Publications
464 results found
Shah M, Sikkel MB, Desplantez T, et al., 2012, Flecainide reduces wave frequency and mean spark amplitude in isolated rat ventricular cardiomyocytes, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S89-S90, ISSN: 0008-6363
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- Citations: 1
Kolker L, Ali NN, Maclellan K, et al., 2012, The effect of triiodothyronine hormone on human iPSC-derived cardiomyocyte maturation, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S58-S58, ISSN: 0008-6363
Mills AM, Collins T, O'gara P, et al., 2012, Induced downregulation of miR-1 expression in cultured adult rat cardiomyocytes replicates the elevated NCX function observed in heart failure, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S68-S68, ISSN: 0008-6363
Mioulane M, Foldes G, Harding SE, 2012, Cardiotoxicity of chemotherapeutic agents assessed in human embryonic or induced pluripotent stem cell-derived cardiomyocytes, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S47-S47, ISSN: 0008-6363
Wright PT, Diakonov I, Tokar S, et al., 2012, Beta-2 adrenergic receptor signaling in adult rat ventricular myocytes at 4, 8 and 16 weeks after myocardial infarction, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S24-S24, ISSN: 0008-6363
Collins TP, Sikkel MB, Gara PO, et al., 2012, Is SERCA overexpression anti- or pro-arrhythmic?, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S5-S5, ISSN: 0008-6363
Wright PT, Pannell LMK, Lyon AR, et al., 2012, The negatively inotropic effect of adrenaline stress is not completely linked to the reduction of cAMP release mediated by the Gs/Gi switch, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S18-S18, ISSN: 0008-6363
Tokar S, Schobesberger S, Singh A, et al., 2012, Progressive changes in cardiomyocyte structure and beta-2 adrenergic receptors cAMP signaling localisation in a rat model of myocardial infarction, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S48-S48, ISSN: 0008-6363
Foldes G, Maxime M, Ali NN, et al., 2012, Modulating cell survival of human embryonic stem cell derivatives by immunosuppressive drugs, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S99-S99, ISSN: 0008-6363
Johnson WB, Katugampola S, Able S, et al., 2012, Profiling of cAMP and cGMP phosphodiesterases in isolated ventricular cardiomyocytes from human hearts: Comparison with rat and guinea pig, LIFE SCIENCES, Vol: 90, Pages: 328-336, ISSN: 0024-3205
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- Citations: 58
Tremoleda JL, de Lecuona I, Harding SE, 2012, Technical and bioethical challenges associated with using stem cells for research and therapy, Regenerative Medicine, Stem Cells and the Liver, Pages: 154-188, ISBN: 9781578087396
Millions of patients worldwide suffer from end-stage liver disease. Orthotopic liver transplantation has rapidly advanced and is currently the treatment of choice for patient with end-stage liver disease. However, the procedure requires major surgery, with many liver transplant recipients needing to spend time in intensive care units in the post-operative period, with considerable risks for infectious complications, acute renal failure and/or poorly functioning grafts (Razonable et al. 2011). Given the donor shortage and that only one or two patients at most may benefit from one donor liver, and the complexity associated with the transplantation procedure various alternatives have been evaluated, including cell therapies. The use of living cells as a therapeutic source to restore, maintain and/or enhance the liver function have numerous advantages when compared to organ transplantation as cells can be expanded in vitro to overcome the limits of organ shortage, cells can be genetically manipulated to correct functional and/or metabolic alterations, cells can be cryopreserved, transplanted without major surgical procedures and can be obtained from the same patients avoiding major risk of rejection and need for immunosuppressive treatments (Locke et al. 2009).Unfortunately adult hepatocytes cannot be expanded in vitro and cryopreserved cells are easily damaged during the freezing/thawing procedure.
