Imperial College London

Shahid A Khan

Faculty of MedicineFaculty of Medicine Centre

Professor of Practice (Haematology)
 
 
 
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Contact

 

+44 (0)20 3312 6254shahid.khan

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

135 results found

Cross TJS, Villaneuva A, Shetty S, Wilkes E, Collins P, Adair A, Jones RL, Foxton MR, Meyer T, Stern N, Warshow U, Khan N, Prince M, Khakoo S, Alexander GJ, Khan S, Reeves H, Marshall A, Williams Ret al., 2016, A national survey of the provision of ultrasound surveillance for the detection of hepatocellular carcinoma, Frontline Gastroenterology, Vol: 7, Pages: 82-89, ISSN: 2041-4137

Objective: Hepatocellular carcinoma (HCC), the sixth most common cancer worldwide and third most common cause of cancer related death, is closely associated with the presence of cirrhosis. Survival is determined by the stage of the cancer, with asymptomatic small tumours being more amenable to treatment. Early diagnosis is dependent on regular surveillance and the primary objective of this survey was to gain a better understanding of the baseline attitudes towards and provision of ultrasound surveillance (USS) HCC surveillance in the UK. In addition, information was obtained on the stages of cancer of the patients being referred to and discussed at regional multidisciplinary team meetings. Design: UK hepatologists, gastroenterologists and nurse specialists were sent a questionnaire survey regarding the provision of USS for detection of HCC in their respective hospitals. Results: Provision of surveillance was poor overall, with many hospitals lacking the necessary mechanisms to make abnormal results, if detected, known to referring clinicians. There was also a lack of standard data collection and in many hospitals basic information on the number of patients with cirrhosis and how many were developing HCC was not known. For the majority of new HCC cases was currently being made only at an incurable late stage (60%). Conclusions In the UK, the current provision of USS based HCC surveillance is poor and needs to be upgraded urgently.

Journal article

Howell JA, Khan SA, 2016, The role of miRNAs in cholangiocarcinoma, HEPATIC ONCOLOGY, Vol: 3, Pages: 167-180, ISSN: 2045-0923

Journal article

Shariff MIF, Tognarelli JM, Lewis MR, Want EJ, Mohamed FEZ, Ladep NG, Crossey MME, Khan SA, Jalan R, Holmes E, Taylor-Robinson SDet al., 2015, Plasma Lipid Profiling in a Rat Model of Hepatocellular Carcinoma: Potential Modulation Through Quinolone Administration, JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY, Vol: 5, Pages: 286-294, ISSN: 0973-6883

Journal article

Nooredinvand HA, Connell DW, Asgheddi M, Abdullah M, O'Donoghue M, Campbell L, Wickremasinghe MI, Lalvani A, Kon OM, Khan SAet al., 2015, Viral hepatitis prevalence in patients with active and latent tuberculosis, World Journal of Gastroenterology, Vol: 21, Pages: 8920-8926, ISSN: 1007-9327

AIM: To assess the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and association with drug induced liver injury (DILI) in patients undergoing anti-tuberculosis (TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB - either active disease or latent infection - who were due to commence anti-TB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus (HIV) infections - hepatitis B core antigen (HBcAg), hepatitis B surface antigen (HBsAg), hepatitis B e antigen, IgG and IgM antibody to HBcAg (anti-HBc), HCV IgG antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of anti-TB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher’s exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270 (62.9%) had active TB disease and 159 (37.1%) had latent TB infection. 61 (14.2%) patients had isolated anti-HBc positivity, 11 (2.6%) were also HBsAg positive and 7 (1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis (HBsAg or HCV antibody positive; P = 0.023). Similarly the proportion of HBsAg positive patients were significantly greater in the active vs latent TB infection group (10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each

Journal article

Khan SA, 2015, The changing etiology of liver cancer, HEPATIC ONCOLOGY, Vol: 2, Pages: 221-223, ISSN: 2045-0923

Journal article

Taylor-Robinson SD, Wong J, Crossey MME, Khan SAet al., 2015, Evidence is weak to support hepatocellular carcinoma screening in chronic liver disease., Evid Based Med, Vol: 20

Journal article

Chapman R, Lin Y, Burnapp M, Bentham A, Hillier D, Zabron A, Khan S, Tyreman M, Stevens MMet al., 2015, Multivalent nanoparticle networks enable point-of-care detection of human phospholipase-A2 in serum, ACS Nano, Vol: 9, Pages: 2565-2573, ISSN: 1936-086X

Journal article

Ladep NG, Dona AC, Lewis MR, Crossey MME, Lemoine M, Okeke E, Shimakawa Y, Duguru M, Njai HF, Fye HKS, Taal M, Chetwood J, Kasstan B, Khan SA, Garside DA, Wijeyesekera A, Thillainayagam AV, Banwat E, Thursz MR, Nicholson JK, Njie R, Holmes E, Taylor-Robinson SDet al., 2014, Discovery and Validation of Urinary Metabotypes for the Diagnosis of Hepatocellular Carcinoma in West Africans, HEPATOLOGY, Vol: 60, Pages: 1291-1301, ISSN: 0270-9139

