Imperial College London
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DrSilviaOttaviani

Faculty of Medicine, Department of Surgery & Cancer

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2823silvia.ottaviani

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lin:2015:10.18632/oncotarget.3942,
author = {Lin, M-L and Patel, H and Remenyi, J and Banerji, CRS and Lai, C-F and Periyasamy, M and Lombardo, Y and Busonero, C and Ottaviani, S and Passey, A and Quinlan, PR and Purdie, CA and Jordan, LB and Thompson, AM and Finn, RS and Rueda, OM and Caldas, C and Gil, J and Coombes, RC and Fuller-Pace, FV and Teschendorff, AE and Buluwela, L and Ali, S},
doi = {10.18632/oncotarget.3942},
journal = {Oncotarget},
pages = {21685--21703},
title = {Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer},
url = {http://dx.doi.org/10.18632/oncotarget.3942},
volume = {6},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - he Nuclear Receptor (NR) superfamily of transcription factors comprises 48 members, several of which have been implicated in breast cancer. Most important is estrogen receptor-α (ERα), which is a key therapeutic target. ERα action is facilitated by co-operativity with other NR and there is evidence that ERα function may be recapitulated by other NRs in ERα-negative breast cancer. In order to examine the inter-relationships between nuclear receptors, and to obtain evidence for previously unsuspected roles for any NRs, we undertook quantitative RT-PCR and bioinformatics analysis to examine their expression in breast cancer. While most NRs were expressed, bioinformatic analyses differentiated tumours into distinct prognostic groups that were validated by analyzing public microarray data sets. Although ERα and progesterone receptor were dominant in distinguishing prognostic groups, other NR strengthened these groups. Clustering analysis identified several family members with potential importance in breast cancer. Specifically, RORγ is identified as being co-expressed with ERα, whilst several NRs are preferentially expressed in ERα-negative disease, with TLX expression being prognostic in this subtype. Functional studies demonstrated the importance of TLX in regulating growth and invasion in ERα-negative breast cancer cells.
AU  - Lin,M-L
AU  - Patel,H
AU  - Remenyi,J
AU  - Banerji,CRS
AU  - Lai,C-F
AU  - Periyasamy,M
AU  - Lombardo,Y
AU  - Busonero,C
AU  - Ottaviani,S
AU  - Passey,A
AU  - Quinlan,PR
AU  - Purdie,CA
AU  - Jordan,LB
AU  - Thompson,AM
AU  - Finn,RS
AU  - Rueda,OM
AU  - Caldas,C
AU  - Gil,J
AU  - Coombes,RC
AU  - Fuller-Pace,FV
AU  - Teschendorff,AE
AU  - Buluwela,L
AU  - Ali,S
DO  - 10.18632/oncotarget.3942
EP  - 21703
PY  - 2015///
SN  - 1949-2553
SP  - 21685
TI  - Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer
T2  - Oncotarget
UR  - http://dx.doi.org/10.18632/oncotarget.3942
UR  - http://hdl.handle.net/10044/1/27292
VL  - 6
ER  -
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