Antkowiak M, Torres-Mapa ML, McGinty J, et al., 2012, Towards gene therapy based on femtosecond optical transfection, BIOPHOTONICS: PHOTONIC SOLUTIONS FOR BETTER HEALTH CARE III, Vol: 8427, ISSN: 0277-786X
Lyon AR, Nikolaev VO, Miragoli M, et al., 2012, Plasticity of surface structures and β(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure, Circulation: Heart Failure, Vol: 5, Pages: 357-365
Kumaraswamy R, Lyon AR, Volkman I, et al., 2012, SERCA2a gene therapy restores microRNA-1 1 expression in heart failure via an AKT/FoxO3A-dependent pathway, E. Heart J., Vol: 33, Pages: 1067-1075
Song X, Baimpas N, Harding S, et al., 2011, Process modelling of Linear Friction Welding (LFW) between Aa2124/Sic <inf>P</inf> composite and unreinforced alloy, Pages: 1379-1387
In the present study, the Linear Friction Welding (LFW) process between a bar of Metal Matrix Composite (MMC) AMC225xe (AA2124 with 25% SiC particulate reinforcement) and a bar of unreinforced base alloy was simulated using the commercial finite element package ABAQUS TM. Fully coupled implicit thermo-mechanical analysis procedure was employed, with semi-automatic re-meshing using Python scripting and output database scripting methods for extracting deformed configurations. Due to the large deformation near the weld region, multiple analyses were carried out between each re-meshing stage in order to limit the element distortion. Comparison of the simulation results with the experimental data collected during welding, and with post-weld optical section micrograph has shown satisfactory agreement.
Siedlecka U, Navaratnarajah M, Gandhi A, et al., 2011, Clenbuterol Affects Cardiomyocyte Contractility Via A β2-Adrenoceptor Independent Pathway, CIRCULATION, Vol: 124, ISSN: 0009-7322
Lyon AR, Nikolaev VO, Miragoli M, et al., 2011, Plasticity of Surface Structures and Beta 2-adrenergic Receptor Localization in Failing Ventricular Cardiomyocytes During Recovery From Heart Failure, CIRCULATION, Vol: 124, ISSN: 0009-7322
Rees PSC, Davidson SM, Harding SE, et al., 2011, The Mitochondrial Permeability Transition Pore is a Target for Pharmacological Cardioprotection in Human Hypertrophic Cardiomyopathy, 23rd Annual Transcatheter Cardiovascular Therapeutics (TCT) Symposium, Publisher: ELSEVIER SCIENCE INC, Pages: B119-B119, ISSN: 0735-1097
Quinn TA, Granite S, Allessie MA, et al., 2011, Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing, Progress in Biophysics and Molecular Biology, Vol: 107, Pages: 4-10, ISSN: 0079-6107
Cardiac experimental electrophysiology is in need of a well-defined Minimum Information Standard for recording, annotating, and reporting experimental data. As a step towards establishing this, we present a draft standard, called Minimum Information about a Cardiac Electrophysiology Experiment (MICEE). The ultimate goal is to develop a useful tool for cardiac electrophysiologists which facilitates and improves dissemination of the minimum information necessary for reproduction of cardiac electrophysiology research, allowing for easier comparison and utilisation of findings by others. It is hoped that this will enhance the integration of individual results into experimental, computational, and conceptual models. In its present form, this draft is intended for assessment and development by the research community. We invite the reader to join this effort, and, if deemed productive, implement the Minimum Information about a Cardiac Electrophysiology Experiment standard in their own work.
Chahine MN, Mioulane M, Foldes G, et al., 2011, NUCLEAR PROTEIN IMPORT MEDIATES PHENYLEPHRINE-INDUCED HYPERTROPHY IN ADULT AND HUMAN EMBRYONIC STEM CELL-DERIVED CARDIOMYOCYTES, HEART, Vol: 97, Pages: 10-10, ISSN: 1355-6037
Foldes G, Mioulane M, Chahine MN, et al., 2011, HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES SERVE AS IN VITRO MODEL OF CARDIAC HYPERTROPHY (Retracted article. See vol. 99, pg. 00, 2013), HEART, Vol: 97, Pages: 11-11, ISSN: 1355-6037
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- Citations: 3
Földes G, Harding SE, 2011, Stem Cell Therapy to Treat Heart Failure, Comprehensive Biotechnology, Second Edition, Pages: 407-423, ISBN: 9780444533524
Stem cells have emerged as a justifiable medical therapy for patients with heart failure. Many cell types have been contemplated during the last years, and promising preclinical and clinical data are available on their efficacy and safety in the setting of acute myocardial infarction and heart failure. However, there are still many hurdles to be overcome for the routine clinical application of these cells. A better understanding of the biology of stem cells will help in the design of future strategies for cardiac regeneration.
