Imperial College London
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ProfessorSianHarding

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Cardiac Pharmacology
 
 
 
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Contact

 

+44 (0)20 7594 3009sian.harding Website

 
 
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Location

 

435ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chow:2017:10.1016/j.stemcr.2017.09.003,
author = {Chow, A and Stuckey, DJ and Kidher, E and Rocco, M and Jabbour, RJ and Mansfield, CA and Darzi, A and Harding, SE and Stevens, MM and Athanasiou, T},
doi = {10.1016/j.stemcr.2017.09.003},
journal = {Stem Cell Reports},
pages = {1415--1422},
title = {Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Encapsulating Bioactive Hydrogels Improve Rat Heart Function Post Myocardial Infarction.},
url = {http://dx.doi.org/10.1016/j.stemcr.2017.09.003},
volume = {9},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Tissue engineering offers an exciting possibility for cardiac repair post myocardial infarction. We assessed the effects of combined polyethylene glycol hydrogel (PEG), human induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM), and erythropoietin (EPO) therapy in a rat model of myocardial infarction. PEG with/out iPSC-CMs and EPO; iPSC-CMs in saline; or saline alone was injected into infarcted hearts shortly after infarction. Injection of almost any combination of the therapeutics limited acute elevations in chamber volumes. After 10 weeks, attenuation of ventricular remodeling was identified in all groups that received PEG injections, while ejection fractions were significantly increased in the gel-EPO, cell, and gel-cell-EPO groups. In all treatment groups, infarct thickness was increased and regions of muscle were identified within the scar. However, no grafted cells were detected. Hence, iPSC-CM-encapsulating bioactive hydrogel therapy can improve cardiac function post myocardial infarction and increase infarct thickness and muscle content despite a lack of sustained donor-cell engraftment.
AU  - Chow,A
AU  - Stuckey,DJ
AU  - Kidher,E
AU  - Rocco,M
AU  - Jabbour,RJ
AU  - Mansfield,CA
AU  - Darzi,A
AU  - Harding,SE
AU  - Stevens,MM
AU  - Athanasiou,T
DO  - 10.1016/j.stemcr.2017.09.003
EP  - 1422
PY  - 2017///
SN  - 2213-6711
SP  - 1415
TI  - Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Encapsulating Bioactive Hydrogels Improve Rat Heart Function Post Myocardial Infarction.
T2  - Stem Cell Reports
UR  - http://dx.doi.org/10.1016/j.stemcr.2017.09.003
UR  - http://hdl.handle.net/10044/1/51767
VL  - 9
ER  -
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