Imperial College London

Shahid A Khan

Faculty of MedicineFaculty of Medicine Centre

Professor of Practice (Haematology)
 
 
 
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Contact

 

+44 (0)20 3312 6254shahid.khan

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Howell:2016:10.1016/j.trsl.2016.12.006,
author = {Howell, JA and Khan, SA and Knapp, S and Thursz, MR and Sharma, R},
doi = {10.1016/j.trsl.2016.12.006},
journal = {Translational Research},
pages = {137--154},
title = {The clinical role of circulating free tumor DNA in gastrointestinal malignancy},
url = {http://dx.doi.org/10.1016/j.trsl.2016.12.006},
volume = {183},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Circulating cell-free DNA (cfDNA) is DNA released from necrotic or apoptotic cells into the bloodstream. While both healthy cells and cancer cells release cfDNA, tumors are associated with higher levels of tumor-derived circulating cell-free DNA (ctDNA) detectable in blood. Absolute levels of ctDNA and its genetic mutations and epigenetic changes show promise as potentially useful biomarkers of tumor biology, progression, and response to therapy. Moreover, studies have demonstrated the discriminative accuracy of ctDNA levels for diagnosis of gastrointestinal cancer compared with benign inflammatory diseases. Therefore, ctDNA detected in blood offers a minimally invasive and easily repeated "liquid biopsy" of cancer, facilitating real-time dynamic analysis of tumor behavior that could revolutionize both clinical and research practices in oncology. In this review, we provide a critical summary of the evidence for the utility of ctDNA as a diagnostic and prognostic biomarker in gastrointestinal malignancies.
AU - Howell,JA
AU - Khan,SA
AU - Knapp,S
AU - Thursz,MR
AU - Sharma,R
DO - 10.1016/j.trsl.2016.12.006
EP - 154
PY - 2016///
SN - 1931-5244
SP - 137
TI - The clinical role of circulating free tumor DNA in gastrointestinal malignancy
T2 - Translational Research
UR - http://dx.doi.org/10.1016/j.trsl.2016.12.006
UR - http://www.ncbi.nlm.nih.gov/pubmed/28056336
UR - http://hdl.handle.net/10044/1/44120
VL - 183
ER -