My group investigates why the aged brain is vulnerable to neurodegeneration and asks whether we can alleviate this susceptibility. We focus on the role of key homeostatic neural-circuit plasticity processes thought to be critical for healthy network function.
After graduating from Oxford University in 2006 I was awarded an MRC Capacity building Ph.D. studentship at King’s College London to investigate synaptic connection loss and neural plasticity in the cortex. I then completed a post-doc investigating how homeostatic plasticity regulates neural activity in the adult visual cortex at University College London. In October 2015, I won the Edmond J Safra Fellowship which supports early career researchers during their transition to independence. In April 2018 I was awarded a UK Dementia Research Institute Fellowship and became a lecturer in the Division of Brain Sciences at Imperial College London. Here, I use a combination of in vivo voltage and calcium imaging, bioelectronics and electrophysiology to investigate the neural-circuit plasticity factors that make the aged brain susceptible to neurodegeneration and ultimately dementia.
et al., 2023, Pinpointing the locus of GABAergic vulnerability in Alzheimer's disease., Semin Cell Dev Biol, Vol:139, Pages:35-54
Barnes SJ, Keller GB, Keck T, 2022, Homeostatic regulation through strengthening of neuronal network-correlated synaptic inputs., Elife, Vol:11
et al., 2022, Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease., Proceedings of the National Academy of Sciences of Usa, Vol:119, ISSN:0027-8424, Pages:1-12
et al., 2022, Quantitative super-resolution imaging of pathological aggregates reveals distinct toxicity profiles in different synucleinopathies., Proceedings of the National Academy of Sciences of Usa, Vol:119, ISSN:0027-8424, Pages:1-12
Radulescu CI, Barnes SJ, 2021, Learning and memory: Scaling new areas, Current Biology, Vol:31, ISSN:0960-9822, Pages:R721-R723