Imperial College London

Shahid A Khan

Faculty of MedicineFaculty of Medicine Centre

Professor of Practice (Haematology)
 
 
 
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Contact

 

+44 (0)20 3312 6254shahid.khan

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

135 results found

Fenton NK, Khan SA, Marcinkowski H, Cowan MLet al., 2012, A SPECIALIST CIRRHOSIS CLINIC IMPROVES SCREENING, PATIENT SATISFACTION AND ATTENDANCE OF PATIENTS WITH ADVANCED LIVER DISEASE, GUT, Vol: 61, Pages: A287-A287, ISSN: 0017-5749

Journal article

Pinato DJ, Stebbing J, Ishizuka M, Khan SA, Wasan HS, North BV, Kubota K, Sharma Ret al., 2012, A novel and validated prognostic index in hepatocellular carcinoma: The inflammation based index (IBI), Publisher: Elsevier, Pages: 1013-1020, ISSN: 1600-0641

Background & AimsOutcome prediction is uniquely different in hepatocellular carcinoma (HCC) as the progressive functional impairment of the liver impacts patient survival independently of tumour stage. As chronic inflammation is associated with the pathogenesis of HCC, we explored the prognostic impact of a panel of inflammatory based scores, including the modified Glasgow Prognostic Score (mGPS), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), in independent cohorts.MethodsInflammatory markers, Barcelona Clinic Liver Cancer (BCLC) and Cancer of the Liver Italian Program (CLIP) scores were studied in a training set of 112 patients with predominantly unresectable HCC (75%). Independent predictors of survival identified in multivariate analysis were validated in an independent cohort of 466 patients with an overall lower tumour burden (BCLC-A, 56%).ResultsIn both training and validation sets, mGPS and CLIP scores emerged as independent predictors of overall survival. The predictive accuracy of the combined mGPS and CLIP score (c score 0.7, 95% CI 0.6–0.8) appeared superior to that of the CLIP score alone (c score 0.6, 95% CI 0.5–0.7).ConclusionsSystemic inflammation as measured by the mGPS, independently predicts overall survival in HCC. We have validated a novel, easy to use inflammatory score that can be used to stratify individuals. These data enable formulation of a new prognostic system, the inflammation based index in HCC (IBI). Further validation of the IBI considering treatment allocation and survival is warranted in an independent patient cohort.

Conference paper

Patel M, Shariff MIF, Ladep NG, Thillainayagam AV, Thomas HC, Khan SA, Taylor-Robinson SDet al., 2012, Hepatocellular carcinoma: diagnostics and screening, JOURNAL OF EVALUATION IN CLINICAL PRACTICE, Vol: 18, Pages: 335-342, ISSN: 1356-1294

Journal article

Khan SA, Emadossadaty S, Ladep NG, Thomas HC, Elliott P, Taylor-Robinson SD, Toledano MBet al., 2012, Rising trends in cholangiocarcinoma: Is the ICD classification system misleading us?, JOURNAL OF HEPATOLOGY, Vol: 56, Pages: 848-854, ISSN: 0168-8278

Journal article

Shariff MIF, Keun HC, Beckonert O, Mohamed F, Jalan R, Khan SA, Holmes E, Taylor-Robinson SDet al., 2012, PLASMA METABOLITE PROFILING IN A RAT MODEL OF HEPATOCELLULAR CARCINOMA AND THE EFFECTS OF SELECTIVE GUT DECONTAMINATION, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S125-S126, ISSN: 0168-8278

Conference paper

Shariff MIF, Lewis MR, Want EJ, Keun HC, Mohamed F, Jalan R, Ladep NG, Crossey MME, Khan SA, Holmes E, Taylor-Robinson SDet al., 2012, BLOOD LIPIDOMIC PROFILING OF HEPATOCELLULAR CARCINOMA IN HUMAN AND ANIMAL STUDIES IDENTIFIES LYSOPHOSPHATIDYLCHOLINE (24,0,0) AS A DISCRIMINATORY BIOMARKER, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S294-S294, ISSN: 0168-8278

