Imperial College London
Dr Silvia Santos

DrSilviaSantos

Faculty of Medicine, Institute of Clinical Sciences

Honorary Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 8228silvia.santos Website

 
 
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Assistant

 

Miss Kayi Lydia Lawson +44 (0)20 3313 8265

 
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Location

 

2004CRB (Clinical Research Building)Hammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Araujo:2016:10.1016/j.molcel.2016.09.018,
author = {Araujo, AR and Gelens, L and Sheriff, RSM and Santos, S},
doi = {10.1016/j.molcel.2016.09.018},
journal = {Molecular Cell},
pages = {362--375},
title = {Positive Feedback Keeps Duration of Mitosis Temporally Insulated from Upstream Cell-Cycle Events},
url = {http://dx.doi.org/10.1016/j.molcel.2016.09.018},
volume = {64},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cell division is characterized by a sequence of events by which a cell gives rise to two daughter cells. Quantitative measurements of cell-cycle dynamics in single cells showed that despite variability in G1-, S-, and G2 phases, duration of mitosis is short and remarkably constant. Surprisingly, there is no correlation between cell-cycle length and mitotic duration, suggesting that mitosis is temporally insulated from variability in earlier cell-cycle phases. By combining live cell imaging and computational modeling, we showed that positive feedback is the molecular mechanism underlying the temporal insulation of mitosis. Perturbing positive feedback gave rise to a sluggish, variable entry and progression through mitosis and uncoupled duration of mitosis from variability in cell cycle length. We show that positive feedback is important to keep mitosis short, constant, and temporally insulated and anticipate it might be a commonly used regulatory strategy to create modularity in other biological systems.
AU  - Araujo,AR
AU  - Gelens,L
AU  - Sheriff,RSM
AU  - Santos,S
DO  - 10.1016/j.molcel.2016.09.018
EP  - 375
PY  - 2016///
SN  - 1097-4164
SP  - 362
TI  - Positive Feedback Keeps Duration of Mitosis Temporally Insulated from Upstream Cell-Cycle Events
T2  - Molecular Cell
UR  - http://dx.doi.org/10.1016/j.molcel.2016.09.018
UR  - http://hdl.handle.net/10044/1/40347
VL  - 64
ER  -
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