable to neurodegeneration and asks whether we can alleviate this susceptibility. We focus on the role of key homeostatic neural-circuit plasticity processes thought to be critical for healthy network function.
After graduating from Oxford University in 2006 I was awarded an MRC Capacity building Ph.D. studentship at King’s College London to investigate synaptic connection loss and neural plasticity in the cortex. I then completed a post-doc investigating how homeostatic plasticity regulates neural activity in the adult visual cortex at University College London. In October 2015, I won the Edmond J Safra Fellowship which supports early career researchers during their transition to independence. In April 2018 I was awarded a UK Dementia Research Institute Fellowship and became a lecturer in the Division of Brain Sciences at Imperial College London. Here, I use a combination of in vivo voltage and calcium imaging, bioelectronics and electrophysiology to investigate the neural-circuit plasticity factors that make the aged brain susceptible to neurodegeneration and ultimately dementia.
et al., 2018, In vivo modeling of human neuron dynamics and Down syndrome, Science, Vol:362, ISSN:0036-8075, Pages:793-+
Sammons RP, Clopath C, Barnes SJ, 2018, Size-Dependent Axonal Bouton Dynamics following Visual Deprivation In Vivo, Cell Reports, Vol:22, ISSN:2211-1247, Pages:576-584
et al., 2017, Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss, Neuron, Vol:96, ISSN:0896-6273, Pages:871-+
Song C, Barnes S, Knopfel T, 2017, Mammalian cortical voltage imaging using genetically encoded voltage indicators: a review honoring professor Amiram Grinvald, Neurophotonics, Vol:4, ISSN:2329-423X