Jawad H, Boccaccini AR, Ali NN, et al., 2011, Assessment of cellular toxicity of TiO<sub>2</sub> nanoparticles for cardiac tissue engineering applications, NANOTOXICOLOGY, Vol: 5, Pages: 372-380, ISSN: 1743-5390
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- Citations: 36
Song W, Dyer E, Stuckey DJ, et al., 2011, Molecular Mechanism of the E99K Mutation in Cardiac Actin (<i>ACTC</i> Gene) That Causes Apical Hypertrophy in Man and Mouse, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 286, Pages: 27582-27593
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- Citations: 45
Pathan N, Franklin JL, Eleftherohorinou H, et al., 2011, Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase, CRITICAL CARE MEDICINE, Vol: 39, Pages: 1692-1711, ISSN: 0090-3493
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- Citations: 42
Lyon AR, Bannister ML, Collins T, et al., 2011, SERCA2a Gene Transfer Decreases Sarcoplasmic Reticulum Calcium Leak and Reduces Ventricular Arrhythmias in a Model of Chronic Heart Failure, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, Vol: 4, Pages: 362-372, ISSN: 1941-3149
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- Citations: 135
Reed DM, Foldes G, Badiger RV, et al., 2011, TLR3 AND INTERFERON FUNCTION IN HUMAN EMBRYONIC STEM CELL-DERIVED ENDOTHELIAL CELLS (HESC-EC): RELEVANCE TO VIRAL IMMUNITY, Heart
Reed DM, Foldes G, Gatheral T, et al., 2011, ENDOTHELIN-1 RELEASE FROM HUMAN EMBRYONIC STEM CELL DERIVED-ENDOTHELIAL CELLS (HESC-EC): COMPARISONS WITH HUMAN ENDOTHELIAL CELLS, 10th World Congress on Inflammation, Publisher: BIRKHAUSER VERLAG AG, Pages: 224-224, ISSN: 1023-3830
Miragoli M, Moshkov A, Novak P, et al., 2011, Scanning ion conductance microscopy: a convergent high-resolution technology for multi-parametric analysis of living cardiovascular cells, Journal of the Royal Society Interface, Vol: 8, Pages: 913-925, ISSN: 1742-5662
Cardiovascular diseases are complex pathologies that include alterations of various cell functions at the levels of intact tissue, single cells and subcellular signalling compartments. Conventional techniques to study these processes are extremely divergent and rely on a combination of individual methods, which usually provide spatially and temporally limited information on single parameters of interest. This review describes scanning ion conductance microscopy (SICM) as a novel versatile technique capable of simultaneously reporting various structural and functional parameters at nanometre resolution in living cardiovascular cells at the level of the whole tissue, single cells and at the subcellular level, to investigate the mechanisms of cardiovascular disease. SICM is a multimodal imaging technology that allows concurrent and dynamic analysis of membrane morphology and various functional parameters (cell volume, membrane potentials, cellular contraction, single ion-channel currents and some parameters of intracellular signalling) in intact living cardiovascular cells and tissues with nanometre resolution at different levels of organization (tissue, cellular and subcellular levels). Using this technique, we showed that at the tissue level, cell orientation in the inner and outer aortic arch distinguishes atheroprone and atheroprotected regions. At the cellular level, heart failure leads to a pronounced loss of T-tubules in cardiac myocytes accompanied by a reduction in Z-groove ratio. We also demonstrated the capability of SICM to measure the entire cell volume as an index of cellular hypertrophy. This method can be further combined with fluorescence to simultaneously measure cardiomyocyte contraction and intracellular calcium transients or to map subcellular localization of membrane receptors coupled to cyclic adenosine monophosphate production. The SICM pipette can be used for patch-clamp recordings of membrane potential and single channel currents. In conclusio
Michel MC, Harding SE, Bond RA, 2011, Are there functional β<sub>3</sub>-adrenoceptors in the human heart?, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 162, Pages: 817-822, ISSN: 0007-1188
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- Citations: 29
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