Publications
165 results found
Ladep NG, Dona AC, Lewis MR, et al., 2014, Discovery and Validation of Urinary Metabotypes for the Diagnosis of Hepatocellular Carcinoma in West Africans, HEPATOLOGY, Vol: 60, Pages: 1291-1301, ISSN: 0270-9139
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- Citations: 59
Mukherjee S, Khan SA, Toledano MB, et al., 2014, THE BURDEN OF CYSTIC FIBROSIS ASSOCIATED LIVER DISEASE IN THE UNITED KINGDOM: A NATIONAL REGISTRY REVIEW, 2008-2012, PEDIATRIC PULMONOLOGY, Vol: 49, Pages: 414-415, ISSN: 8755-6863
Bridgewater J, Galle PR, Khan SA, et al., 2014, Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma, JOURNAL OF HEPATOLOGY, Vol: 60, Pages: 1268-1289, ISSN: 0168-8278
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- Citations: 954
Ladep NG, Lewis M, Gomez-Romero M, et al., 2014, BIOMARKER DISCOVERY USING ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY QUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETRY IDENTIFIES DIAGNOSTIC URINARY METABOLIC PANELS FOR HCC IN AFRICANS, 49th Annual International Liver Congress of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S256-S256, ISSN: 0168-8278
Vergis N, Khamri W, Atkinson S, et al., 2014, Monocyte oxidative burst defect predicts risk of infection in alcoholic hepatitis, International Liver Conference 2014/ 49th Annual Meeting of the European Association for the Study of the Liver, Publisher: Elsevier Science BV, Pages: S168-S168, ISSN: 0168-8278
Ladep NG, Khan SA, Crossey MME, et al., 2014, Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations, WORLD JOURNAL OF GASTROENTEROLOGY, Vol: 20, Pages: 1544-1553, ISSN: 1007-9327
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- Citations: 32
Dixon PH, Wadsworth CA, Chambers J, et al., 2014, A Comprehensive Analysis of Common Genetic Variation Around Six Candidate Loci for Intrahepatic Cholestasis of Pregnancy, AMERICAN JOURNAL OF GASTROENTEROLOGY, Vol: 109, Pages: 76-84, ISSN: 0002-9270
Khan SA, 2014, Interview: Challenges and prospects for liver cancer management: treatment, prevention and collaboration., Hepat Oncol, Vol: 1, Pages: 17-21
Dr Shahid Khan qualified in Medicine at Guys Hospital Medical School (London, UK) in 1994. His studies in liver cancer led to a PhD from the University of London in 2003 and he was appointed Consultant in Gastroenterology and Hepatology at St Mary's and Hammersmith Hospitals, Imperial College London Healthcare NHS Trust; and a Clinical Senior Lecturer at Imperial College London in 2007. Dr Khan has lectured on liver disease nationally and internationally at hepatology and gastroenterology conferences, including state-of-the-art and invited presentations. He is the lead author on the UK National Guidelines for biliary cancer and was on the International Liver Cancer Association panel for the International Guidelines. He has published extensively in the medical literature, including original research articles, reviews and book chapters. Dr Khan is a Fellow of the Royal College of Physicians of the UK, and a member of the British Medical Association, the British Association for the Study of the Liver, the British Society of Gastroenterology, the European Association for the Study of the Liver, the American Association for the Study of the Liver Diseases and the International Liver Cancer Association.
Crawford-Smith H, Mullish BH, McPhail MJW, et al., 2013, An Investigation of the Correlation Between Transient Elastography using FibroScan™ and Liver Biopsy in the Assessment of Liver Fibrosis., BASL Annual Meeting 2013
Shariff MIF, Khan SA, Westaby D, 2013, The palliation of cholangiocarcinoma, CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE, Vol: 7, Pages: 168-174, ISSN: 1751-4258
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- Citations: 12
Wadsworth CA, Lim A, Taylor-Robinson SD, et al., 2013, The risk factors and diagnosis of cholangiocarcinoma, HEPATOLOGY INTERNATIONAL, Vol: 7, Pages: 377-393, ISSN: 1936-0533
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- Citations: 8
Zabron A, Frampton A, Krell J, et al., 2013, SPECIFIC MICRORNA MARKERS ARE IDENTIFIED IN BILE IN PANCREATIC DUCTAL ADENOCARCINOMA, Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: BMJ PUBLISHING GROUP, Pages: A17-A17, ISSN: 0017-5749
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- Citations: 1
Wadsworth CA, Horneffer-van der Sluis VM, Zabron A, et al., 2013, DISCOVERY OF POTENTIAL PLASMA BIOMARKERS OF CHOLANGIOCARCINOMA UTILISING SURFACE-ENHANCED LASER DESORPTION/IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY (SELDI-TOF MS), Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: BMJ PUBLISHING GROUP, Pages: A86-A86, ISSN: 0017-5749
Zabron A, Frampton A, Krell J, et al., 2013, BILIARY MICRORNA MARKERS IN BILE AID THE DIAGNOSIS OF CHOLANGIOCARCINOMA AT ERCP, Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: BMJ PUBLISHING GROUP, Pages: A80-A80, ISSN: 0017-5749
Wadsworth CA, Westaby D, Khan SA, 2013, Endoscopic radiofrequency ablation for cholangiocarcinoma, CURRENT OPINION IN GASTROENTEROLOGY, Vol: 29, Pages: 305-311, ISSN: 0267-1379
