Imperial College London
Dr Samuel Marguerat

DrSamuelMarguerat

Faculty of Natural Sciences, Department of Mathematics

Visiting Researcher
 
 
 
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Contact

 

+44 (0)20 3313 8331samuel.marguerat Website

 
 
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Location

 

5003CRB (Clinical Research Building)Hammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Clements:2017:10.1016/j.neuron.2017.09.008,
author = {Clements, MP and Byrne, E and Camarillo, Guerrero LF and Cattin, A-L and Zakka, L and Ashraf, A and Burden, JJ and Khadayate, S and Lloyd, AC and Marguerat, S and Parrinello, S},
doi = {10.1016/j.neuron.2017.09.008},
journal = {Neuron},
pages = {98--114.e7},
title = {The wound microenvironment reprogrammes Schwann cells to invasive mesenchymal- like cells to drive peripheral nerve regeneration},
url = {http://dx.doi.org/10.1016/j.neuron.2017.09.008},
volume = {96},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Schwann cell dedifferentiation from a myelinating to a progenitor-like cell underlies the remarkable ability of peripheral nerves to regenerate following injury. However, the molecular identity of the differentiated and dedifferentiated states in vivo has been elusive. Here, we profiled Schwann cells acutely purified from intact nerves and from the wound and distal regions of severed nerves. Our analysis reveals novel facets of the dedifferentiation response, including acquisition of mesenchymal traits and a Myc module. Furthermore, wound and distal dedifferentiated Schwann cells constitute different populations, with wound cells displaying increased mesenchymal character induced by localized TGFβ signaling. TGFβ promotes invasion and crosstalks with Eph signaling via N-cadherin to drive collective migration of the Schwann cells across the wound. Consistently, Tgfbr2 deletion in Schwann cells resulted in misdirected and delayed reinnervation. Thus, the wound microenvironment is a key determinant of Schwann cell identity, and it promotes nerve repair through integration of multiple concerted signals.
AU  - Clements,MP
AU  - Byrne,E
AU  - Camarillo,Guerrero LF
AU  - Cattin,A-L
AU  - Zakka,L
AU  - Ashraf,A
AU  - Burden,JJ
AU  - Khadayate,S
AU  - Lloyd,AC
AU  - Marguerat,S
AU  - Parrinello,S
DO  - 10.1016/j.neuron.2017.09.008
EP  - 114
PY  - 2017///
SN  - 0896-6273
SP  - 98
TI  - The wound microenvironment reprogrammes Schwann cells to invasive mesenchymal- like cells to drive peripheral nerve regeneration
T2  - Neuron
UR  - http://dx.doi.org/10.1016/j.neuron.2017.09.008
UR  - http://hdl.handle.net/10044/1/50799
VL  - 96
ER  -
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