Conference paper

Ladep NG, Khan SA, Thillainayagam AV, Taylor-Robinson SD, Toledano MBet al., 2012, MORTALITY RATES OF PRIMARY LIVER CANCER ARE CONTINUING TO INCREASE GLOBALLY, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S287-S287, ISSN: 0168-8278

Conference paper

Wadsworth CA, Horneffer-van der Sluis VM, Zabron A, Boberg KM, Pereira SP, Taylor-Robinson SD, Edwards RJ, Khan SAet al., 2012, INCREASED LEVELS OF NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) IN THE PLASMA OF CHOLANGIOCARCINOMA PATIENTS, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S130-S130, ISSN: 0168-8278

Conference paper

Pinato DJ, Stebbing J, Ishizuka M, Khan SA, Wasan HS, North BV, Kubota K, Sharma Ret al., 2012, A novel and validated prognostic index in hepatocellular carcinoma: the Inflammation Based Index (IBI)., EASL International Liver Meeting

Conference paper

Khan SA, Toledano MB, Ahmed M, Zabron AA, Taylor-Robinson SDet al., 2012, Liver Cancer: The view from the United Kingdom, Clinical Dilemmas in Primary Liver Cancer, Editors: Williams, Taylor-Robinson, Publisher: Wiley, ISBN: 9780470657973

Incidence and mortality rates for both chronic liver disease (CLD) and liver cancer are increasing steadily in the United Kingdom. This is related to an increase in known risk factors. Alcohol consumption and non-alcoholic fatty liverdisease (NAFLD) have increased over recent decades. Chronic viral hepatitis has also increased because of increased immigration from hepatitis C virus(HBV)-endemic regions of the world and because of patients infected with hepatitis C virus (HCV) 20–30 years ago now presenting with clinical disease. There is currently a need for organised, formal hepatocellular carcinoma (HCC) surveillance, while increased incidence presents challenges for allocation of resources for treatment of HCC. Political help will be required, as the increasing health burden of liver disease raises public health issues in relation to health funding and addressing the underlying causes.

Book chapter

Khan SA, Toledano MB, Zabron A, Ahmed M, Taylor-Robinson SDet al., 2011, The view from the United Kingdom, Pages: 24-28

The incidence of chronic liver disease and, consequently, liver cancer is increasing in the United Kingdom at an alarming rate, and various reasons have been postulated. Alcohol consumption has increased over recent decades. The prevalence of non-alcoholic fatty liver disease has risen alongside obesity and diabetes. Chronic viral hepatitis infection are also on the rise due to increased immigration from HBV-endemic regions of the world and due to the cohort effect of previously infected HCV patients in the United Kingdom now presenting with liver disease. As well as being causes of cirrhosis, the background upon which most hepatocellular cancers (HCCs) arise, there is increasing evidence that each of these factors are independent risk factors for HCC carcinogenesis. The rising burden of chronic liver disease in the United Kingdom creates challenges for the surveillance and treatment of HCC and raises important public health issues in relation to health funding and tackling the underlying causes. © 2012 John Wiley & Sons, Ltd.

Journal article

Dixon PH, Wadsworth CA, Chambers J, Donnelly JC, Cooley SM, Kubitz R, Lammert F, Marschall H-U, Glantz A, Khan SA, Whittaker J, Geary M, Williamson Cet al., 2011, DOES COMMON GENETIC VARIATION AROUND THE PREGNANE-X RECEPTOR INFLUENCE SUSCEPTIBILITY TO INTRAHEPATIC CHOLESTASIS OF PREGNANCY?, 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), Publisher: WILEY-BLACKWELL, Pages: 924A-924A, ISSN: 0270-9139

Conference paper

Zabron AA, Horneffer-van der Sluis VM, Wadsworth CA, Laird F, Gierula M, Thillainayagam AV, Vlavianos P, Westaby D, Taylor-Robinson SD, Edwards RJ, Khan SAet al., 2011, Elevated Levels of Neutrophil Gelatinase-Associated Lipocalin in Bile From Patients With Malignant Pancreatobiliary Disease, AMERICAN JOURNAL OF GASTROENTEROLOGY, Vol: 106, Pages: 1711-1717, ISSN: 0002-9270