Journal article

Mukherjee S, Khan SA, Toledano MB, Bilton D, Simmonds NJet al., 2014, THE BURDEN OF CYSTIC FIBROSIS ASSOCIATED LIVER DISEASE IN THE UNITED KINGDOM: A NATIONAL REGISTRY REVIEW, 2008-2012, PEDIATRIC PULMONOLOGY, Vol: 49, Pages: 414-415, ISSN: 8755-6863

Journal article

Bridgewater J, Galle PR, Khan SA, Llovet JM, Park J-W, Patel T, Pawlik TM, Gores GJet al., 2014, Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma, JOURNAL OF HEPATOLOGY, Vol: 60, Pages: 1268-1289, ISSN: 0168-8278

Journal article

Ladep NG, Lewis M, Gomez-Romero M, Lemoine M, Okeke E, Njie R, Banwat E, Fye H, Khan SA, Garside D, Crossey M, Fiyaktu Y, Mary D, Thursz M, Holmes E, Taylor-Robinson SDet al., 2014, BIOMARKER DISCOVERY USING ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY QUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETRY IDENTIFIES DIAGNOSTIC URINARY METABOLIC PANELS FOR HCC IN AFRICANS, 49th Annual International Liver Congress of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S256-S256, ISSN: 0168-8278

Conference paper

Vergis N, Khamri W, Atkinson S, Tidswell R, Gill U, Ryan J, Bernsmeier C, Triantafyllou E, Blackmore L, Moore C, Marcinkowski H, Possamai L, Mullish BH, Khan S, Dhar A, Foxton M, Shawcross D, Ma Y, Antoniades CG, Thursz MRet al., 2014, Monocyte oxidative burst defect predicts risk of infection in alcoholic hepatitis, International Liver Conference 2014/ 49th Annual Meeting of the European Association for the Study of the Liver, Publisher: Elsevier Science BV, Pages: S168-S168, ISSN: 0168-8278

Conference paper

Ladep NG, Khan SA, Crossey MME, Thillainayagam AV, Taylor-Robinson SD, Toledano MBet al., 2014, Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations, WORLD JOURNAL OF GASTROENTEROLOGY, Vol: 20, Pages: 1544-1553, ISSN: 1007-9327

Journal article

Dixon PH, Wadsworth CA, Chambers J, Donnelly J, Cooley S, Buckley R, Mannino R, Jarvis S, Syngelaki A, Geenes V, Paul P, Sothinathan M, Kubitz R, Lammert F, Tribe RM, Ch'ng CL, Marschall H-U, Glantz A, Khan SA, Nicolaides K, Whittaker J, Geary M, Williamson Cet al., 2014, A Comprehensive Analysis of Common Genetic Variation Around Six Candidate Loci for Intrahepatic Cholestasis of Pregnancy, AMERICAN JOURNAL OF GASTROENTEROLOGY, Vol: 109, Pages: 76-84, ISSN: 0002-9270

Journal article

Khan SA, 2014, Interview: Challenges and prospects for liver cancer management: treatment, prevention and collaboration., Hepat Oncol, Vol: 1, Pages: 17-21

Dr Shahid Khan qualified in Medicine at Guys Hospital Medical School (London, UK) in 1994. His studies in liver cancer led to a PhD from the University of London in 2003 and he was appointed Consultant in Gastroenterology and Hepatology at St Mary's and Hammersmith Hospitals, Imperial College London Healthcare NHS Trust; and a Clinical Senior Lecturer at Imperial College London in 2007. Dr Khan has lectured on liver disease nationally and internationally at hepatology and gastroenterology conferences, including state-of-the-art and invited presentations. He is the lead author on the UK National Guidelines for biliary cancer and was on the International Liver Cancer Association panel for the International Guidelines. He has published extensively in the medical literature, including original research articles, reviews and book chapters. Dr Khan is a Fellow of the Royal College of Physicians of the UK, and a member of the British Medical Association, the British Association for the Study of the Liver, the British Society of Gastroenterology, the European Association for the Study of the Liver, the American Association for the Study of the Liver Diseases and the International Liver Cancer Association.

