Imperial College London

ProfessorSianHarding

Faculty of MedicineNational Heart & Lung Institute

Emeritus Professor of Cardiac Pharmacology
 
 
 
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Contact

 

+44 (0)20 7594 3009sian.harding Website

 
 
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Location

 

435ICTEM buildingHammersmith Campus

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Summary

 

Summary

Sian Harding is Professor of Cardiac Pharmacology at the National Heart and Lung Institute, Imperial College London, and Director of the Imperial Cardiac Regenerative Medicine Centre https://www.imperial.ac.uk/bhf-regenerative-medicine/.

She obtained her Ph.D. in Pharmacology from King's College, London in 1981, and since then the primary focus of her work has been cardiomyocyte function in the failing heart. This has extended to gene therapy to modulate cardiomyocyte function, and she was Scientific PI for the UK's first clinical trial on myocardial gene therapy. More recently the scope has extended to the characterisation of cardiomyocytes derived from embryonic stem cells, and their use in cardiac repair, tissue engineering and drug discovery.

Professor Harding is Past-President of the European Section of the International Society for Heart Research, is on the Board of the British Society for Gene and Cell Therapy and has been elected as a Fellow to the AHA, ESC and ISHR. She was Special Advisor to the House of Commons Science and Technology Select Committee on Regenerative Medicine and is now a member of the CGT Catapult: Pluripotent stem cells programme Advisory Panel.

Professor Harding delivered her Inaugural Lecture, entitled 'Reviving the Failing Heart: one cell at a time', on 3 April 2007.  The abstract and other details of the lecture can be found here.

 

 

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Publications

Journals

Todorova VB, Baxan N, Delahaye M, et al., 2023, Drug-based mobilisation of mesenchymal stem/stromal cells improves cardiac function post myocardial infarction., Dis Model Mech, Vol:16

Tranter MH, Redfors B, Wright PT, et al., 2022, Hyperthermia as a trigger for Takotsubo syndrome in a rat model (vol 9, 869585, 2022), Frontiers in Cardiovascular Medicine, Vol:9, ISSN:2297-055X

Tranter MH, Redfors B, Wright PT, et al., 2022, Hyperthermia as a trigger for Takotsubo syndrome in a rat model, Frontiers in Cardiovascular Medicine, Vol:9, Pages:1-9

Couch LS, Fiedler J, Chick G, et al., 2022, Circulating microRNAs predispose to takotsubo syndrome following high-dose adrenaline exposure, Cardiovascular Research, Vol:118, ISSN:0008-6363, Pages:1758-1770

Fassina D, Costa CM, Longobardi S, et al., 2022, Modelling the interaction between stem cells derived cardiomyocytes patches and host myocardium to aid non-arrhythmic engineered heart tissue design, Plos Computational Biology, Vol:18, ISSN:1553-734X

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