Journal article

AbdAlla MSH, Taylor-Robinson SD, Sharif AW, Williams HRT, Crossey MME, Badra GA, Thillainayagam AV, Bansi DS, Thomas HC, Waked IA, Khan SAet al., 2011, Differences in phosphatidylcholine and bile acids in bile from Egyptian and UK patients with and without cholangiocarcinoma, HPB, Vol: 13, Pages: 385-390, ISSN: 1365-182X

Journal article

Shariff MIF, Gomaa AI, Cox IJ, Patel M, Williams HRT, Crossey MME, Thillainayagam AV, Thomas HC, Waked I, Khan SA, Taylor-Robinson SDet al., 2011, Urinary Metabolic Biomarkers of Hepatocellular Carcinoma in an Egyptian Population: A Validation Study, JOURNAL OF PROTEOME RESEARCH, Vol: 10, Pages: 1828-1836, ISSN: 1535-3893

Journal article

Wadsworth CA, Dixon PH, Zabron AA, Wong JH, Chapman MH, McKay SC, Spalding DR, Pereira SP, Wasan HS, Thomas HC, Taylor-Robinson SD, Whittaker JC, Williamson C, Khan SAet al., 2011, GENETIC VARIATION IN NATURAL KILLER CELL RECEPTOR PROTEIN G2D DOES NOT MODIFY SUSCEPTIBILITY TO SPORADIC CHOLANGIOCARCINOMA, Annual Meeting on British-Society-of-Gasenterology, Publisher: B M J PUBLISHING GROUP, ISSN: 0017-5749

Conference paper

Wadsworth CA, Dixon PH, Zabron AA, Wong JH, Chapman MH, McKay SC, Spalding DR, Pereira SP, Wasan HS, Thomas HC, Taylor-Robinson SD, Whittaker JC, Williamson C, Khan SAet al., 2011, COMMON GENETIC VARIATION IN NATURAL KILLER CELL RECEPTOR PROTEIN G2D DOES NOT MODIFY SUSCEPTIBILITY TO SPORADIC CHOLANGIOCARCINOMA, 46th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S108-S109, ISSN: 0168-8278

Conference paper

Wadsworth CA, Dixon PH, Zabron AA, Wong JH, Chapman MH, McKay SC, Sharif AW, Spalding DR, Pereira SP, Wasan HS, Thomas HC, Taylor-Robinson SD, Whittaker JC, Williamson C, Khan SAet al., 2011, GENETIC VARIATION IN BILIARY TRANSPORTERS AS A SUSCEPTIBILITY FACTOR FOR CHOLANGIOCARCINOMA, 46th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S109-S109, ISSN: 0168-8278

Conference paper

Wadsworth CA, Dixon PH, Wong JH, Chapman MH, McKay SC, Sharif A, Spalding DR, Pereira SP, Thomas HC, Taylor-Robinson SD, Whittaker J, Williamson C, Khan SAet al., 2011, Genetic Factors in the Pathogenesis of Cholangiocarcinoma, DIGESTIVE DISEASES, Vol: 29, Pages: 93-97, ISSN: 0257-2753

Journal article

Asgheddi M, Abdullah M, ODonoghue M, Campbell L, Lalvani A, Wickremasinghe M, Kon OM, Khan SAet al., 2010, PREVALENCE OF VIRAL HEPATITIS IN PATIENTS UNDERGOING ANTI-TUBERCULOSIS THERAPY IN WEST LONDON, 61st Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Publisher: WILEY-BLACKWELL, Pages: 685A-686A, ISSN: 0270-9139

Conference paper

Dixon PH, Wadsworth CA, Chambers J, Donnelly J, Cooley SM, Jarvis S, Kubitz R, Lammert F, Marschall H-U, Glantz A, Khan SA, Whittaker J, Geary M, Williamson Cet al., 2010, THE ROLE OF COMMON GENETIC VARIATION AROUND SIX CANDIDATE LOCI FOR SUSCEPTIBILITY TO INTRAHEPATIC CHOLESTASIS OF PREGNANCY, 61st Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Publisher: WILEY-BLACKWELL, Pages: 479A-479A, ISSN: 0270-9139