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- Citations: 32
Ralphs S, Khan SA, 2013, The role of the hepatitis viruses in cholangiocarcinoma, JOURNAL OF VIRAL HEPATITIS, Vol: 20, Pages: 297-305, ISSN: 1352-0504
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- Citations: 26
Ladep NG, Dona A, McPhail MJW, et al., 2013, URINARY METABOLIC PROFILE DISCRIMINATES HEPATOCELLULAR CARCINOMA BETTER THAN SERUM ALPHA FETOPROTEIN IN WEST AFRICANS, International Liver Congress / 48th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S49-S49, ISSN: 0168-8278
Zabron A, Edwards RJ, Khan SA, 2013, The challenge of cholangiocarcinoma: dissecting the molecular mechanisms of an insidious cancer, DISEASE MODELS & MECHANISMS, Vol: 6, Pages: 281-292, ISSN: 1754-8403
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- Citations: 63
Khan SA, Davidson BR, Goldin RD, et al., 2012, Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update, GUT, Vol: 61, Pages: 1657-1669, ISSN: 0017-5749
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- Citations: 570
Zabron AA, Frampton AE, Krell J, et al., 2012, MicroRNAs in malignant bile as diagnostic biomarkers for pancreatic ductal adenocarcinoma., UEGW, Pages: A119-A119
Zabron AA, Latif A, Horneffer-Van der Sluis V, et al., 2012, BILIARY LIPOCALIN-2 (LCN2) IS INDEPENDENT OF MATRIXMETALLOPROTEINASE 9 (MMP9) IN MALIGNANT JAUNDICE, UEGW, Pages: A30-A30
Shariff MIF, Keun HC, Beckonert O, et al., 2012, PLASMA METABOLITE PROFILING IN A RAT MODEL OF HEPATOCELLULAR CARCINOMA AND THE EFFECTS OF CO-ADMINISTERED ANTIBIOTICS, GUT, Vol: 61, Pages: A405-A406, ISSN: 0017-5749
Shariff MIF, Lewis MR, Want EJ, et al., 2012, BLOOD LIPIDOMIC PROFILING OF HEPATOCELLULAR CARCINOMA IN HUMAN AND ANIMAL STUDIES IDENTIFIES LYSOPHOSPHATIDYLCHOLINE (24,0,0), A DISCRIMINATORY BIOMARKER
Fenton NK, Khan SA, Marcinkowski H, et al., 2012, A SPECIALIST CIRRHOSIS CLINIC IMPROVES SCREENING, PATIENT SATISFACTION AND ATTENDANCE OF PATIENTS WITH ADVANCED LIVER DISEASE, GUT, Vol: 61, Pages: A287-A287, ISSN: 0017-5749
Wadsworth CA, Horneffer-van der Sluis VM, Zabron A, et al., 2012, INCREASED LEVELS OF NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN (NGAL) IN THE PLASMA OF CHOLANGIOCARCINOMA PATIENTS, GUT, Vol: 61, Pages: A350-A351, ISSN: 0017-5749
Ali A, Swingland J, Choi CH, et al., 2012, ARTIFICIAL NEURAL NETWORK FOR THE RISK STRATIFICATION OF ACUTE UPPER GASTROINTESTINAL BLEEDING: MULTICENTRE COMPARATIVE ANALYSIS VS THE GLASGOW BLATCHFORD AND ROCKALL SCORES, GUT, Vol: 61, Pages: A62-A62, ISSN: 0017-5749
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- Citations: 2
Latif A, Zabron A, Horneffer-Van der Sluis V, et al., 2012, BILIARY MATRIX METALLOPROTEINASE 9 LEVELS ARE INDEPENDENT OF NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN IN PATIENTS WITH MALIGNANT BILIARY OBSTRUCTION, GUT, Vol: 61, Pages: A211-A212, ISSN: 0017-5749
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- Citations: 1
Vergis N, Antoniades CG, Zingarelli V, et al., 2012, FUNCTIONAL DEFECTS IN CIRCULATING MONOCYTES MAY CONTRIBUTE TO SUSCEPTIBILITY TO INFECTION IN ALCOHOLIC HEPATITIS, GUT, Vol: 61, Pages: A189-A190, ISSN: 0017-5749
Ladep NG, Khan SA, Thillainayagam AV, et al., 2012, RECENT TRENDS IN PRIMARY LIVER CANCER IN ENGLAND AND WALES, GUT, Vol: 61, Pages: A406-A407, ISSN: 0017-5749
Pinato DJ, Stebbing J, Ishizuka M, et al., 2012, A novel and validated prognostic index in hepatocellular carcinoma: The inflammation based index (IBI), Publisher: Elsevier, Pages: 1013-1020, ISSN: 1600-0641
Background & AimsOutcome prediction is uniquely different in hepatocellular carcinoma (HCC) as the progressive functional impairment of the liver impacts patient survival independently of tumour stage. As chronic inflammation is associated with the pathogenesis of HCC, we explored the prognostic impact of a panel of inflammatory based scores, including the modified Glasgow Prognostic Score (mGPS), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), in independent cohorts.MethodsInflammatory markers, Barcelona Clinic Liver Cancer (BCLC) and Cancer of the Liver Italian Program (CLIP) scores were studied in a training set of 112 patients with predominantly unresectable HCC (75%). Independent predictors of survival identified in multivariate analysis were validated in an independent cohort of 466 patients with an overall lower tumour burden (BCLC-A, 56%).ResultsIn both training and validation sets, mGPS and CLIP scores emerged as independent predictors of overall survival. The predictive accuracy of the combined mGPS and CLIP score (c score 0.7, 95% CI 0.6–0.8) appeared superior to that of the CLIP score alone (c score 0.6, 95% CI 0.5–0.7).ConclusionsSystemic inflammation as measured by the mGPS, independently predicts overall survival in HCC. We have validated a novel, easy to use inflammatory score that can be used to stratify individuals. These data enable formulation of a new prognostic system, the inflammation based index in HCC (IBI). Further validation of the IBI considering treatment allocation and survival is warranted in an independent patient cohort.
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