Imperial College London
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Dr Sayan Sen

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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sayan.sen

 
 
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Location

 

ICCHSt Mary's Research BuildingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{de:2016:10.1161/JAHA.116.004482,
author = {de, Waard GA and Nijjer, SS and van, Lavieren MA and van, der Hoeven NW and Petraco, R and van, de Hoef TP and Echavarria-Pinto, M and Sen, S and van, de Ven PM and Knaapen, P and Escaned, J and Piek, JJ and Davies, JE and van, Royen N},
doi = {10.1161/JAHA.116.004482},
journal = {Journal of the American Heart Association},
title = {Invasive minimal Microvascular Resistance Is a New Index to Assess Microcirculatory Function Independent of Obstructive Coronary Artery Disease},
url = {http://dx.doi.org/10.1161/JAHA.116.004482},
volume = {5},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background-—Coronary microcirculatory dysfunction portends a poor cardiovascular outcome. Invasive assessment ofmicrocirculatory dysfunction by coronary flow reserve (CFR) and hyperemic microvascular resistance (HMR) is affected bycoronary artery disease (CAD). In this study we propose minimal microvascular resistance (mMR) as a new measure ofmicrocirculatory dysfunction and aim to determine whether mMR is influenced by CAD.Methods and Results-—We obtained 482 simultaneous measurements of intracoronary Doppler flow velocity and pressure. ThemMR is defined as the ratio between distal coronary pressure and flow velocity during the hyperemic wave-free period.Measurements were divided into 2 cohorts. Cohort 1 was a paired analysis involving 81 pairs with a vessel with and without CAD toinvestigate whether HMR, CFR, and mMR are modulated by CAD. CFR was lower, and HMR was higher, in vessels with CAD than invessels without CAD: 2.12 0.79 versus 2.56 0.63 mm Hgcm 1s, P<0.001, and 2.61 1.22 versus 2.31 0.89 mm Hgcm 1s,P=0.04, respectively. mMR was equal in vessels with and without CAD: 1.54 0.77 versus 1.53 0.57 mm Hgcm 1s, P=0.90.Differences for CFR occurred when FFR was 0.60 to 0.80 or ≤0.60 but not when FFR ≥0.80. For HMR, the difference occurred onlywhen FFR ≤0.60. For mMR, no difference was observed in any FFR stratum. Cohort 2 was used for validation and showed significantrelationships for CFR and HMR with FFR: Pearson r=0.488, P<0.001 and  0.159, P=0.03, respectively; mMR had no associationwith FFR: Pearson r=0.055; P=0.32.Conc
AU  - de,Waard GA
AU  - Nijjer,SS
AU  - van,Lavieren MA
AU  - van,der Hoeven NW
AU  - Petraco,R
AU  - van,de Hoef TP
AU  - Echavarria-Pinto,M
AU  - Sen,S
AU  - van,de Ven PM
AU  - Knaapen,P
AU  - Escaned,J
AU  - Piek,JJ
AU  - Davies,JE
AU  - van,Royen N
DO  - 10.1161/JAHA.116.004482
PY  - 2016///
SN  - 2047-9980
TI  - Invasive minimal Microvascular Resistance Is a New Index to Assess Microcirculatory Function Independent of Obstructive Coronary Artery Disease
T2  - Journal of the American Heart Association
UR  - http://dx.doi.org/10.1161/JAHA.116.004482
UR  - http://hdl.handle.net/10044/1/53758
VL  - 5
ER  -
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