Conference paper

Sharif AW, Williams HRT, Lampejo T, Khan SA, Bansi DS, Westaby D, Thillainayagam AV, Thomas HC, Cox IJ, Taylor-Robinson SDet al., 2010, Metabolic profiling of bile in cholangiocarcinoma using in vitro magnetic resonance spectroscopy, HPB, Vol: 12, Pages: 396-402, ISSN: 1365-182X

Journal article

Zabron AA, Horneffer-Van der Sluis VM, Geirula M, Wadsworth CA, Laird F, Thillainayagam AV, Vlavianos P, Westaby D, Taylor-Robinson SD, Edwards RJ, Khan SAet al., 2010, PROTEOMIC ANALYSIS OF BILE IN BENIGN AND MALIGNANT PANCREATOBILIARY DISEASE, Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A82-A83, ISSN: 0017-5749

Conference paper

Mullish BH, Khan SA, 2010, Ascites, Student BMJ, Vol: 18

Journal article

Shariff MIF, Ladep NG, Cox IJ, Williams HRT, Okeke E, Malu A, Thillainayagam AV, Crossey MME, Khan SA, Thomas HC, Taylor-Robinson SDet al., 2010, Characterization of Urinary Biomarkers of Hepatocellular Carcinoma Using Magnetic Resonance Spectroscopy in a Nigerian Population, JOURNAL OF PROTEOME RESEARCH, Vol: 9, Pages: 1096-1103, ISSN: 1535-3893

Journal article

Khan SA, Emadossadaty S, Taylor-Robinson SD, Elliott P, Thomas HC, Toledano MBet al., 2010, MISCLASSIFICATION OF HILAR (KLATSKIN) CHOLANGIOCARCINOMAS: AN INVESTIGATION OF CODING PRACTICE IN THE UK, 45th Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S221-S221, ISSN: 0168-8278

Conference paper

Tanwar S, Khan SA, Grover VPB, Gwilt C, Smith B, Brown Aet al., 2009, Liver transplantation for hepatocellular carcinoma, WORLD JOURNAL OF GASTROENTEROLOGY, Vol: 15, Pages: 5511-5516, ISSN: 1007-9327

Journal article

Wadsworth CA, Young IR, Rea M, Ahmad MM, Khorsandi SE, Davidson B, Khan S, Taylor-Robinson SD, Syms RRet al., 2009, A CATHETER-MOUNTED MAGNETIC RESONANCE DETECTOR COIL FOR BILIARY IMAGING: FIRST EX VIVO HUMAN HEPATOBILIARY IMAGES, 60th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Publisher: JOHN WILEY & SONS INC, Pages: 740A-741A, ISSN: 0270-9139

Conference paper

Adenugba A, Khan SA, Taylor-Robinson SD, Cox IJ, Toledano MB, Thillainayagam AV, Bansi DS, Thomas HC, Gibson RW, Beck AJet al., 2009, Polychlorinated biphenyls in bile of patients with biliary tract cancer, CHEMOSPHERE, Vol: 76, Pages: 841-846, ISSN: 0045-6535

Journal article

Shariff MIF, Cox IJ, Gomaa AI, Khan SA, Gedroyc W, Taylor-Robinson SDet al., 2009, Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis and therapeutics., Expert Rev Gastroenterol Hepatol, Vol: 3, Pages: 353-367

Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide and, owing to changes in the prevalence of the two major risk factors, hepatitis B virus and hepatitis C virus, its overall incidence remains alarmingly high in the developing world and is steadily rising across most of the developed world. Early diagnosis remains the key to effective treatment and there have been recent advances in both the diagnosis and therapy of HCC, which have made important impacts on the disease. This review outlines the epidemiological trends, risk factors, diagnostic developments and novel therapeutics for HCC, both in the developing and developed world.

Journal article

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