Journal article

Crawford-Smith H, Mullish BH, McPhail MJW, Marcinkowski H, Lloyd J, Goldin R, Khan SAet al., 2013, An Investigation of the Correlation Between Transient Elastography using FibroScan™ and Liver Biopsy in the Assessment of Liver Fibrosis., BASL Annual Meeting 2013

Conference paper

Wadsworth CA, Lim A, Taylor-Robinson SD, Khan SAet al., 2013, The risk factors and diagnosis of cholangiocarcinoma, HEPATOLOGY INTERNATIONAL, Vol: 7, Pages: 377-393, ISSN: 1936-0533

Journal article

Shariff MIF, Khan SA, Westaby D, 2013, The palliation of cholangiocarcinoma, CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE, Vol: 7, Pages: 168-174, ISSN: 1751-4258

Journal article

Wadsworth CA, Horneffer-van der Sluis VM, Zabron A, Taylor-Robinson SD, Edwards RJ, Khan SAet al., 2013, DISCOVERY OF POTENTIAL PLASMA BIOMARKERS OF CHOLANGIOCARCINOMA UTILISING SURFACE-ENHANCED LASER DESORPTION/IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY (SELDI-TOF MS), Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: BMJ PUBLISHING GROUP, Pages: A86-A86, ISSN: 0017-5749

Conference paper

Wadsworth CA, Westaby D, Khan SA, 2013, Endoscopic radiofrequency ablation for cholangiocarcinoma, CURRENT OPINION IN GASTROENTEROLOGY, Vol: 29, Pages: 305-311, ISSN: 0267-1379

Journal article

Ralphs S, Khan SA, 2013, The role of the hepatitis viruses in cholangiocarcinoma, JOURNAL OF VIRAL HEPATITIS, Vol: 20, Pages: 297-305, ISSN: 1352-0504

Journal article

Ladep NG, Dona A, McPhail MJW, Shariff MI, Crossey MM, Wijeyesekera A, Okeke EN, Banwat E, Lemoine M, Njie R, Garside D, Khan SA, Thillainayagam AV, Thursz M, Holmes EC, Taylor-Robinson SDet al., 2013, URINARY METABOLIC PROFILE DISCRIMINATES HEPATOCELLULAR CARCINOMA BETTER THAN SERUM ALPHA FETOPROTEIN IN WEST AFRICANS, International Liver Congress / 48th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S49-S49, ISSN: 0168-8278

Conference paper

Zabron A, Edwards RJ, Khan SA, 2013, The challenge of cholangiocarcinoma: dissecting the molecular mechanisms of an insidious cancer, DISEASE MODELS & MECHANISMS, Vol: 6, Pages: 281-292, ISSN: 1754-8403

Journal article

Khan SA, Davidson BR, Goldin RD, Heaton N, Karani J, Pereira SP, Rosenberg WMC, Tait P, Taylor-Robinson SD, Thillainayagam AV, Thomas HC, Wasan Het al., 2012, Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update, GUT, Vol: 61, Pages: 1657-1669, ISSN: 0017-5749

Journal article

Zabron AA, Latif A, Horneffer-Van der Sluis V, Wadsworth C, Westaby D, Vlavianos P, Taylor-Robinson SD, Edwards R, Khan SAet al., 2012, BILIARY LIPOCALIN-2 (LCN2) IS INDEPENDENT OF MATRIXMETALLOPROTEINASE 9 (MMP9) IN MALIGNANT JAUNDICE, UEGW, Pages: A30-A30

Conference paper

Zabron AA, Frampton AE, Krell J, Castellano L, Stebbing J, Khan SA, Taylor-Robinson SD, Jiao LRet al., 2012, MicroRNAs in malignant bile as diagnostic biomarkers for pancreatic ductal adenocarcinoma., UEGW, Pages: A119-A119

Conference paper

Wadsworth CA, Horneffer-van der Sluis VM, Zabron A, Boberg KM, Pereira SP, Edwards RJ, Taylor-Robinson SD, Khan SAet al., 2012, INCREASED LEVELS OF NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN (NGAL) IN THE PLASMA OF CHOLANGIOCARCINOMA PATIENTS, GUT, Vol: 61, Pages: A350-A351, ISSN: 0017-5749

Journal article

Ladep NG, Khan SA, Thillainayagam AV, Taylor-Robinson SD, Toledano MBet al., 2012, RECENT TRENDS IN PRIMARY LIVER CANCER IN ENGLAND AND WALES, GUT, Vol: 61, Pages: A406-A407, ISSN: 0017-5749

Journal article

Shariff MIF, Keun HC, Beckonert O, Mohamed F, Jalan R, Khan SA, Holmes E, Taylor-Robinson SDet al., 2012, PLASMA METABOLITE PROFILING IN A RAT MODEL OF HEPATOCELLULAR CARCINOMA AND THE EFFECTS OF CO-ADMINISTERED ANTIBIOTICS, GUT, Vol: 61, Pages: A405-A406, ISSN: 0017-5749

Journal article

Shariff MIF, Lewis MR, Want EJ, Keun HC, Mohamed F, Jalan R, Ladep NG, Crossey MM, Khan SA, Holmes E, Taylor-Robinson SDet al., 2012, BLOOD LIPIDOMIC PROFILING OF HEPATOCELLULAR CARCINOMA IN HUMAN AND ANIMAL STUDIES IDENTIFIES LYSOPHOSPHATIDYLCHOLINE (24,0,0), A DISCRIMINATORY BIOMARKER

Poster

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