Imperial College London
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ProfessorSianHarding

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Cardiac Pharmacology
 
 
 
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Contact

 

+44 (0)20 7594 3009sian.harding Website

 
 
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Location

 

435ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Machuki:2018:10.1111/apha.12978,
author = {Machuki, JO and Zhang, HY and Harding, SE and Sun, H},
doi = {10.1111/apha.12978},
journal = {ACTA PHYSIOLOGICA},
title = {Molecular pathways of oestrogen receptors and -adrenergic receptors in cardiac cells: Recognition of their similarities, interactions and therapeutic value},
url = {http://dx.doi.org/10.1111/apha.12978},
volume = {222},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Oestrogen receptors (ERs) and βadrenergic receptors (βARs) play important roles in the cardiovascular system. Moreover, these receptors are expressed in cardiac myocytes and vascular tissues. Numerous experimental observations support the hypothesis that similarities and interactions exist between the signalling pathways of ERs (ERα, ERβ and GPR30) and βARs (β1AR, β2AR and β3AR). The recently discovered oestrogen receptor GPR30 shares structural features with the βARs, and this forms the basis for the interactions and functional overlap. GPR30 possesses protein kinase A (PKA) phosphorylation sites and PDZ binding motifs and interacts with Akinase anchoring protein 5 (AKAP5), all of which enable its interaction with the βAR pathways. The interactions between ERs and βARs occur downstream of the Gproteincoupled receptor, through the Gαs and Gαi proteins. This review presents an uptodate description of ERs and βARs and demonstrates functional synergism and interactions among these receptors in cardiac cells. We explore their signalling cascades and the mechanisms that orchestrate their interactions and propose new perspectives on the signalling patterns for the GPR30 based on its structural resemblance to the βARs. In addition, we explore the relevance of these interactions to cell physiology, drugs (especially βblockers and calcium channel blockers) and cardioprotection. Furthermore, a receptorindependent mechanism for oestrogen and its influence on the expression of βARs and calciumhandling proteins are discussed. Finally, we highlight promising therapeutic avenues that can be derived from the shared pathways, especially the phosphatidylinositol3OH kinase (PI3K/Akt) pathway.
AU  - Machuki,JO
AU  - Zhang,HY
AU  - Harding,SE
AU  - Sun,H
DO  - 10.1111/apha.12978
PY  - 2018///
SN  - 1748-1708
TI  - Molecular pathways of oestrogen receptors and -adrenergic receptors in cardiac cells: Recognition of their similarities, interactions and therapeutic value
T2  - ACTA PHYSIOLOGICA
UR  - http://dx.doi.org/10.1111/apha.12978
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000423367700021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/61638
VL  - 222
ER  -
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