Imperial College London
Dr Silvia Santos

DrSilviaSantos

Faculty of Medicine, Institute of Clinical Sciences

Honorary Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 8228silvia.santos Website

 
 
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Assistant

 

Miss Kayi Lydia Lawson +44 (0)20 3313 8265

 
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Location

 

2004CRB (Clinical Research Building)Hammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Santos:2012:10.1074/jbc.M111.322909,
author = {Santos, SD and Iuliano, O and Ribeiro, L and Veran, J and Ferreira, JS and Rio, P and Mulle, C and Duarte, CB and Carvalho, AL},
doi = {10.1074/jbc.M111.322909},
journal = {J Biol Chem},
pages = {6868--6877},
title = {Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors.},
url = {http://dx.doi.org/10.1074/jbc.M111.322909},
volume = {287},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Glutamate receptors of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) type mediate fast excitatory synaptic transmission in the CNS. Synaptic strength is modulated by AMPA receptor binding partners, which regulate receptor synaptic targeting and functional properties. We identify Contactin-associated protein 1 (Caspr1) as an AMPA receptor interactor. Caspr1 is present in synapses and interacts with AMPA receptors in brain synaptic fractions. Coexpression of Caspr1 with GluA1 increases the amplitude of glutamate-evoked currents. Caspr1 overexpression in hippocampal neurons increases the number and size of synaptic GluA1 clusters, whereas knockdown of Caspr1 decreases the intensity of synaptic GluA1 clusters. Hence, Caspr1 is a regulator of the trafficking of AMPA receptors to synapses.
AU  - Santos,SD
AU  - Iuliano,O
AU  - Ribeiro,L
AU  - Veran,J
AU  - Ferreira,JS
AU  - Rio,P
AU  - Mulle,C
AU  - Duarte,CB
AU  - Carvalho,AL
DO  - 10.1074/jbc.M111.322909
EP  - 6877
PY  - 2012///
SP  - 6868
TI  - Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors.
T2  - J Biol Chem
UR  - http://dx.doi.org/10.1074/jbc.M111.322909
UR  - https://www.ncbi.nlm.nih.gov/pubmed/22223644
VL  - 287
ER  -
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