Imperial College London
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ProfessorSianHarding

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Cardiac Pharmacology
 
 
 
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Contact

 

+44 (0)20 7594 3009sian.harding Website

 
 
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Location

 

435ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Dubey:2019,
author = {Dubey, P and Humphrey, E and Majid, Q and Grigsby, C and Stevens, MM and Terracciano, C and Harding, SE and Roy, I},
title = {Polyhydroxyalkanoates, ideal materials for cardiac regeneration},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - Statement of purpose: Polyhydroxyalkanoates (PHAs), a family of biodegradable and biocompatible polymers with a range of material properties and degradation rates are known to be particularly cardio-regenerative in nature1,2,3. Myocardial infarction results in the generation of scar tissue with limited or no regeneration due to the modest nature of intrinsic myocardial regenerative capability. The concept of a cardiac patch is tailored to meet the unmet medical need of cardiac regeneration where a biomaterial-based patch with/without cells would be used to induce efficient cardiac regeneration. Medium chain length PHAs (MCL-PHAs) with monomer chain length between C6-C16 are highly elastomeric in nature1,2 and have been shown to be excellent substrates for the growth and function of neonatal cardiomyocytes3. This work describes an in-depth study of the potential of MCL-PHAs for the development of functional cardiac patches laden with human pluripotent stem cell derived cardiomyocytes (hiPSC-CMs), providing mechanical support and cell based therapy.
AU  - Dubey,P
AU  - Humphrey,E
AU  - Majid,Q
AU  - Grigsby,C
AU  - Stevens,MM
AU  - Terracciano,C
AU  - Harding,SE
AU  - Roy,I
PY  - 2019///
SN  - 1526-7547
TI  - Polyhydroxyalkanoates, ideal materials for cardiac regeneration
ER  -
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