Imperial College London
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Dr Sara Bonvini

Faculty of Medicine, National Heart & Lung Institute

Academic Visitor
 
 
 
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Contact

 

+44 (0)20 7594 8397sara.bonvini10

 
 
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Location

 

102Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Belvisi:2016:10.1164/rccm.201508-1602OC,
author = {Belvisi, MG and Birrell, MA and Khalid, S and Wortley, MA and Dockry, R and Coote, J and Holt, K and Dubuis, E and Kelsall, A and Maher, SA and Bonvini, S and Woodcock, A and Smith, JA},
doi = {10.1164/rccm.201508-1602OC},
journal = {American Journal of Respiratory and Critical Care Medicine},
pages = {1364--1372},
title = {Neurophenotypes in airway diseases: insights from translational cough studies},
url = {http://dx.doi.org/10.1164/rccm.201508-1602OC},
volume = {193},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Rationale: Most airway diseases, including chronic obstructive pulmonary disease (COPD), are associated with excessive coughing. The extent to which this may be a consequence of increased activation of vagal afferents by pathology in the airways (e.g. inflammatory mediators, excessive mucus) or an altered neuronal phenotype is unknown. Understanding whether respiratory diseases are associated with dysfunction of airway sensory nerves has the potential to identify novel therapeutic targets. Objectives: To assess the changes in cough responses to a range of inhaled irritants in COPD, and model these in animals to investigate the underlying mechanisms. Methods: Cough responses to inhaled stimuli in patients with COPD, healthy smokers, refractory chronic cough, asthma and healthy volunteers were assessed and compared with vagus/airway nerve and cough responses in a cigarette smoke (CS) exposure guinea-pig model. Measurements and Main Results: Patients with COPD had heightened cough responses to capsaicin but reduced responses to PGE2 compared with healthy volunteers. Furthermore, the different patient groups all exhibited different patterns of modulation of cough responses. Consistent with these findings, capsaicin caused a greater number of coughs in CS-exposed guinea-pigs than in controls; similar increased responses were observed in ex-vivo vagus nerve and neuron cell bodies in the vagal ganglia. However, responses to PGE2 were decreased by CS-exposure. Conclusions: CS exposure is capable of inducing responses consistent with phenotypic switching in airway sensory nerves comparable to the cough responses observed in patients with COPD. Moreover, the differing profiles of cough responses support the concept of disease-specific neuro-phenotypes in airway disease.
AU  - Belvisi,MG
AU  - Birrell,MA
AU  - Khalid,S
AU  - Wortley,MA
AU  - Dockry,R
AU  - Coote,J
AU  - Holt,K
AU  - Dubuis,E
AU  - Kelsall,A
AU  - Maher,SA
AU  - Bonvini,S
AU  - Woodcock,A
AU  - Smith,JA
DO  - 10.1164/rccm.201508-1602OC
EP  - 1372
PY  - 2016///
SN  - 1535-4970
SP  - 1364
TI  - Neurophenotypes in airway diseases: insights from translational cough studies
T2  - American Journal of Respiratory and Critical Care Medicine
UR  - http://dx.doi.org/10.1164/rccm.201508-1602OC
UR  - http://hdl.handle.net/10044/1/33588
VL  - 193
ER  -
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