Imperial College London
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DrSilviaOttaviani

Faculty of Medicine, Department of Surgery & Cancer

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2823silvia.ottaviani

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sims:2021:10.1016/j.jaci.2020.08.031,
author = {Sims, JT and Krishnan, V and Chang, C-Y and Eagle, SM and Casalini, G and Rodgers, GH and Bivi, N and Nickoloff, BJ and Konrad, RJ and de, Bono S and Higgs, RE and Benschop, RJ and Ottaviani, S and Cardosa, A and Nirula, A and Corbellino, M and Stebbing, J},
doi = {10.1016/j.jaci.2020.08.031},
journal = {Journal of Allergy and Clinical Immunology},
pages = {107--111},
title = {Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfunction in COVID-19},
url = {http://dx.doi.org/10.1016/j.jaci.2020.08.031},
volume = {147},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundPhysicians treating COVID-19 patients increasingly believe that the hyperinflammatory acute stage of COVID-19 results in a cytokine storm. The circulating biomarkers seen across the spectrum of COVID-19 have not been characterized compared to healthy controls, but such analyses are likely to yield insights into the pursuit of interventions that adequately reduce the burden of these cytokine storms.ObjectiveTo identify and characterize the host inflammatory response to SARS-CoV-2 infection, we assessed levels of proteins related to immune responses and cardiovascular disease, in patients stratified as mild, moderate, and severe, versus matched healthy controls.MethodsBlood samples from adult patients hospitalized with COVID-19 were analyzed using high-throughput and ultrasensitive proteomic platforms and compared with age- and sex-matched healthy controls to provide insights into differential regulation of 185 markers.ResultsResults indicate a dominant hyperinflammatory milieu in the circulation and vascular endothelial damage markers within COVID-19 patients, and strong biomarker association with patient response as measured by Ordinal scale. As patients progress, we observe statistically significant dysregulation of IFNγ, IL-1RA, IL-6, IL-10, IL-19, MCP-1, -2, -3, CXCL9, CXCL10, CXCL5, ENRAGE and PARP-1. Furthermore, in a limited series of patients who were sampled frequently confirming reliability and reproducibility of our assays, we demonstrate that intervention with baricitinib attenuates these circulating biomarkers associated with the cytokine storm.ConclusionThese wide-ranging circulating biomarkers show an association with increased disease severity and may help stratify patients and selection of therapeutic options. They also provide insights into mechanisms of SARS-CoV-2 pathogenesis and the host response.
AU  - Sims,JT
AU  - Krishnan,V
AU  - Chang,C-Y
AU  - Eagle,SM
AU  - Casalini,G
AU  - Rodgers,GH
AU  - Bivi,N
AU  - Nickoloff,BJ
AU  - Konrad,RJ
AU  - de,Bono S
AU  - Higgs,RE
AU  - Benschop,RJ
AU  - Ottaviani,S
AU  - Cardosa,A
AU  - Nirula,A
AU  - Corbellino,M
AU  - Stebbing,J
DO  - 10.1016/j.jaci.2020.08.031
EP  - 111
PY  - 2021///
SN  - 0091-6749
SP  - 107
TI  - Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfunction in COVID-19
T2  - Journal of Allergy and Clinical Immunology
UR  - http://dx.doi.org/10.1016/j.jaci.2020.08.031
UR  - https://www.sciencedirect.com/science/article/pii/S0091674920312422?via%3Dihub
UR  - http://hdl.handle.net/10044/1/82435
VL  - 147
ER  -
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