Imperial College London
Dr Silvia Santos

DrSilviaSantos

Faculty of Medicine, Institute of Clinical Sciences

Honorary Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 8228silvia.santos Website

 
 
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Assistant

 

Miss Kayi Lydia Lawson +44 (0)20 3313 8265

 
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Location

 

2004CRB (Clinical Research Building)Hammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ochoa:2016:10.15252/msb.20167295,
author = {Ochoa, D and Mindaugas, J and Lawrence, RT and El, Debs B and Selkrig, J and Typas, A and Villen, J and Santos, S and Beltrao, P},
doi = {10.15252/msb.20167295},
journal = {Molecular Systems Biology},
title = {An Atlas of human kinase regulation},
url = {http://dx.doi.org/10.15252/msb.20167295},
volume = {12},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The coordinated regulation of protein kinases is a rapid mechanism that integrates diverse cuesand swiftly determines appropriate cellular responses. However, our understanding of cellulardecision-making has been limited by the small number of simultaneously monitored phospho-regulatory events. Here, we have estimated changes in activity in 215 human kinases in 399 condi-tions from a compilation of nearly 3 million phosphopeptide quantifications. This atlas identifiescommonly regulated kinases as those that are central in the signaling network and defines the logicrelationships between kinase pairs. Co-regulation along the conditions predicts kinase-complexand kinase-substrate associations. Additionally, the kinase regulation profile acts as a molecularfingerprint to identify related and opposing signaling states. Using this atlas, we identified essen-tial mediators of stem cell differentiation, modulators of Salmonella infection and new targets ofAKT1. This provides a global view of human phosphorylation-based signaling and the necessarycontext to better understand kinase driven decision-making.
AU  - Ochoa,D
AU  - Mindaugas,J
AU  - Lawrence,RT
AU  - El,Debs B
AU  - Selkrig,J
AU  - Typas,A
AU  - Villen,J
AU  - Santos,S
AU  - Beltrao,P
DO  - 10.15252/msb.20167295
PY  - 2016///
SN  - 1744-4292
TI  - An Atlas of human kinase regulation
T2  - Molecular Systems Biology
UR  - http://dx.doi.org/10.15252/msb.20167295
UR  - http://hdl.handle.net/10044/1/42872
VL  - 12
ER  -
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